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The Intimate Lives of Disabled People
Procedural pain in lumbar punctures and the impact of preparation in pediatric cancer patients
Aim: Childhood cancer patients are subjected to recurring painful medical procedures. In low- and middle-income countries (LMIC), where the majority of the world's childhood cancer patients live, pain management is often unsatisfactory due to limited resources. This study aimed to evaluate the possibility of conducting a preprocedural preparation for lumbar punctures (LPs) at a pediatric oncology
Fuktegenskaper hos cementbundet material med flygaskainblandning
Med cementbundna materials fuktegenskaper menas hur de binder och transporterar vatten. Känner man fuktegenskaper kan man räkna ut hur exempelvis en betong torkar. Mätning av fuktegenskaper för cementbundna material är något Avd. Byggnadsmaterial i Lund har stor erfarenhet av, särskilt för material med Portlandcement som bindemedel [1] [2]. På senare år har forskning vid avdelningen också visat hu
Hypoxia and Stem Cells in Normal and Tumor Development
Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models.In the first part of this thesis, we established two preclinical in
When did the Health Gradient Emerge? : Social Class and Adult Mortality in Southern Sweden, 1813-2015
Across today’s developed world, there is a clear mortality gradient by socioeconomic status at all ages. It is often taken for granted that this gradient was as strong, or even stronger, in the past, when social transfers were rudimentary and health-care systems less developed. While some studies based on cross-sectional data support this view, others based on longitudinal data find that this was Across today’s developed world, there is a clear mortality gradient by socioeconomic status for all ages. It is often taken for granted that this gradient was as strong—or even stronger—in the past when social transfers were rudimentary and health care systems were less developed. Some studies based on cross-sectional data have supported this view, but others based on longitudinal data found that
Normative Foundations of Nordic Family and Gender Equality Policies: Developments and Challenges
Review of Gary Alan Fine, Talking Art: The Culture of Practice and the Practice of Culture in MFA Education.
Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma
Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. The underlying mechanisms involved in ATC tumorigenesis is under
Vilka röster hörs? Funktionshinderrörelsens karaktär och intressepolitiska arbete
Sustainable Development: A Typology of Perspectives
HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy
The incidence of narcolepsy type 1 (NT1) increased in Sweden following the 2009-2010 mass-vaccination with the influenza Pandemrix-vaccine. NT1 has been associated with Human leukocyte antigen (HLA) DQB1*06:02 but full high-resolution HLA-typing of all loci in vaccine-induced NT1 remains to be done. Therefore, here we performed HLA typing by sequencing HLA-DRB3, DRB4, DRB5, DRB1, DQA1, DQB1, DPA1
Tensor-valued diffusion MRI in under 3 minutes : an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors
Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluate
A droplet-based microfluidics route to temperature-responsive colloidal molecules
Small clusters of spherical colloids that mimic real molecules, so-called colloidal molecules, hold great promise as building blocks in bottom-up routes to new materials. However, their typical hard sphere nature has hampered their assembly into ordered structures, largely due to a lack of control in the interparticle interactions. To provide easy external control of the interactions, the present
Using intensive longitudinal data to study treatment effects in patients with major depression : A systematic review
Depression is a disabling condition, causing suffering worldwide. The purpose of this paper is to review studies that have used Intensive Longitudinal Data (ILD) in research on depression treatment. Intensive longitudinal data in the form of daily diaries, experience sampling method (ESM), and ecological momentary assessment (EMA) are increasingly used in psychotherapy research to gather individua
Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study
Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A to
A survey of the physiotherapy treatment methods for infants hospitalised with acute airway infections in Sweden
Purpose: The purpose of this study was to investigate what treatment methods physiotherapists in Sweden use for infants 0–24 months hospitalised with acute breathing difficulties due to lower respiratory tract infections. Material and methods: We constructed an anonymous digital survey for paediatric physiotherapists in Sweden. It was distributed by e-mail and was posted on professional websites.
Calcein release assay as a method for monitoring serum complement activity during monoclonal antibody therapy in patients with B-cell malignancies
Monoclonal antibodies ofatumumab (anti-CD20) and alemtuzumab (anti-CD52) which are approved for usage in patients with chronic lymphocytic leukemia (CLL), efficiently activate the classical complement pathway. However complement is an exhaustible component and high doses of its activators may deplete complement-dependent cytotoxicity (CDC) potential, thus reducing the effect of repeated mAb dosing
Ultrafast dynamics in QD based photoelectrochemical cells
We have prepared electrodes for photo-electro-chemical cells which have enabled to pre-charge colloidal quantum dots in well-controlled fashion. Femtosecond transient absorption measurements were carried out revealing clear speed-up of the photo-induced charge carrier dynamics, particularly the recombination. Such studies allow to understand the behavior of light harvesting materials in operationa
Twelve per cent of 6142 eyes treated for neovascular age-related macular degeneration (nAMD) presented with low visual outcome within 2 years. Analysis from the Swedish Macula Registry (SMR)
Purpose: To analyse characteristics from the SMR to explore the risk factors for visual acuity (VA) below ≤ 35 letters of the Early Treatment Diabetic Retinopathy Study (ETDRS) due to nAMD during a two-year follow-up. Methods: This study evaluates 6142 treatment-naïve eyes, with focus on a subgroup of 780 eyes with final VA outcome of ≤ 35 letters, regarding differences of baseline characteristics