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Validation of fluid-structure interaction simulations of the opening phase of phantom mitral heart valves under physiologically inspired conditions

Background and objectiveAtrioventricular valve disease is a common cause of heart failure, and successful surgical or interventional outcomes are crucial. Patient-specific fluid-structure interaction (FSI) modeling may provide valuable insights into valve dynamics and guidance of valve repair strategies. However, lack of validation has kept FSI modeling from clinical implementation. Therefore, thi

The use of zakat in the pandemic response : the case of Islamic Relief and BAZNAS in Indonesia

This article compares two Islamic organisations, a non-governmental and a national one, in their methods of collecting and distributing zakat, and analyses how they addressed the COVID-19 crisis with these funds in the period 2020–2021. The study examines Islamic Relief as a Muslim non-governmental organisation involved in humanitarian response, and the National Board of the Zakat Republic of Indo

No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner

PurposeThis study aimed to elucidate whether gadolinium contrast in clinically relevant doses can be used with photon-counting computed tomography (PCCT) as an alternative contrast agent in clinical applications.Material/methodsA CTDI phantom with 3D printed rods filled with different concentrations of gadolinium and iodine contrast was scanned in a PCCT and an energy-integrated computed tomograph

Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population

BackgroundCerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel

fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles

In muscular dystrophies, muscle fibers loose integrity and die, causing significant suffering and premature death. Strikingly, the extraocular muscles (EOMs) are spared, functioning well despite the disease progression. Although EOMs have been shown to differ from body musculature, the mechanisms underlying this inherent resistance to muscle dystrophies remain unknown. Here, we demonstrate importa

Light-yield response of liquid scintillators using 2–6 MeV tagged neutrons

Knowledge of the neutron light-yield response is crucial to the understanding of scintillator-based neutron detectors. In this work, neutrons from 2–6 MeV have been used to study the scintillation light-yield response of the liquid scintillators NE 213A, EJ 305, EJ 331 and EJ 321P using event-by-event waveform digitization. Energy calibration was performed using a GEANT4 model to locate the edge p

Structure and thermoacoustic instability of turbulent swirling lean premixed methane/hydrogen/air flames in a model combustor

The structure and thermoacoustic instability (TI) of premixed CH4/H2/air swirling flames were experimentally investigated for a range of hydrogen fraction (ηH2) up to 80% under different equivalence ratio (Φ) and swirl number (S) conditions. It is shown that the onset of TI is enhanced when increasing either ηH2, S, or Φ. The dominant frequency of TI increases dramatically with ηH2. The higher dom

Assessing the carcinogenic and non-carcinogenic health risks of metals in the drinking water of Isfahan, Iran

Metals are significant contributors to water pollution, posing serious threats to human health. This study aims to assess the carcinogenic and non-carcinogenic health risks associated with metals in Isfahan drinking water. Eighty water samples were randomly collected from the city's distribution network between January and March 2020–2021. Inductively coupled plasma Optical Emission Spectrometry w

Doping-dependent charge- and spin-density wave orderings in a monolayer of Pb adatoms on Si(111)

In this work we computed the phase diagram as a function of temperature and doping for a system of lead adatoms allocated periodically on a silicon (111) surface. This Si(111):Pb material is characterized by a strong and long-ranged Coulomb interaction, a relatively large value of the spin-orbit coupling, and a structural phase transition that occurs at low temperature. In order to describe the co

Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study

Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38

Reality-Theoretical models-Mathematics: A ternary perspective on physics lessons in upper-secondary school

This article discusses the role of mathematics during physics lessons in upper-secondary school. Mathematics is an inherent part of theoretical models in physics and makes powerful predictions of natural phenomena possible. Ability to use both theoretical models and mathematics is central in physics. This paper takes as a starting point that the relations made during physics lessons between the th

An attempt to investigate the use of mathematics in physics classrooms

We outline a framework to study the use of mathematics in physics classrooms. The framework focuses on the relations made between Reality, Theoretical models and Mathematics. In this paper the analyses of one teacher and her 3rd year classes at secondary school are presented. The results show that phenomena in reality are often used as a short prelude to put focus on the relationship theoretical m

Lagspråk och skriftlighet : Det formella skriftspråkets konstruktionssyntax som grund för lagspråksförenkling och EU-översättning

Den här boken handlar om de lexikogrammatiska förutsättningarnaför välfungerande och rimligt lättillgängliga inhemska lagtexter ochöversatta EU-rättsakter och -domar. Bokens huvudtes är attspråkformen i bägge fallen måste grundas på skriftlighet, dvs. på ettkvalificerat bruk av hela det formella skriftspråketskonstruktionsregister och med strikt tillämpning av dess generellanormsystem. Boken vände

Flexibility and coordination among acts of visualization and analysis in a pattern generalization activity

This study aims at exploring processes of flexibility and coordination among acts of visualization and analysis in students’ attempt to reach a general formula for a three-dimensional pattern generalizing task.The investigation draws on a case-study analysis of two 15-year-old girls working together on a task in which they are asked to calculate the number of blocks in a three-dimensional tower of

Disk counting statistics near hard edges of random normal matrices : The multi-component regime

We consider a two-dimensional point process whose points are separated into two disjoint components by a hard wall, and study the multivariate moment generating function of the corresponding disk counting statistics. We investigate the “hard edge regime” where all disk boundaries are a distance of order [Formula presented] away from the hard wall, where n is the number of points. We prove that as

Microbial composition, functionality, and stress resilience or susceptibility : unraveling sex-specific patterns

Background: Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging eviden