Background: The late-phase reaction (LPR) of the skin is an in vivo model of allergic inflammation. Objective: We sought to identify disease-associated pathways in the LPR using a network-based analysis. Methods: The LPR was examined by means of DNA microarray analysis of skin biopsy specimens from 10 patients with allergic rhinitis and 10 healthy control subjects. The results were further analyze

OBJECTIVE: To monitor the concentration of markers of cartilage and synovium metabolism in the knee (stifle) joint synovial fluid of young beagles subjected to immobilisation and subsequent remobilisation.METHODS: The right hind limb of 17 dogs was immobilised in flexion for 11 weeks. Simultaneously, the contralateral left knee was exposed to increased weight bearing. The remobilisation period las

Leucocyte elastase in catalytic amounts was observed to rapidly cleave the Val-10-Gly-11 bond of the human cysteine-proteinase inhibitor cystatin C at neutral pH. The resulting modified inhibitor had size and amino acid composition consistent with a cystatin C molecule devoid of the N-terminal Ser-1-Val-10 decapeptide. Leucocyte-elastase-modified cystatin C had more than 240-fold lower affinity th

Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies for these diseases. Activation of the calcium dependent protease, calpain, has been suggested to play an important role in cell death in various ne

Blood coagulation factor V (FV) is a 330 kDa plasma glycoprotein. Activated FV (FVa) is a non-enzymatic cofactor to activated Factor X in the activation of prothrombin that occurs during coagulation. To investigate the molecular mechanisms of the quantitative FV deficiency associated with the FV R2 haplotype (a common genetic variant in several populations), four missense mutations identified in

We consider homogeneous density functions for proving almost globalattractivity of the zero equilibrium in a homogeneous system. It is shownthat the existence of such a function is guaranteed whenthe equilibrium is asymptotically stable, or in the more general case, whenthere exists a nonhomogeneous density function for the same systemsatisfying some reasonable conditions. Results related to robus

Epidemiological studies have shown diet to be an important factor in the global variation of human cancer rates. The presence of mutagenic/carcinogenic heterocyclic aromatic amines (HAs) in cooked foods has attracted a great deal of interest for more than 20 years. Accurate assessment of the human exposure to HAs requires food questionnaires that address cooking methods and reliable methods for th

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Recension av Gunnar Wetterberg; Levande 1600-tal. Essäer.

The fragile histidine triad (FHIT) gene, located within chromosome arm 3p, is a potential target for testicular tumorigenesis. In the present study, 62 primary testicular germ cell tumors were analyzed for allelic imbalance (AI) at 10 loci mapping to chromosome bands 3p14.1-21.1. Twenty-seven tumors (44%) showed AI at one or more 3p loci. The chromosome 3 copy number was evaluated by fluorescence

Narrowband and wideband measurements of the radio channel using different combinations of transmit and receive polarization have been performed. The measurements cover a range of scenarios including urban, suburban and open terrain, as well as both outdoor and indoor terminals. The vertical-to-vertical (V-V) and horizontal-to-horizontal (H-H) polarization combinations are found to provide equal re

We derive a partition function for the Lund fragmentation model and compare it with that of a classical gas. For a fixed rapidity “volume” this partition function corresponds to a multiplicity distribution which is very close to a binomial distribution. We compare our results with the multiplicity distributions obtained from the JETSET Monte Carlo for several scenarios. Firstly, for the fragmentat