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Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells

OBJECTIVE: Although clinically approved for myelodysplastic syndromes (MDS), the mode of action of 5-azacytidine has not been well understood at the cellular level. The present study aimed at characterizing the mechanisms for 5-azacytidine-induced apoptosis, as well as the presence of a possible link between apoptosis and DNA hypomethylation. MATERIALS AND METHODS: We investigated the effects of 5

Population variability in space and time

One of the most ubiquitous phenomena of all natural populations is their variability in numbers in space and time. However, there are notable differences among populations in the way the population size fluctuates. One of the major challenges in population and community ecology is to explain and understand this variety and to find possible underlying rules that might be modified from case-to-case.

Molecularly emprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond

Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed

My family dies from heart attacks. How hypercholesterolaemic men refer to their family history

Patients often worry considerably about biomedically mild and self-limiting conditions. A previous study on non-selected primary care patients showed that this could be partly explained by frequent associations with cases of serious illness in their family histories. This study further investigated these phenomena in middle aged men with a recent diagnosis of hypercholesterolaemia. Sixty-three out

Nursing care at night: An evaluation using the night nursing care instrument

Introduction Night nurses carry overall nursing responsibility for approximately half the time that patients spend in hospital. However, there is a paucity of literature that focuses on nursing care provided at night. Aim The aim of this study was to evaluate nursing care provided at night from the perspective of both nurses and patients. Methods The study, which had an evaluative and a comparativ

Experimental investigation of delayed self-interference for single photons

A photon echo experiment has been performed using accumulated highly attenuated laser pulses. We show experimentally that the photon echo process can be performed with, on the average, less than one photon in each pair of excitation pulses. The results support an interpretation where this nonlinear process can be performed with, on the average, less than one photon shared between two of the optica

Automatic generation of a detailed mechanism for the oxidation of n-decane

A single detailed kinetic mechanism for the oxidation and combustion of n-decane and n-heptane has been written by means of an automatic mechanism generator ( REACTION) developed in our laboratory. It shows a good prediction of the ignition delay time versus temperature for the oxidation of n-decane at 13 and 50 bar and n-heptane at 13 and 40 bar for different equivalence ratios. The n-decane/n-he

Variation in host specificity between species of avian hemosporidian parasites : Evidence from parasite morphology and cytochrome B gene sequences

A parasite's shift to a new host may have serious evolutionary consequences, since host switching usually is associated with a change in virulence and may lead to the evolution of emerging diseases. This phenomenon remains insufficiently studied in wildlife. Here, we combine microscopic examination of blood films and PCR-based methods to investigate the natural host specificity of Haemoproteus and

Second forerunners in reflection and transmission data

Second forerunner approximations to the transmission and reflection kernels for a temporally dispersive, nonmagnetic, isotropic slab are obtained. Numerical results are presented for two different dispersion models and are compared with the second forerunner approximations. Finally, transmission and reflection kernels are used to reconstruct the first susceptibility moments of the material of the

The Yakubovich-Kalman-Popov Lemma and Stability Analysis of Dynamic Output Feedback Systems

This paper presents theory related to stability analysis and stability criteria relevant for observer-based feedback control systems. To this purpose, a special formulation of the Yakubovich-Kalman-Popov (YKP) lemma is provided. We exploit that controllability is not necessary for existence of Lur'e-Lyaptinov functions as used in stability criteria. Constructive means for dynamic output feedback s

Integrated modeling of the Euro50

The Euro50 is a proposed 50 m optical and infrared telescope. It will have thousands of control loops to keep the optics aligned under influence of wind, gravity and thermal loads. Cross-disciplinary integrated modeling is used to study the overall performance of the Euro50. A sub-model of the mechanical structure originates from finite element modeling. The optical performance is determined using

Smärtans ansikte : för en ikonisk passionsfenomenologi

Hur ser smärtan ut? Smärtan känns. Det vet varje människa. Men hur förhåller det sig med dess synlighet? Går smärtan att avbilda? ”I wanted to paint the scream more than the horror”, förklarade Francis Bacon, smärtans och fasans okrönte mästare som på duk efter duk avbildade skrikande, ångestridna och vanställda kroppar. Och är det inte precis så det förhåller sig med våra försök att avbilda smärt

Nanocapillary liquid chromatography interfaced to tandem matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry: Mapping the nuclear proteome of human fibroblasts.

Miniaturized liquid chromatography nanoseparation in combination with minigel fractionation of human primary cell nuclei is presented. We obtained high-sensitivity and high-throughput identification of expressed proteins by subcellular fractionation and nanocapillary liquid chromatography interfaced to both electrospray ionization (ESI)- and matrix-assisted laser desorption/ionisation (MALDI) tand

Results of a randomized, population-based study of biennial screening using serum prostate-specific antigen measurement to detect prostate carcinoma

BACKGROUND. The purpose of the current study was to evaluate the effectiveness of a prostate carcinoma screening program in which serum prostate-specific antigen (PSA) levels were measured. METHODS. From a group of 20,000 men born between January 1, 1930, and December 31, 1944, 10,000 men were randomized into a screening group and 10,000 were randomized into a control group. Patients in the screen

Impact of operative time and surgeon satisfaction on the long-term outcome of hernia repair

The aim of this study was to assess the impact of the degree of difficulty and quality of hernia repair, as perceived by the surgeon, and operative time on the reoperation rate. All hernia repairs performed during the period 1994-1995 at the Department of Surgery, University Hospital of Lund, Sweden, were recorded prospectively. The degree of difficulty and the degree of difficulty in relation to