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Colorectal cancer is the third most common cancer in the Western hemisphere and the incidence increases with increasing age. Most colorectal cancers are localized with or without lymph node metastases. Up to 20% of patients present with metastatic disease, most commonly to the liver. Surgery is the only curative therapy for localized colorectal cancer and adjuvant chemotherapy is usually recommend
The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and A
Recension av Bengt Liljegren, Winston Churchill. Del 1. 1874–1939.
A parsimonious set of mechanisms explains how and under which conditions behavioral deviations build into cascades that reshape institutional frameworks from the bottom up, even if institutional innovations initially conflict with the legally codified rules of the game. Specifically, we argue that this type of endogenous institutional change emerges from an interplay between three factors: the uti
Popular Abstract in Swedish Bakgrund Hälsopromotion i skolan förespråkas för att främja välmående och förebygga depressiva symtom hos ungdomar, men insatsernas effektivitet och kostnadseffektivitet behöver utvärderas löpande. Depressiva symtom klassas av WHO som den största sjukdomsbördan hos unga människor och skapar såväl stort lidande för den enskilda och de anhöriga, som höga samhällskostnaderBackground: DISA (Depressive Symptoms In Swedish Adolescents) is a cognitive behavioral intervention aimed at preventing stress and depressive symptoms in adolescents. It is frequently used in Swedish schools for students aged 13-15 years. DISA is commonly offered to females, but at some schools, the intervention is also offered to males. In this study, the application of the intervention for both
Religion Crossing Boundaries: Transnational Religious and Social Dynamics in Africa and the New African Diaspora. Edited by Afe Adogame and James V. Spickard. Religion and the Social Order Series, 18. Boston, Massachusetts, USA, Brill 2010. Pp. 280. $53.50. African Christian Presence in the West: New Immigrant Congregations and Transnational Networks in North America and Europe. Edited by Frieder
In this article I discuss how material things can function as a key to a wider understanding of the mission enterprise. From the example of the Swedish missionary Alma Johansson, who worked among Armenian refugees in Thessaloniki, 1923–1947, I analyze the role of needlework in the humanitarian work and show how exchanges of needlework over the borders created cosmopolitan bonds of solidarity betwe
The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the (RB)-B-3 facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5-6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energ
Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.
In high-latitude continental shelf environments, late Pleistocene glacial overdeepening and early Holocene eustatic sea-level rise combined to create restricted marine basins with a high vulnerability to oxygen depletion. Here we show that ongoing glacio-isostatic rebound during the Holocene may have played an important role in determining the distribution of past hypoxia in these environments by
In the year 1900, Sweden probably had the oldest population in the contemporary world. It was also the first nation to implement a universal pension system in 1913. The universal character in early social legislation has certainly been decisive for the development of the Swedish welfare state. This alternative has not been self-evident. Why did the reforms turn universal, when the continental mode
Purpose: Recently, there has been an increasing interest in operating conventional linear accelerators without a flattening filter. The aim of this study was to determine beam quality variations as a function of off-axis ray angle for unflattened beams. In addition, a comparison was made with the off-axis energy variation in flattened beams. Methods: Two Elekta Precise linear accelerators were mod
Popular Abstract in Swedish Att det ska råda fri rörlighet för arbetstagare/personer och deras familjemedlemmar är en grundläggande princip i EU-rätten. I artikel 48 i Fördraget om Europeiska unionens funktionssätt (EUF) ges EU befogenhet att vidta åtgärder för att koordinera, samordna, de olika nationella sociala trygghetssystemen inom EU. Förordning 1408/71 och dess ersättare förordning 883/2004This doctoral thesis examines the Swedish parental benefit in relation to the EU principles on free movement, namely the Treaty provisions on free movement for workers and Union citizens, and more specifically, the legislation on coordination of social security benefits – Regulation 1408/71 and its successor Regulation 883/2004. The rights enshrined in the Treaty on the Functioning of the European
The number of nanoparticle-based products on the market is expected to increase considerably during the coming decades. This forces the industry to have highly meticulous manufacturing of large amounts of nanoparticles using cheap and environmentally friendly methods. For the production of metal nanoparticles spark discharge generation is a promising route to fulfill these demands. The spark disch
