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Effects of disease-modifying antirheumatic drugs on macrophage signal transduction and the induction of proinflammatory cytokines

Popular Abstract in Swedish Ledgångsreumatism (reumatoid artrit) är en allvarlig inflammatorisk led- och systemsjukdom som drabbar ungefär 1% av befolkningen. Den är sannolikt den vanligaste behandlingsbara orsaken till invaliditet i västerlandet. Under de senaste 10 åren har allt fler forskare uppmärksammat sjukdomens dåliga prognos och manat till en tidigare och mera effektiv behandling så snartRheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is

Use of hecate-chorionic gonadotropin beta conjugate in therapy of lutenizing hormone receptor expressing gonadal somatic cell tumors

Improvement of cancer treatment is a major challenge of medical research. Despite the immense efforts made in the improvement of diagnosis and treatment, cancer remains a major concern and cause of morbidity and mortality. Most of the modern anti-neoplastic therapies have severe side effects, and tumor cells often develop drug resistance. There is promise in the new generation of treatments (gene

Experimental and theoretical surface core-level shifts of aluminum (100) and (111)

The surface core-level shifts of Al(111) and Al(100) have been measured using high-resolution core-level photoemission spectroscopy and calculated using density functional theory (DFT). For Al(100), the 2p core-level shift of the first (second) layer was determined to be –75 meV (+20 meV) from experiment and –71 meV (+20 meV) from the DFT calculations. For Al(111), the corresponding values are –27

Searches for New Physics in Single Photon Events and a Search for Charginos at the DELPHI Experiment

Popular Abstract in Swedish Den teoretiska beskrivningen av materians minsta beståndsdelar, den så kallade standardmodellen (SM), överenstämmer med oerhörd noggrannhet med de många och avancerade partikelfysik-experiment som utförts världen över. Trots denna överenstämmelse finns problematiska aspekter hos SM som gör att den inte kommer kunna beskriva fysikaliska fenomen vid högre energier, som änA search for new physics using events with a single photon and missing energy has been made at the DELPHI experiment together with a search for charginos. The results were based on data collected up to and including the final year of 2000. An integrated luminosity of 650 pb^-1 was used in the single photon analysis and 450 pb^-1 in the chargino search. Center-of-mass energies up to 209 GeV were ex

Exponential Vector Field Tomography

In the exponential Radon transform in R2, the integrals of a scalar function f over lines, with exponential weight functions, are determined. We demonstrate how to define two different kinds of exponential Radon transforms for vector fields in R2 in a natural way. It is shown that having data from these transforms it is possible to reconstruct the vector field uniquely. The motivation for the stud

Improved Temperature and Depth Control During FSW of Copper Canisters Using Feedforward Compensation

The welding procedure to seal copper canisters requires variable power input throughout the 45 minute long weld cycle to keep the probe temperature within the process window. By using a cascaded loop that determines the power input requirement, the controller will not be dependent on repeatability in the necessary power input between weld cycles, and the lag time in the probe temperature measureme

Åtgärder för att gynna biologisk mångfald i slättbygder - En kunskapssammanställning

Trots att jordbrukslandskapet enbart utgör en liten andel av Sveriges totala yta så är många av de arter som minskat i antal och utbredning knutna till just detta. Om inte förlusten av biologisk mångfald i jordbrukslandskapet bryts kan detta leda till att Sverige inte lever upp till konventionen om biologisk mångfald och till att viktiga ekosystemtjänster i jordbrukslandskapet som pollination och

"The Catholic Danger”: The Changing Patterns of Swedish Anti-Catholicism 1850-1965

In the 1860s, Sweden’s harsh religious legislation was liberalised. The Dissenter Act legalised conversions to other Christian denominations, but it put in place many obstacles to leaving the established church, and many of the legal restrictions were obviously anti-Catholic in intent. Anti-Catholic sentiment was also expressed in conjunction with the legislative proposals and parliamentary debate

Anxiety in Individuals with ASD: Prevalence, Phenomenology, Etiology, Assessment, and Interventions

Individuals with autism spectrum disorder (ASD) experience high levels of anxiety symptomatology with an estimated prevalence rate of anxiety disorders as high as 40 %. It is likely that anxiety is prominent in individuals with ASD throughout the life-span and that factors such as age, IQ, and ASD symptoms may influence the rates, symptoms, or anxiety subtypes. The high comorbidity rate of anxiety