Pure 1′#,2′,3′,4′#,5′,5′'-2H6-ribonucleoside derivatives 10–14, 1′#,2′,″,3′,4′#,5′,5″-2H7-2′-deoxynucleoside blocks 15–18 and their natural-abundance counterparts were used to asemble partially deuterated ribonucleotide-dimers (∗ indicates deuteration at 1′#,2′,3′,4′#,5′,5″(2H6)): ApU∗21, GpC∗22 partially deuterated 2′-deoxyribonucleotide-dimers d(TpA∗) 23, d(ApT∗) 25, d(GpC∗26 (∗ indicates deuter

The first synthesis of a non-uniformly deuterium labelled 21mer RNA is reported using our ‘NMR-window’ concept, showing its unique application in the unambiguous NMR assignment of the non-exchangeable aromatic and sugar protons.

Evaluations provide insights into the effectiveness of emergency exercises or the response to a disaster. A well-constructed process is key to capture evidence-based feedback that can support future learning and development. However, little is known about how they are performed in practice and whether they actually meet their intended purpose. Therefore, this paper provides an overview of how ‘ope

This thesis is composed out of five papers that deal with various problems intheoretical particle physics. While paper I is a precision calculation in aneffective theory of the Standard Model, paper II to V all deal with beyond theStandard Model physics. Paper IV is a manual for the tools developed during ourwork on paper II to V.Paper I. We calculate the 2-loop soft function for the transverse moThis thesis is composed out of five papers that deal with various problems intheoretical particle physics. While paper I is a precision calculation in aneffective theory of the Standard Model, paper II to V all deal with beyond theStandard Model physics. Paper IV is a manual for the tools developed during ourwork on paper II to V.Paper I. We calculate the 2-loop soft function for the transverse mo

Background and study aims Endoscopic submucosal dissection (ESD) allows en bloc resection of large colorectal lesions but ESD experience is limited outside Asia. This study evaluated implementation of ESD in the treatment of colorectal neoplasia in a Western center. Patients and methods Three hundred and one cases of colorectal ESD (173 rectal and 128 colonic lesions) were retrospectively evaluate

This dissertation provides a career perspective on entrepreneurship based on the research question: “How do organizational bureaucracy and relative income affect the career choice of entrepreneurship among employees from the science and technology labor force (STLF); and what are the career outcomes in terms of returns during, and post entrepreneurship on re-entry into paid employment?” More speci

BACKGROUND: The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Intérieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stratified across five decades of life (age 20-69), w

Context. In the era of large high-resolution spectroscopic surveys such as Gaia-ESO and APOGEE, high-quality spectra can contribute to our understanding of the Galactic chemical evolution by providing abundances of elements that belong to the different nucleosynthesis channels, and also by providing constraints to one of the most elusive astrophysical quantities: stellar age. Aims. Some abundance

Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chro

The growth of 10 isolates of rhizosphere bacteria was compared in the rhizoplane (RP), rhizosphere (RS) and non-rhizosphere soil of a model system with rape seedlings growing in sterile sand. The colonization of the RP differed little among isolates. However, the bacterial isolates differed according to their degree of dependence on the root for growth, as judged by RS:RP and plant:non-plant ratio

An autoclavable all-glass system for studying microbial dynamics at permeable surfaces is described. Standard hydrophobic or hydrophilic membranes (46-mm diameter) of various pore sizes were supported on a glass frit through which nutrient solutions were pumped by a peristaltic pump. The pump provided a precisely controlled flow at speeds of 0.5 to 500 ml of defined or natural cell exudates per h,

Sensitive detection of cellular components from specific groups of microbes can be utilized as 'signatures' in the examination of microbial consortia from soils, sediments or biofilms. Utilizing capillary gas chromatography/mass spectrometry and stereospecific derivatizing agents, D-alanine, a component localized in the prokaryotic (bacteria) cell wall, can be detected reproducibly. Enrichments o

Magnetic resonance imaging (MRI) permits the visualization of anatomical structures not appreciated by conventional radiographic imaging, and may assess inflammatory disease and its progression with greater sensitivity than conventional radiography. In this study of 30 patients with early rheumatoid arthritis (RA), which could be considered as a pilot study because of the relatively small number o

Med tillitsbaserad styrning och ledning vill vi öka möjligheten för medarbetare att använda sitt professionella omdöme. Detta utrymme påverkas emellertid inte bara av styrningen, utan även av kulturen i organisationen och i sektorn i stort. För att bidra till en god förvaltningskultur bedriver idag de flesta offentliga organisationer ett strukturerat värdegrundsarbete. Många myndigheter väljer att

Uppföljning är nödvändig i alla verksamheter. Det finns emellertid mycket som tyder på att vi lägger alltför stora resurser på uppföljning och att vi dessutom följer upp på fel sätt. I denna rapport diskuterar jag hur uppföljning kan utformas för att bidra till ökad tillit i allmänhet och ökad tillit till de medborgarnära professionerna i synnerhet, inom ramen för offentliga organisationer. Jag sl