Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or granules and can therefore only be used for extracellular drug release. This shortcoming could be overcome with the use of cell penetrating HA nan

Subgap states are responsible for the low-bias transport features of hybrid superconducting-semiconducting devices. Here we analyze the local and nonlocal differential conductance of Coulomb-blockaded multiterminal superconducting islands that host subgap states with different spatial structures. The emerging patterns of their transport spectroscopy are used to characterize the possible topologica

Syftet med denna uppsats är att undersöka hur avvägningen mellan effektivitet och rättssäkerhet i förarbetena till skattetillägget kommit att påverka hur dagens skattetillägg fungerar i praktiken vid Skatteverkets kontrollverksamhet avseende tjänsteavdrag. Detta redogörs för genom att dagens regelverk och de förarbeten som legat till grund för skattetillägget analyseras i förhållande till effektivThe purpose of this essay is to investigate how the trade-off between efficiency and rule of law during the legislation processes for the tax surcharge has come to affect how today's tax surcharge works in practice regarding the Swedish Tax Agency's monitoring of tax deductions for work-related expenses made by natural persons. This essay will examine this through analyzing today's reg

When restrictions and rationing took effect during the Second World War, home sewing became a necessity for many women. This paper presents and discusses the distribution of paper patterns for home sewing in Sweden during the war years, using the examples of three different pattern magazines. It shows how these magazines conveyed, interpreted, and adapted fashion to home sewers. Despite the fact t

Samverkan har sedan lång tid tillbaka varit viktigt inom både regionala ochkommunala verksamheter och det finns mycket som talar för attsamverkansbehoven kommer att öka än mer. Inom hälso- och sjukvården finns en kontinuerlig utveckling mot ny och mera specialiserad kunskap som även fårorganisatoriska konsekvenser. Teamarbete i vården har blivit allt viktigare, liksom nivåstrukturering och koncentCooperation has long been important within both regional andmunicipal activities and there is much to suggest thatcollaboration needs will increase even more. Within health care there is onecontinuous development towards new and more specialized knowledge that also gains organizational consequences. Teamwork in healthcare has become increasingly important, as well level structuring and concentrati

Models of statistical discrimination typically assume that employers make rational inference from (education) signals. However, there is a large amount of evidence showing that most people do not update their beliefs rationally. We use a model and two experiments to show that employers who are conservative, in the sense of signal neglect, discriminate more against disadvantaged groups than Bayesia

Den svenska vittnesplikten innebär en skyldighet för vittnen, att inför domstol berätta sitt vittnesmål sanningsenligt. Vittnesplikten kan som utgångspunkt åläggas den som har information av värde för domstolens dömande verksamhet och är minst 15 år. Utifrån den betydelse vittnesmålet har för det allmännas intresse av brottsbekämpning, möjliggörs att vidta åtgärder för att förmå ett vittne att fulThe Swedish duty to testify entails an obligation for the witness to tell their testimony truthfully before the court. A person can be required to testify from the age of 15 if they have information of value for the court’s administration of justice. Based on the importance of the testimony for the public interest in law enforcement, it is possible to take measures to compel a witness to fulfill t

A model is used to describe a system physically or mathematically and to give information about changes in the system variables. Physical knowledge about the system and its quantities can be useful to build a physical model obeying the laws of nature. However, if the system is to be regarded as a black box with only input and output signals, system identification can be used to fit a mathematical

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast can

This special issue of the AJCH celebrates the life and work of Professor Irving Kirsch (Figure 1; my gratitude to the contributors, to Journal Editor-in-Chief, Stephen R. Lankton, and to Irving Kirsch, who provided me with information and photographs). I decided to organize this tribute not only because Professor Kirsch has been a towering figure in hypnosis and related areas, but because he has b

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

An enhanced flamelet generated manifold (FGM) model for large eddy simulation (LES) of turbulent spray combustion is presented. In the enhanced FGM model, a transported probability density function (TPDF) description of the FGM variables is employed. The TPDF is represented using the Eulerian stochastic fields (ESF) approach, and the method is applied to LES of spray combustion under conditions re

The frst May Measurement Month (MMM) campaign, a global blood pressure (BP) screening programme, began in 2017 as an initiative of the International Society of Hypertension.1 Two subsequent annual campaigns have also been completed in consecutive years2,3 and having had to defer activities due to the COVID-19 pandemic in 2020 the fourth campaign was run in 2021, the results of which are currently

Uppsatsen ämnar klargöra när patienter inom psykiatrisk tvångsvård lagligen kan delta i medicinsk forskning om psykiatrisk tvångsvård. En patient inom psykiatrisk tvångsvård kan nämligen vara förhindrad att lämna giltigt samtycke till deltagande i forskning mot bakgrund av sitt psykiska tillstånd och att den kan känna sig tvingad att delta då den befinner sig inom tvångsvården. I lagen (2003:460) This essay aims at clarifying when patients in compulsory psychiatric care can be included in medical research projects concerning compulsory psychiatric care. A patient in compulsory psychiatric care could be unable to provide valid consent to participate in research due to their mental state and the fact that they can feel obliged to consent since they are in compulsory care. The Ethical Review