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Eye evolution and its functional basis

Eye evolution is driven by the evolution of visually guided behavior. Accumulation of gradually more demanding behaviors have continuously increased the performance requirements on the photoreceptor organs. Starting with nondirectional photoreception, I argue for an evolutionary sequence continuing with directional photoreception, low-resolution vision, and finally, high-resolution vision. Calcula

Getting Innovation Done

Creating innovations that successfully meet societal challenges on a grand scale involves great vision, great ideas and great execution. While coming up with a plethora of ideas is undoubtedly critical to innovation, many individuals, teams and organizations are lacking insight into how to practically move forward beyond the great idea without losing touch with the overall vision. This article des

Analytical model of beach erosion and overwash during storms

During severe storms high waves and water levels may greatly impact the sub-aerial portion of the beach inducing significant morphological change at elevations that the waves can not reach under normal conditions. Morphological formations such as dunes and barrier islands may suffer from direct wave impact and erode. Overwash occurs if the wave run-up and/or the mean water level are sufficiently h

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from

Lipid emboli distribution in cardiac surgery is dependent on the state of emulsification

Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A sh

Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma

Popular Abstract in Swedish Lymfom är en grupp tumörsjukdomar som uppkommer från de vita blodkropparna i vårt immunförsvar. Diffust storcelligt B-cellslymfom (DLBCL) är en av de mest aggressiva varianterna av lymfom och uppkommer från den typen av vita blodkroppar som kallas B-celler. Varje år drabbas ca 500 personer i Sverige av DLBCL. Typiska symtom är hastigt tillväxande lymfkörtlar samt viktneDiffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous disease. Identification of prognostic and predictive markers is important to design individualised and effective treatment strategies. This thesis describes different approaches to search for molecular prognostic markers and an attempt to overcome chemotherapy resistance in DLBCL. In the first study it was investigated whet

Separation of concerns on the orchestration of operations in flexible manufacturing

The growing complexity of industrial robot work-cells calls for the use of advanced orchestration techniques to promote flexibility and reusability. This paper presents a solution based on service-oriented platforms that endorses the separation of concerns, coordination and execution. The execution is kept inside each individual device and their functionality is exposed via automatic generation of

Single scattering detection in turbid media using single-phase structured illumination filtering

This work shows a unique possibility of visualizing the exponential intensity decay due to light extinction, when laser radiation propagates through a homogeneous scattering medium. This observation implies that the extracted intensity mostly originates from single scattering events. The filtering of this single light scattering intensity is performed by means of a single-phase structured illumina

CSF amyloid beta 38 as a novel diagnostic marker for dementia with Lewy bodies

Background The clinical distinction between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) is sometimes difficult, particularly in mild cases. Although CSF markers such as amyloid beta 42 (A beta 42) and P-tau can distinguish between AD and normal controls, their ability to distinguish between AD and DLB is not adequate. Objective This study aims to investigate whether CSF markers, i

A review of design considerations for light-duty diesel combustion systems

Practical aspects of light-duty diesel combustion system design are reviewed, with an emphasis on design considerations reported by manufacturers and engine design consultancies. The factors driving the selection of compression ratio, stroke-to-bore ratio, and various aspects of combustion chamber geometry are examined, along with the trends observed in these parameters in recently released engine

Nuets förnöjsamhet: en grundad teori om livsval och överlevnadsstrategier

"Contentment in the moment" is a classic grounded theory exploring safety and contentment within a small community in northern Norway. The purpose of the study was to explore the village's everyday life from a participant's perspective and to develop an understanding of their living conditions. We found different survival strategies, which have their roots in the village's history of poverty, isol

Image Processing Architectures for Binary Morphology and Labeling

Conventional surveillance systems are omnipresent and most are still based on analog techniques. Migrating to the digital domain grants access to the world of digital image processing enabling automation of such systems, which means extracting information from the image stream without human interaction. The resolution, frame rates, and functionality in these systems are continuously increasing alo

Factors of importance for maintaining work as perceived by men with arthritis

OBJECTIVE: Employment rates are significantly lower among individuals with arthritis compared to a general population. There is, however, limited research about how men with arthritis perceive their ability to maintain working. The aim of this study was thus to explore their perception of this. PARTICIPANTS: Nine employed men with arthritis were purposively sampled. METHODS: Interviews were perfor

The anomalous hyperfine structure of Al II

The hyperfine structure of a large number of transitions in Al II cannot be described using A and B hyperfine constants and the hyperfine structure is therefore said to be anomalous. In this paper, we have studied the hyperfine structure of a few transitions in Al II, 3s5s(3)S-3s5p(3)P, 3s4d(3)D-3s5p(3)P and 3s5p(3)P-3s5d(3)D, by combining theory and experiment. It is shown that the anomalous hype

Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development

Popular Abstract in Swedish Fibromodulin och dystrofin i ateroskleros; en populärvetenskaplig sammanfattning VAD ÄR ATEROSKLEROS? Ateroskleros – det man tidigare kallade för åderförkalkning – är grundorsaken till hjärtinfarkt, stroke och kärlkramp. Ett aterosklerosplack är en förträngning i ett blodkärl, ofta vid en förgrening där blodflödet är turbulent. Placket börjar ofta växa redan i unga år Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between th