Abstract in German Die Bestimmung des prostataspezifischen Antigens (PSA) ist in der Frühdiagnostik des Prostatakarzinoms nach wie vor von zentraler Bedeutung. Ein ungelöstes Problem ist jedoch die geringe Spezifität dieses organ- aber nicht karzinomspezifischen Serummarkers, die bei einer hohen Anzahl von Patienten zu weiterer, dann invasiver Diagnostik führt, ohne dass ein Prostatakarzinom gefunDetection of prostate-specific antigen remains the mainstay in the early detection of prostate cancer. A problem yet unsolved is the lack of specificity of this organ- but not cancer-specific marker, which generates subsequent, invasive procedures in a high number of patients without detecting prostate cancer. While the separate detection of free PSA and the ratio of free to total PSA has signific

Interaction forces between charged interfaces in the presence of oppositely charged dendrimers are studied by experiment and simulation. The experiments involve direct force measurements with all atomic force microscope (AFM) between two negatively charged colloidal particles in the presence of adsorbed, positively charged globular dendrimers. The simulations are carried out by treating the macroi

Residual stress and distortion continue to be important issues in shipbuilding and are still subject to large amounts of research. This paper demonstrates how the type of welding process influences the amount of distortion. Many shipyards currently use submerged arc welding (SAW) as their welding process of choice. In this manuscript, the authors compare welds made by SAW with DC gas metal arc wel

The task of a fast correlation attack is to efficiently restore the initial content of a linear feedback shift register in a stream cipher using a detected correlation with the output sequence. We show that by modeling this problem as the problem of learning a binary linear multivariate polynomial, algorithms for polynomial reconstruction with queries can be modified through some general technique

Shallow marine, nearshore strata of earliest Campanian (Gonioteuthis granulataquadrata belemnite Zone) and latest Early Campanian (informal Belemnellocamax mammillatus belemnite zone) age in the Kristianstad Basin, southern Sweden, have yielded isolated leptoceratopsid teeth and vertebrae, representing the first record of horned dinosaurs from Europe. The new leptoceratopsid occurrence may support

Dampness in buildings has been linked to adverse health effects, but the specific causative agents are unknown. Mycotoxins are secondary metabolites produced by molds and toxic to higher vertebrates. In this study, mass spectrometry was used to demonstrate the presence of mycotoxins predominantly produced by Aspergillus spp. and Stachybotrys spp. in buildings with either ongoing dampness or a hist

In this paper, a novel data scaling method for pipelined FFT processors is proposed. By using data scaling, the FFT processor can operate on a wide range of input signals without performance loss. Compared to existing block scaling methods, like implementations of Convergent Block Floating Point (CBFP), the memory requirements can be reduced while preserving the SNR. The FFT processor has been syn

Water-soluble poly(acrylic acid) has been covalently labeled with a fluorescent hydrophobic chromophore, naphthalene (Np), randomly attached onto the polymer backbone with an amount of 3 mol %. The polymer, which is a new type of hydrophobically modified polymer denoted PAAMeNp-34, was investigated using steady-state fluorescence spectroscopy in aqueous solutions of different pH and in methanol. T

Current-voltage curves of molecular single-electron tunneling transistors are simulated based on a modified theory of single electronics that accounts for the discreteness of the energy spectrum of the molecule. The simulation was performed including effects of energy relaxation of the electrons in the molecule for two limiting cases of fast and slow relaxation, and for both equidistant and random

The lifetime broadening and molecular field splitting of the sodium dimer 2p core level is studied by x-ray photoelectron spectroscopy and by Auger electron spectroscopy. The lifetime of the Na 2p core hole has been determined to be 15 +/- 8 fs, much shorter than what has previously been reported for solid sodium. The molecular field splitting of this core level has been determined to be 42 +/- 10

BACKGROUND: The plasma level of endothelin-1 is locally increased during cooling but the net vasoconstrictor effect will be dependent on temperature effects on the vascular smooth muscle reactivity in response to the polypeptide. The aim of this study was to investigate the effect of cooling on the vascular smooth muscle response to endothelin-1 in human and rat veins. METHODS: Registration of vas

Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled

The objective of this simulation study is to investigate whether the likelihood ratio (LR) test can pick the optimal lag order in the vector autoregressive model when the most applied information criteria (i.e. vector Schwarz-Bayesian, SBC and vector Hannan-Quinn, HQC) suggest two different lag orders. This lag-choosing procedure has been suggested by Hatemi-J (1999). The results based on the Mont

A coupled carbon and water flux model (BIOME2) captures the broad-scale environmental controls on the natural distribution of vegetation structural and phenological types in Australia. Model input consists of latitude, soil type, and mean monthly climate (temperature, precipitation, and sunshine hours) data on a 1/10 degrees grid. Model output consists of foliage projective cover (FPC) for the qua

Tanner GA, Rippe C, Shao Y, Evan AP, Williams JC, Jr. Glomerular permeability to macromolecules in the Necturus kidney. Am J Physiol Renal Physiol 296: F1269-F1278, 2009. First published April 1, 2009; doi: 10.1152/ajprenal.00371.2007.-Many aspects of the glomerular filtration of macromolecules remain controversial, including the location of the major filtration barrier, the effects of electrical

In this study the Delphi technique has been used to develop a core curriculum for education of the biomedical scientist. The rapid development in biomedicine and the corresponding changes in methodology in biomedical laboratories demand careful planning of the education of biomedical scientists. The Delphi technique uses an anonymous panel of experts for suggestions and assessments aiming at conse