In this paper, we present a global solution to a nonlinear H-infinity optimal control problem for control-affine systems with an associated potential function. We also give a closed-form expression for an optimal controller and demonstrate its potential for sparsity. This paper thus advances a recent result which considers the same problem restricted to systems with symmetric state matrix and nonl

Background: Patients with non-small cell lung cancer (NSCLC) harboring a ROS proto-oncogene 1 (ROS1)-rearrangement respond to treatment with ROS1 inhibitors. To distinguish these rare cases, screening with immunohistochemistry (IHC) for ROS1 protein expression has been suggested. However, the reliability of such an assay and the comparability of the antibody clones has been debated. Therefore we e

Calculations of two-dimensional unsteady flow around a quadratic two-dimensional cylinder at zero angle of attack are performed. The Reynolds numbers are low (Re = 45 - 250) so that the flow presumably is laminar. At Re > 50 a von Karman vortex street with a well-defined shedding frequency is predicted. An incompressible SIMPLEC finite volume code employing non-staggered grid arrangement is used.

Bakgrund: Enligt Socialstyrelsens rekommendationer bör vårdpersonal aktivt uppmuntra föräldrar till närvaro och vård av sitt för tidigt födda barn för att säkerställa deras delaktighet. Svensk neonatalvård anses ligga i framkant men det finns utrymme för förbättringar av det psykosociala stödet och omhändertagandet av föräldrar. Enligt Svenskt Neonatalt Kvalitetsregisters årsrapport 2021 framkomme

Bryophytes (mosses, liverworts, and hornworts) have interested researchers because of their high chemical diversity and their potential uses in pharmaceutical, food, and cosmetic industries. Specifically, long-chain polyunsaturated fatty acids (l-PUFA) such as arachidonic acid (AA) and eicosapentaenoic acid (EPA) are commonly found in bryophytes, but not in vascular plants. Bryophytes accumulate P

Evidence is lacking on how to understand the reasons for variations, both in prevalence of ADHD and ADHD medication prescribing patterns in children and adolescents, within Region Skåne. These variations are not in line with current national clinical guidelines and seem to have increased over time. This qualitative interview study illuminates pediatric psychiatrists' attitudes toward ADHD and thei

RATIONALE: Idiopathic pulmonary fibrosis is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to non-genetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, and exome studies have also been reported to associate with IPF. However, the extent to which rare variants genome-wide may contribut

Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we used bio-orthogonal non-canonical amino acid tagging for global analysis of newly translated proteins in fibro

Bacteriophages encode a wide variety of cell wall disrupting enzymes that aid the viral escape in the final stages of infection. These lytic enzymes have accumulated notable interest due to their potential as novel antibacterials for infection treatment caused by multiple-drug resistant bacteria. Here, the detailed functional and structural characterization of Thermus parvatiensis prophage pe

While consumer engagement and value cocreation research proliferate, it is important to explore these concepts from an ecosystem-based multi-stakeholder perspective as, therefore, undertaken in this article. Specifically, this study marks a pioneering attempt in conceptualizing stakeholder engagement (SE) as a core foundation of stakeholder value cocreation within multi-stakeholder service ecosyst

A significant fraction of an exoplanet transit model evaluation time is spent calculating projected distances between the planet and its host star. This is a relatively fast operation for a circular orbit, but slower for an eccentric one. However, because the planet's position and its time derivatives are constant for any specific point in orbital phase, the projected distance can be calculated ra

This paper presents a systematic investigation of the influence of streamturbulence on the pressure forces on a single tube. Grids were used to producedifferent turbulent flow fields with longitudinal integral scale (eddy size)ranging from 0.1 to 0.5 tube diameters and turbulence intensities ranging from0.1 to 3-2 %. The measurements were carried out at two Reynolds numbers, 2.7 - 10 and U.1-104 ,

We present a detailed analysis of HARPS-N radial velocity observations of K2-100, a young and active star in the Praesepe cluster, which hosts a transiting planet with a period of 1.7 d. We model the activity-induced radial velocity variations of the host star with a multidimensional Gaussian Process framework and detect a planetary signal of 10.6 ± 3.0 m s−1, which matches the transit ephemeris,

Mosses have often been used for biomonitoring because of their diversity of habitats, structural simplicity, and rapid multiplication rate. This research aimed to study the tolerance of heavy metal in 3 species of terricolous mosses i.e., Barbula consanguinea, Hyophila apiculata, and H. involuta. The gametophores of mosses were immersed at 4 concentrations of each of the heavy metals Cd, Pb, and Z

Background: Drug Use Disorder (DUD) is a major contributor to world-wide morbidity and mortality. The extensive national registers in Sweden provide the basis for a study of spatial and temporal patterns of DUD onset and recurrence in Sweden from 2001–2015. Methods: To identify patterns of DUD over space, time and gender for Swedish individuals aged 15–35, space–time clustering using SaTScan was a