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Determination of hexahydrophthalic and methylhexahydrophthalic acids in urine by gas chromatography-negative-ion chemical-ionisation mass spectrometry

A method for determining hexahydrophthalic (HHP acid) and methylhexahydrophthalic acids (MHHP acid) from human urine was developed. These acids are metabolites of the highly sensitising hexahydrophthalic anhydride and methylhexahydrophthalic anhydride. The acids were purified from urine by liquid-solid extraction and derivatised with pentafluorobenzyl bromide to the corresponding esters. These wer

Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods

Popular Abstract in Swedish Redan för 5000 år sedan i det antika Egypten användes ljus för att behandla vissa hudåkommor. Denna bortglömda kunskap återupptäcktes i början av förra seklet men fick inget riktigt genomslag. De senare årtiondenas framsteg inom kemi och fysik har återigen gjort ljusbehandling av sjukdomar högintressant. Speciellt upptäckten av lasern på 1960-talet har gjort att tillämpSince cancer continues to plague humanity there is large need for development of modalities for both diagnosis and therapy. Most of the currently available methods suffer from serious disadvantages. The treatments, e.g. ionising radiation, chemotherapy, surgery, may themselves induce malignancies or the patient may be physically impaired for a longer period of time. The work presented aims at dev

Blood redistribution in the fetal brain during chronic hypoxia

Background Studies on blood flow velocity in the fetal middle cerebral artery have revealed signs of brain sparing in chronic hypoxia. These signs of brain sparing can disappear in the terminal case, but whether this applies to the whole brain or only parts of it is unknown. Methods Velocity waveforms of the middle cerebral, anterior cerebral and posterior cerebral arteries were recorded in 221 pr

Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction

The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another stud

Electronic structure of lithium-doped anatase TiO2 prepared in ultrahigh vacuum

Insertion of lithium in anatase TiO2, giving LixTiO2, is performed under ultrahigh vacuum (UHV) conditions and studied using synchrotron radiation based electron spectroscopy. Core level photoemission spectra are directly compared to results obtained after electrochemical insertion, illustrating the usefulness of the UHV approach. The growth of a state of mainly Ti 3d character in the band gap is

Stress management in men with solvent-induced chronic toxic encephalopathy

Stress management was studied in male patients with solvent-induced chronic toxic encephalopathy (TE) of types 2A (TE 2A, n = 31) and 2B (TE 2B, n = 26). The patients were compared with a healthy reference group (n = 57). Self-reported symptoms (90-item Symptoms Checklist [SCL-90]), sense of coherence, coping strategies, and level of mastery were measured. As expected, both TE groups reported high

Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity

ATP-sensitive K(+) channels (K(ATP) channels) of pancreatic beta-cells play key roles in glucose-stimulated insulin secretion by linking metabolic signals to cell excitability. Membrane phosphoinositides, in particular phosphatidylinositol 4,5-bisphosphates (PIP(2)), stimulate K(ATP) channels and decrease channel sensitivity to ATP inhibition; as such, they have been postulated as critical regulat

Amplitude-integrated encephalography in pyridoxine-dependent seizures and pyridoxine-responsive seizures.

Pyridoxine-dependent seizures are rare in newborn infants, although recent data suggest that the prevalence probably is underestimated. In all newborn infants with recurrent epileptic seizures the general recommendation is to administer pyridoxine and simultaneously record an electroencephalogram (EEG). Conclusion: One infant with pyridoxine-responsive seizures and another with pyridoxine-dependen

Modelling the vegetation of China using the process-based equilibrium terrestrial biosphere model BIOME3

1 We model the potential vegetation and annual net primary production (NPP) of China on a 10' grid under the present climate using the processed-based equilibrium terrestrial biosphere model BIOME3. The simulated distribution of the vegetation was in general in good agreement with the potential natural vegetation based on a numerical comparison between the two maps using the DeltaV statistic (Delt

Ballaststudier

Innehåll: Forskningsbehov inom ballastområdet; Lättballast ; Ballastens funktion i betong ; Testmetoder och kvalitetskriterier för ballast till betong

Numerisk simulering av detektionsmiljö med fältmodeller

För att kunna beräkna tiden till aktivering av en rökdetektor krävs en beskrivning av strömnings- och temperaturförhallandena samt röktätheten i detektorns omgivning. Den transienta utvecklingen av strömnings-, temperatur- och koncentrationsförhållandena i ett rum med en brandkälla och av godtycklig geometri kan simuleras med hjälp av sk fältmodeller. I denna rapport presenteras resultaten fran en

The interaction between PEO-PPO-PEO triblock copolymers and ionic surfactants in aqueous solution studied using light scattering and calorimetry

Properties of nonionic triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) (EOnPOmEOn) in aqueous solution and their interaction with the ionic surfactants sodium dodecyl sulfate and hexadecyltrimethylammonium chloride have been investigated by static and dynamic light scattering, high sensitivity differential scanning, and isothermal titration calorimetry. The studie