Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignanci

Multiparameter flow cytometry (MFC) is one of the essential ancillary methods in bone marrow (BM) investigation of patients with cytopenia and suspected myelodysplastic syndrome (MDS). MFC can also be applied in the follow-up of MDS patients undergoing treatment. This document summarizes recommendations from the International/European Leukemia Net Working Group for Flow Cytometry in Myelodysplasti

Sex differences in lifespan are ubiquitous across the tree of life and exhibit broad taxonomic patterns that remain a puzzle, such as males living longer than females in birds and vice versa in mammals. The prevailing unguarded X hypothesis explains sex differences in lifespan by differential expression of recessive mutations on the X or Z chromosome of the heterogametic sex, but has only received

This work explores the use of reinforcement learning to design a proactive cloud resource auto-scaler that is able to predict usage across a distributed microservice application. The focus is on serving time-sensitive workloads, e.g., industrial automation, connected XR/VR (eXtended Reality/Virtual Reality), etc., where each job has a deadline and there is some cost associated with missing a deadl

Deep in the mountains near the Allegheny National Forest in Pennsylvania, USA lay the twisted ruins of the Kinzua Bridge, once an important transportation link and landmark for the region’s identity and heritage. Once the bridge fell out of use in the late 1950s, the Kinzua Bridge State Park was created to promote tourism and highlight the region’s history and exceptional natural landscapes. Yet,

Nyckeln bakom en lyckad (torrpulver-) formulering För att möjliggöra en lyckad administrering av inhalationsläkemedel är det många faktorer som spelar in. Däribland hur tillverkningen av formuleringen går till. Till skillnad från vad många kanske tror, har inhalation länge använts som ett sätt att administrera läkemedel till lungan. Så länge, att de äldsta fynden daterar tillbaka ända till gamlaFor efficient treatment of many diseases of the lung, it is beneficial to deliver the medicine to the respiratory tract directly. This ensures a rapid response since it can enter the bloodstream directly through the alveolar epithelium. Consequently, also decreases systemic effects due to the local treatment. Dry powder inhaler (DPI) is today one of the most used inhalers for pulmonary delivery.

Vertical graphene (VG) is a remarkable electrode material for supercapacitors due to its large specific area, open channel structures, and numerous exposed edges with high electrochemical activity. However, flexible supercapacitors with high rate performance based on VG have yet to be investigated. Here, we report flexible supercapacitors based on VG, carbon fabric (CF) current collector, and H2SO

Mitt avhandlingsarbete är ett teoretiskt utforskande av den mellanmänskliga förståelsens tvetydiga roll i praktiskt socialt arbete. Avhandlingen är en sammanläggningsavhandling vilket betyder att den är uppbyggd av flera delstudier och en introducerande tillika sammanfattande kappa. I mina fyra delstudier om ämnena empati, stigmatisering och kamratstöd undersöker jag olika aspekter av mellanmänsklThis thesis aims to explore how phenomenological philosophy may contribute to the conception of interpersonal understanding in the context of social work practice. The thesis consists of an extended introduction and four original papers, investigating modalities of interpersonal understanding in relation to three different subjects, namely empathy, stigmatization, and peer-support. The thesis sets

Background: Patient representatives are increasingly engaged in quality in health care, and even though quality data are publicly available, correct interpretation may be challenging. We designed a randomized study with the primary aim to examine the association between preferred data presentation format and the interpretation of quality data among cancer patients and relatives. Material and metho

Entreprenadavtal är förknippat med ett antal särdrag och betraktas vanligen som en avtalstyp. Det finns ingen direkt tillämplig lagstiftning som reglerar parternas rättigheter och skyldigheter i kommersiella entreprenadavtal. Denna avtalstyp regleras istället i stor omfattning av entreprenadbranschens standardavtal. Det förhärskande standardavtalet på området är AB 04. Utmärkande för entreprenadavConstruction contracts are associated with a number of special features. There is a general lack of directly applicable legal rules addressing the parties’ obligations in construction contracts. Instead, standard forms are predominantly used for commercial ventures in the construction industry. The most dominant standard form in Sweden is AB 04. Construction contracts is characterized by its gener

This paper presents a scoping review of methods for fire evacuation training in buildings. It adopts the PRISMA methodology (Transparent Reporting of systematic Reviews and Meta-Analyses) and systematically identifies 73 sources among scientific literature published between 1997 and 2022. It was found that the literature is dominated by research on modern technology (Augmented Reality, Virtual Rea

T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. This model has become almost a

Purpose: Fatigue is a major symptom of ABI. Greater fatigue is associated with cognitive impairment. Our aim was to systematically review, describe and analyse the literature on the extent of this relationship. Methods: Five databases were searched from inception. Studies were included where: participants had a defined clinical diagnosis of ABI which included TBI, stroke or subarachnoid haemorrhag

The current concept of social resilience, which developed from the classic definition of resilience, neglects social resilience as a social phenomenon including social experiences and practices in the face of change and adversity. I argue that framing social resilience as a capacity or ability undermines its characteristics as a complex and contextualized social phenomenon that contributes to adap

Climate change stressors, including warming and heatwaves, can alter plankton composition and dominance patterns in temperate shallow lakes, which can disrupt ecosystem function and curtail ecosystem services. Understanding how these alterations could take place under future climates is therefore important. To understand such changes, we performed a year-long mesocosm experiment with controls refl

Social work education has been subject to discussion throughout history. The competence of newly graduated social workers is questioned in facing complex social problems and new challenges in society. The purpose of this study has been to shed light on how newly graduated social workers’ theoretical knowledge and practical skills are perceived by managers in the exercise of authority who work clos

This study aimed to explore which understanding social work professionals have of sugar dating among youth under the age of 18. Furthermore, the purpose of the study was to discover which children engage in sugar dating from the perspective of professionals. We conducted six semi-structured interviews with different social work professionals. The findings from our interviews were analyzed through

Uppsatsen har som syfte att kritiskt granska försvarlighetsbedömningen och excessbedömningen som görs i nödvärnssituationer. Ett psykologiskt perspektiv används för att analysera huruvida Högsta domstolen har skapat en för långtgående skyldighet att fly istället för att försvara sig med våld. Det är endast nödvärn vid brottsligt angrepp på person som behandlas. Jag använder mig av den rättsdogmatiThe purpose of this essay is to critically examine the Supreme Court’s judgments regarding the justifiability of self-defense and excessive self-defense. A psychological perspective is applied to analyze if the Supreme Court has created a too extensive obligation to escape instead of using violence to defend oneself. This essay only covers self-defense from criminal attacks on a person. I use a le

Acoustic streaming at high acoustic energy densities Eac is studied in a microfluidic channel. It is demonstrated theoretically, numerically, and experimentally with good agreement that frictional heating can alter the streaming pattern qualitatively at high Eac above 400 J/m^3. The study shows how as a function of increasing Eac at fixed frequency, the traditional boundary-driven four streaming r

Women human rights defenders are the center of the thesis (WHRDs). The thesis is based on my three years of professional experience as a human rights defender, which have given me a thorough awareness of the challenges WHRDs encounters and the knowledge I obtained through the postgraduate course. Considering that I was unfamiliar with the exact challenges WHRDs faced, I wanted to examine problems