Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of

We studied the association between neighborhood socioeconomic status (SES) and incidence of coronary heart disease (CHD) or ischemic stroke in the total population and in full- and half-siblings to determine whether these associations are causal or a result from familial confounding. Data were retrieved from nationwide Swedish registers containing individual clinical data linked to neighborhood of

Background Acute coronary syndrome is a common cause of out-of-hospital cardiac arrest (OHCA). In patients with OHCA presenting with ST elevation, immediate coronary angiography and potential percutaneous coronary intervention (PCI) after return of spontaneous circulation are recommended. However, the evidence for this invasive strategy in patients without ST elevation is limited. Observational st

Anticoagulant treatment of acute pulmonary embolism (PE) has traditionally been hospital-based. The lesser need for monitoring with the increasingly used direct acting oral anticoagulants (DOAC) in comparison to warfarin potentially facilitates outpatient treatment of PE with these drugs. This study aimed to evaluate efficacy and safety of outpatient treatment of PE with DOAC. We extracted data fr

The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-b

Basing their study on conceptualizations current in anthropology, history, memory studies, and cultural sociology, Eleonora Narvselius and Gelinada Grinchenko offer a new, complex approach to understanding the violations of loyalty and trust that constitute betrayal, as well as their present-day revisions. Acts of betrayal and their subsequent reinterpretations are viewed through the prism of powe

Bose-Einstein correlations between identified charged pions are measured for p+Pb collisions at sNN=5.02TeV using data recorded by the ATLAS detector at the CERN Large Hadron Collider corresponding to a total integrated luminosity of 28nb-1. Pions are identified using ionization energy loss measured in the pixel detector. Two-particle correlation functions and the extracted source radii are presen

Taking for granted the view that belief-less, ‘non-doxastic’, engagement with religion is possible, this article discusses the proper object of such religiosity. Its focus is the claim of J. L. Schellenberg that non-doxastic religion should be directed at ’simple ultimism’. I argue that ‘simple ultimism’ is too abstract to allow for alignment with religious reality. Traditional religion is a bette

Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo

In this Letter, we study the collective behavior of a large number of self-propelled microswimmers immersed in a fluid. Using unprecedentedly large-scale lattice Boltzmann simulations, we reproduce the transition to bacterial turbulence. We show that, even well below the transition, swimmers move in a correlated fashion that cannot be described by a mean-field approach. We develop a novel kinetic

We present a novel action recognition system that is able to learn how to recognize and classify actions. Our system employs a three-layered hierarchy of Self-Organizing Maps together with a supervised neural network for labelling the actions. We have evaluated our system in an experiments consisting of ten different actions from a publicly available data set. The results are encouraging with 83%

‘Sustainability’, often presented through an ecological–economic–social triad, is today one of spatial planning’s absolute key concepts (and key priorities). But it is also a highly contested concept, whose meaning is often considered evasive or vague. In this paper, we try to counterweigh such evasiveness by putting emphasis on the material landscape produced within a project that is frequently d

Background and purpose This study presents the evaluation of acute and late toxicities of the lung in children and adolescents after irradiation in terms of dose–volume effects. Materials and methods Irradiated children and adolescents in Germany have prospectively been documented since 2001 in the “Registry for the Evaluation of Side-Effects after Radiotherapy in Childhood and Adolescence (RiSK)”

This paper studies the importance of the interdependences within platform-based markets. Specifically, the work examines the influence of complementary product portfolios on the adoption of platforms by individuals. The study analyzes data from a panel of 17 video game platforms in three regions (the US, Japan and Europe) for the period between 1989 and 2011. The results suggest that platform adop