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China is a global leader in the manufacturing of clean energy. Unexpectedly, the severe environmental degradation occurring since the 1990s and the critical air pollution situation are now under control. Many steps still need to be taken in order to fix all the problems linked with the long-term environmental crisis. However, since Xi Jinping’s advent to power in 2012, Beijing has undertaken a sol
Introduction: Anxiety disorders are common and debilitating in children and adolescents. Cognitive behavioral therapy (CBT), delivered both in-person and by the internet (ICBT), is efficacious, but access for young individuals is limited and it remains unclear how to structure the care pathway to maximize benefit.Methods: To inform a fully powered randomized controlled trial (RCT), a pilot RCT wil
Turkey is an exceedingly prosperous nation in terms of water. The Tigris and Euphrates, two of the most famous and iconic watercourses in the Middle East (and beyond), flow from the Anatolian mountains within Turkey's borders. This gives Ankara enormous power in geopolitical terms, especially towards the Arab countries downstream, which have always grappled with worrying water supply crises. Over
Children and adolescents exposed to traumatic events are at high risk of developing posttraumatic stress disorder (PTSD). With the rare exception of very young children, their PTSD presentations at the symptom level are similar to those of trauma-exposed adults, as are their patterns of psychiatric comorbidity, particularly for adolescents. Untreated, at least a significant proportion will carry o
Since 1988, China's influence in Myanmar, both on a political and financial scale, has been relevant. Following the democratic bend that occurred in former Burma in 2011 and the ensuing opening to global markets, Beijing has partially lost its long-held privileges in the country. In order to maintain a solid geo-economic supremacy in Naypyitaw's internal affairs, since 2006, China has embarked upo
This paper explores how Ukrainian virtual museums of war are embedded in today’s connective environment of humans, codes and algorithms. In particular, I examine the ways virtuality as a mode of memory-making is deployed by the Meta History: Museum of War to shape the mediation and remembering of the full-scale Russian war against Ukraine as it unfolds. Using digital methods and digital ethnograph
The ability to encode, imagine, and remember coherent representations of the world is crucial for everyday life and depends on a brain network involving the hippocampal region. Scene construction tasks, which measure spatial coherence, have been shown to be sensitive to hippocampal integrity in amnesic patients. Hippocampal dysfunction has been implicated in posttraumatic stress disorder (PTSD), a
We define a new class of Gaussian processes on compact metric graphs such as street or river networks. The proposed models, the Whittle–Matérn fields, are defined via a fractional stochastic differential equation on the compact metric graph and are a natural extension of Gaussian fields with Matérn covariance functions on Euclidean domains to the non-Euclidean metric graph setting. Existence of th
Background: Despite continuous improvements in anti-rheumatic pharmacological treatment, people with chronic inflammatory arthritis still report substantial disease impact. Based on the framework for complex interventions, we thus developed INSELMA, a novel nurse-coordinated multidisciplinary self-management intervention for patients with rheumatoid arthritis, psoriatic arthritis or axial spondylo
Gene therapy using adeno-associated viral (AAV) vectors is a promising approach for the treatment of monogenic disorders. Long-term multi-year transgene expression has been demonstrated in animal models and clinical studies. Nevertheless, uncertainties remain concerning the nature of AAV vector persistence and whether there is a potential for genotoxicity. Here, we describe the mechanisms of AAV v
Objective: We tested the potential of circulating galectin-1, interleukin (IL)-1 beta, IL-6, and tumour necrosis factor alpha (TNF alpha) levels at baseline in individuals with knee pain as biomarkers for development of radiographic knee and/or hand osteoarthritis (OA). Design: This study comprised 212 individuals with knee pain from the Halland osteoarthritis cohort (HALLOA). Clinical characteris
Background: Novel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheimer’s disease (AD), and can track amyloid-β (Aβ) and tau pathology. However, because these biomarkers are strongly associated with the emergence of Aβ pathology, it is difficult to determine the contribution of insoluble tau aggregates to the plasma p-tau signal
Background: In accordance with the EULAR recommendations, the Danish Hospital for Rheumatic Diseases have systematically invited patients with rheumatoid arthritis (RA) to cardiovascular (CV) risk assessment since 2011. Patients with high risk are invited to a follow-up screening after one year. To optimize the screening and tailor it to individual needs, information about who accepts vs. declines
Water scarcity poses a major obstacle to sustainable development, and precise discharge prediction plays a vital role in enabling effective water resource management. This study investigated improved prediction techniques for nonstationary time series. The study evaluated the effect of signal processing techniques and blending approaches on the performance of deep learning models for daily dischar
Comprehensive but interpretable assessment of the environmental performance of diets involves choosing a set of appropriate indicators. Current knowledge and data gaps on the origin of dietary foodstuffs restrict use of indicators relying on site-specific information. This Personal View summarises commonly used indicators for assessing the environmental performance of diets, briefly outlines their
In this work, charge photogeneration and recombination processes of PM6:IDIC-4F and PM6:IDIC blend films were investigated by the steady-state and time-resolved spectroscopies, as well as the time-dependent density functional theory calculations. The peaks in absorption and photoluminescence (PL) spectra of IDIC and IDIC-4F solutions were assigned by combining the experiment and the simulation of
The last couple of decades have seen an explosion of novel colloidal drug delivery systems, which have been demonstrated to increase drug efficacy, reduce side-effects, and provide various other advantages for both small-molecule and biomacromolecular drugs. The interactions of delivery systems with biomembranes are increasingly recognized to play a key role for efficient eradication of pathogens
BACKGROUND: The ABC-stroke score is a risk scheme for prediction of stroke or systemic embolism (SE) in atrial fibrillation (AF). This study sought to examine whether the score could be useful in predicting stroke in AF-naïve individuals and risk stratifying for AF screening. METHODS AND RESULTS: The LOOP (Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder to
