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Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308

Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on A

Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes

OBJECTIVE - Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS - We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyoce

Isolation and characterization of a stress responsive small GTP-binding protein AhRabG3b in peanut (Arachis hypogaea L.)

Rab7 is a member of small GTP-binding protein family involved in intracellular vesicle trafficking from late endosome to vacuole, some of them are found to be responsive by different environmental stresses. Here we report the isolation of a Rab7 (RabG3b) cDNA from peanut (Arachis hypogaea). Overexpression of the open reading frame (ORF) of Rab7 cDNA encoding 205 amino acids in E. coli conferred th

Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study

Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and sel

Lieb-Thirring inequalities on the half-line with critical exponent

We consider the operator -d(2)/dr(2) - V in L-2(R+) with Dirichlet boundary condition at the origin. For the moments of its negative eigenvalues we prove the bound [GRAPHICS] for any alpha is an element of [0, 1) and gamma >= (1 - alpha)/2. This includes a Lieb-Thirring inequality in the critical endpoint case.

From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster

Embryonic development is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. In many instances, conserved Rho-family GTPases that are activated by Rho guanine nucleotide exchange factors (RhoGEFs) play an important role in this process. The present thesis investigates

Evolutionary responses to environmental changes: How does competition affect adaptation?

The role and importance of ecological interactions for evolutionary responses to environmental changes is to large extent unknown. Here it is shown that interspecific competition may slow down rates of adaptation substantially and fundamentally change patterns of adaptation to long-term environmental changes. In the model investigated here, species compete for resources distributed along an ecolog

Governing Decarbonisation : The State and the New Politics of Climate Change

Popular Abstract in English The new climate politics of decarbonisation address the prospects for moving society away from its current dependence on fossil carbon energy. In this compilation dissertation, Hildingsson explores the role of the state as a critical site for progressive climate action, and examines its capacity to govern decarbonisation by transforming systems, structures and practicesThis dissertation examines the “new climate politics of decarbonisation” and the role of the state as a site for progressive climate action. This new politics concerns transformative social change aimed at moving society away from its current dependence on fossil carbon energy. A transition to low-carbon societal development hinges on restructuring and decarbonising those key systems, structures a

Combinatorial nuclear level-density model

A microscopic nuclear level-density model is presented. The model is a completely combinatorial (micro-canonical) model based on the folded-Yukawa single-particle potential and includes explicit treatment of pairing, rotational and vibrational states. The microscopic character of all states enables extraction of level-distribution functions with respect to pairing gaps, parity and angular momentum

The role of transnational dimensions in emerging economy 'Technological Innovation Systems' for clean-tech

The 'Technological Innovation System' (TIS) framework and its system functions have become a popular analytical tool for the study of clean-tech innovation. There is increasing attention for the role of emerging economies in global clean-tech innovation, but the applicability of TIS to emerging economies cases is not entirely straightforward. A key issue is the limited geographical considerations,

Interaction of Hurricanes and Natural Coastal Features: Implications for Storm Damage Reduction

It is generally acknowledged that wetlands and barrier islands can reduce surge and waves. However, while a general qualitative understanding of these interactions is available in the scientific literature, quantification of these interactions is lacking and has previously been based on limited data of relatively poor quality. The overall aim of this study was to improve the understanding of the i

Studies of 1H-NMR Relaxation Dispersion in Human Brain- tissue Samples: Implications for Magnetic Resonance Relaxation Dispersion Imaging (MARDI)

Studies of 1H-NMR Relaxation Dispersion in Human Brain- tissue Samples: Implications for Magnetic Resonance Relaxation Dispersion Imaging (MARDI) Bertil R.R. Persson1, Lars Malmgren1,2 and Leif G. Salford3 1Medical Radiation Physics 2MAX Laboratory 3Dept. of Neurosurgery, Lund University, Lund Sweden [Bertil R.R. Persson, Lund University, Dept. of medical radiation physics, Barngatan 2, S-22185 Lu

HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later

Aims/Hypothesis: HLA genes, islet autoantibodies and residual C-peptide were studied to determine the independent association of each exposure with diabetic retinopathy (DR), 15 years after the clinical onset of type 1 diabetes in 15-34 year old individuals. Methods: The cohort was identified in 1992 and 1993 by the Diabetes Incidence Study in Sweden (DISS), which investigates incident cases of di

Gender affects skin wound healing in plasminogen deficient mice.

The fibrinolytic activity of plasmin plays a fundamental role in resolution of blood clots and clearance of extravascular deposited fibrin in damaged tissues. These vital functions of plasmin are exploited by malignant cells to accelerate tumor growth and facilitate metastases. Mice lacking functional plasmin thus display decreased tumor growth in a variety of cancer models. Interestingly, this ro

Oxygen-Stabilized Rh Adatoms: 0D Oxides on a Vicinal Surface

We have investigated the initial oxidation of the Rh(113) and Rh(223) vicinal surfaces by STM and ab initio simulations. Upon adsorption of small amounts of oxygen, the surface morphology is completely altered. Surprisingly, oxygen-stabilized Rh adatoms can be observed on the (113) facets, with oxide-like electronic properties. We present models of these "0D oxide" phases and discuss reasons for t

Using service simulation to analyse the satisfaction with the processes of intensive care unit in the hospital: the perspective of the patient and the family

In the hospital, intensive care unit (ICU) is an isolated space where patients with acute symptoms are treated. When the patients are in ICU, their families are usually in psychological crisis and under great pressure. The value of ICU is thus to provide a complete ICU service by which not only the patients receive good treatment, but the feelings of family members are also considered and managed.

Effects of 17α-ethinylestradiol on individual life-history parameters and estimated population growth rates of the freshwater gastropods Radix balthica and Bithynia tentaculata.

Studies of aquatic environments exposed to 17α-ethinylestradiol (EE2) have demonstrated detrimental effects on fish communities. However, much less is known about effects on macro-invertebrates and especially how long-term exposure may affect critical life stages and ultimately population dynamics. We studied the effects of EE2 on relevant endpoints for population growth in two common freshwater g