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The increasing influence of siblings in social mobility. A long-term historical view (Barcelona area, 16th-19th centuries)

Parental influence over children’s status attainment has historically been argued to be key. However, the cross-sibling influence has been scarcely studied for historical periods and for steam family societies, being the most long-lasting relationship across individuals’ lives once childhood was surpassed. We investigate how intra-generational family relationships determine the social destiny of s

Total Synthesis of (−)-Glionitrin A and B Enabled by an Asymmetric Oxidative Sulfenylation of Triketopiperazines

Asymmetric construction of dithiodiketopiperazines on otherwise achiral scaffolds remains a pivotal synthetic challenge encountered in many biologically significant natural products. Herein, we report the first total syntheses of (−)-glionitrin A/B and revise the absolute configurations. Emerging from the study is a novel oxidative sulfenylation of triketopiperazines that enables asymmetric format

Efficient Solvers for Space-Time Discontinuous Galerkin Spectral Element Methods

In this thesis we study efficient solvers for space-time discontinuous Galerkin spectral element methods (DG-SEM). These discretizations result in fully implicit schemes of variable order in both spatial and temporal directions. The popularity of space-time DG methods has increased in recent years and entropy stable space-time DG-SEM have been constructed for conservation laws, making them interes

Estimation of baseline levels of bacterial community tolerance to Cr, Ni, Pb, and Zn in unpolluted soils, a background for PICT (pollution-induced community tolerance) determination

The PICT method (pollution-induced community tolerance) can be used to assess whether changes in soil microbial response are due to heavy metal toxicity or not. Microbial community tolerance baseline levels can, however, also change due to variations in soil physicochemical properties. Thirty soil samples (0–20 cm), with geochemical baseline concentrations (GBCs) of heavy metals and from five diff

Epigenome-Wide Histone Acetylation Changes in Peripheral Blood Mononuclear Cells in Patients with Type 2 Diabetes and Atherosclerotic Disease

There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D) and advanced atherosclerotic disease. We performed chromatin immunoprecipitation sequencing (ChIP-seq) using a histone 3 lysine 9 acetylation (H3K9ac) mark in peripheral blood mononuc

Respiratory rate modulation improves symptoms in patients with pulmonary hypertension

Background: Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are chronic diseases with a severe symptom burden. Common symptoms are dyspnoea at light activity and general fatigue that limits daily activities. Respiratory modulation by device-guided breathing decreased symptoms in patients with heart failure. The aim of this pilot study was to investigate if respira

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Checkpoints er fremtrædende og helt uomgængelige i nye syriske romaner skrevet i krigsårene. Checkpoint(s) (ḥājiz – pl. ḥawājiz) er en del af det nye litterære ordforråd efter 10 år med opstand og konflikt. Checkpointene er centrale elementer i de landskaber historierne udspiller sig i, de styrer den narrative struktur og tydeliggør væsentlige temaer i den tilværelse i krig, litteraturen fremstillCheckpoints are prominent and completely unavoidable in new Syrian novels depicting the war years. Checkpoint (s) (ḥājiz / ḥawājiz) are part of the new literary vocabulary after ten years of revolt and conflict. The checkpoints are central elements in the landscapes in which the stories take place, they guide the narrative structure, and accentuate essential themes in the life in war. Confrontatio

Receptors for hematopoietic regulatory cytokines : overview of structure and function

The production of blood cells is regulated by the action of external factors, cytokines, that can be released by many cell types. In the first place, a population of multipotent stem cells, mostly in the resting Go phase of the cell cycle, but with self-renewal capacity, gives rise to progenitor cells that are predetermined for differentiation into all kinds of blood cells. Expression of genes for

Contamination Issues in Ambient Pressure Experiments

Contamination is the most common and arguably the most significant problem scientists are facing in experimental surface science research that is practiced in the presence of gases. It is fair to say that contamination problems are often worse with ambient pressures compared to conventional experiments in vacuum. It is one of the main reasons for poor reproducibility in this field and in relevant

Expansion by migration and diffusion by contact is a source to the global diversity of linguistic nominal categorization systems

Languages of diverse structures and different families tend to share common patterns if they are spoken in geographic proximity. This convergence is often explained by horizontal diffusibility, which is typically ascribed to language contact. In such a scenario, speakers of two or more languages interact and influence each other’s languages, and in this interaction, more grammaticalized features t

Unsolved Asymmetries and Complex Productive Structures in the Eurozone

The severity of the crisis in the Southern Eurozone countries is frequently attributed to inflated economies and reckless spending. Thus, it isn’t surprising that the main interpretation is that the crisis ought to be solved by decreasing government spending and lowering wages. This paper argues, instead, that one of the core underlying reasons for the severity of the crisis in the Southern Eurozo

Structural Change Deconstructed: A Centre-Periphery Divide in Europe

After more than a decade since the outbreak of the financial crisis, overall economic growth in the Eurozone is still disappointing. An increasing group of economists attributes the inadequate economic performance to large and deeply engrained differences between the productive structures of the Northern and Southern Eurozone. To find out whether there is reason to believe this, we apply the Econo

Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus

Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfu

Positioning and Sensing for Vehicular Safety Applications in 5G and beyond

This article presents a shared vision among stakeholders across the value chain on the use of radio positioning and sensing for road safety in the 5G ecosystem. The key enabling technologies and architectural functionalities are explored, focusing on the extremely stringent localization and communication requirements. A case study for joint radar and communication using experimental data showcases

Experimental Exploration of Unlicensed Sub-GHz Massive MIMO for Massive Internet-of-Things

IoT networks are getting overcrowded following the vast increase in number of Internet-of-Things (IoT) devices and connections. Networks can be extended with more gateways, increasing the number of supported devices. However, as investigated in this work, massive MIMO has the potential to increase the number of simultaneous connections and moreover lower the energy expenditure of these devices. We