Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease,ADAMTS 13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS 13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP. The 4143insA mutation is unusual with respect to its geographic concentration.

The kinetics of oxidation of hydroxylamine by iron() have been studied spectrophotometrically. The effects of pH, reactant and product concentrations led to two experimental rate expressions. The results obtained are consistent with a mechanism dependent on the relative iron(III)-to-hydroxylamine concentrations; an excess of iron() gives a stoichiometry of 2 : 1 for the total reaction and N2O as t

The reported rate of detection of Chlamydia pneumoniae DNA within atherosclerotic lesions by PCR varies between 0 and 100%. In this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of PCR. The positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of C. pne

The paper analyses the behaviour of convergence/divergence primarily within Western Europe and the OECD in relation to market integration and to major technological shifts such as the second and the third industrial revolution. It also relates the behaviour to traditional growth theory and endogenous growth theory as well as to historical generalisations based on structural analysis. The empirical

As a component of herbicides, the fate of glyphosate (PMG) in the environment is of significant interest. The nature of PMG adsorption on mineral surfaces plays a significant role in the degradation of PMG. The adsorption of PMG on goethite (alpha-FeOOH) has been studied as a function of pH and PMG concentration. Adsorption was investigated with batch experiments, attenuated total reflectance Four

Numerical simulations of two-phase fluid flow and heat transfer with or without phase change have been carried out. The Volume-of-Fluid (VOF) model was used in the simulations, and a procedure for considering the phase change process was developed. The Piecewise Linear Interface Calculation (PLIC) method is employed for the interface reconstruction, to keep the sharp interface. The coupling betwee

Sonographic pictures of the brain of 19 newborn infants who died at a mean age of 4.2 days after birth (range 1-23 days) were examined independently by five experienced sonographers. In all infants information on postmortem brain pathology was available. Diagnoses made by the sonographers based on the sonographic pictures were compared with the gross postmortem findings. The results of the study s

OBJECTIVE—To monitor glycemic control, treatable risk factors, and treatment profile for quality assessment of diabetes care on a national scale. RESEARCH DESIGN AND METHODS—Four samples of 23,546, 32,903, 30,311, and 29,769 patients with diabetes (1996–1999) were studied based on a repeated national screening and quality assessment of diabetes care by the National Diabetes Register, Sweden, with

Polymers containing the Azo-benzene group have attracted attention due to anticipated uses such as materials for data storage, membranes with controllable permeability and materials with changeable solubility [1,2]. These expectations are due to the change in shape and dipole moment of the Azo-compound when excited by photo isomerization from the trans-state to the cis-state by UV light of ca 360

Inversion recovery (T-1) and microwave power saturation studies have been performed, between 4 and 25 K, on the EPR signal from the stable tyrosyl radical, Y-D(.), in photosystem II core complex preparations from higher plants. Measurements are reported from the dark stable S-1 and first turnover S-2 states of the photosystem catalytic Mn cluster and in two cryoprotectant regimes; sucrose and ethy

BACKGROUND: Previous studies of associations between diet, obesity, and blood concentrations of alpha-tocopherol and beta-carotene have been equivocal. Furthermore, most studies used only body mass index (BMI) as an obesity measure. OBJECTIVES: Our objectives were to examine the associations between energy and nutrient intakes, alcohol consumption, tobacco use, and serum cholesterol and serum conc

Did life change after treatment? How did it change? Evaluations of in-treatment programs for drug abusers are usually designed to discover effects of treatment on the client´s drug use. This report presents a follow-up study with a broader perspective. Rehabilitation from drug abuse is seen as a radical or gradual change of life course and identity, interrelated to changes in social conditions. Ma

Two experiments have been performed using the Ni-58(S-32,3p) reaction at 135 MeV with Gammasphere and the Microball to study the high-spin structure of the transitional nucleus Nb-87. The first experiment using a thin target provided a considerable extension and refinement of the level scheme, as well as firm spin assignments from directional correlation of oriented nuclei. Sub-picosecond lifetime

Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demo

Popular Abstract in Swedish Denna avhandling innehåller fem essäer behandlande ett antal olika frågor inom området empirisk finansiell ekonomi. Genom användandet av kvantitativa metoder är syftet att studera praktiskt relevanta problem relaterade till hur finansiella marknader fungerar. Frågorna som tas upp sträcker sig från optionsprissättning och terminshedgning, över stokastisk volatilitets modThis thesis consists of five empirical essays dealing with different issues related to financial markets. Chapter 2 studies a new multivariate technique, Orthogonal GARCH, of forecasting large covariance matrices based on GARCH models. Orthogonal GARCH is built on principal component analysis and makes the creation of positive definite covariance matrices of arbitrary size possible. An important d