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Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potential efficacy biomarker, but the complex mechanisms underlying its regulation are no

The production of prompt charmed mesons D0, D+ and D∗+, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at the centre-of-mass energy per nucleon pair, (Formula presented.) , of 2.76 TeV. The production yields for rapidity |y| < 0.5 are presented as a function of transverse momentum, pT, in the interval 1–36 GeV/c for the centrality class 0–10% and in the interval

Multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 μb−1 of Pb+Pb collisions at sNN = 5.02 TeV with the ATLAS detector at the LHC. These cumulants provide information on the event-by-event fluctuations of harmonic flow coefficients vn and correlated fluctuations between two harmonics vn and vm. For the first time, a non-zero four-particle c

The production of prompt Ds+ mesons was measured for the first time in collisions of heavy nuclei with the ALICE detector at the LHC. The analysis was performed on a data sample of Pb-Pb collisions at a centre-of-mass energy per nucleon pair, (Formula presented.) , of 2.76 TeV in two different centrality classes, namely 0–10% and 20–50%. Ds+ mesons and their antiparticles were reconstructed at mid

Local agency is marked by its structural boundedness including nation state strategies. We investigate the dynamic and mutually constitutive interrelationship between agency and state strategies to better understand and explain change in local development with the examples of four mining towns: Kiruna (Sweden), Zeitz (Germany), Most (Czechia) and Tatabánya (Hungary). They embody processes of indus

The paper follows the development of the tourism industry in a small, traditional mining town in northern Sweden. It highlights local agency in the diversification process, as well as interpath relations between tourism and mining. Drawing on 21 semi-structured interviews, the paper finds that the two seemingly unrelated paths share the need for a variety of local endowments and in so the dominant

Background: Appendicitis is the most common disease requiring acute abdominal surgery in children, yet the pathogenesis of appendicitis is not fully understood. It can be challenging to diagnose appendicitis clinically, especially in young children, leading to high rates of initial misdiagnosis. It is not clear why some children are affected by a complicated disease course while others recover spo

Small- and medium-sized enterprises (SMEs) have inherent characteristics, which require specific solutions for improving the sustainability performance of their operations. The purpose of this paper is to increase the knowledge on barriers and enablers for the adoption of sustainable manufacturing by manufacturing SMEs and to provide insights into what enablers can be used to overcome existing bar

Insufficient nursing care is a major threat to a patient’s safety. Despite the development of evidence-based guidelines (EBGs) guiding the delivery of high-quality and effective nursing care, research presents an inadequate implementation of EBGs in clinical practice. Patients who appear to receive insufficient nursing care are older patients (≥65 years) with community-acquired pneumonia (CAP), a

We present a study of the optical properties of various steps in the process of fabricating micro light-emitting diodes (μ-LEDs) based on quantum wells embedded in micron-sized InGaN platelets. In this study, we focus on structures for red emission, but the technology is equally suitable for the less technologically challenging blue and green emitting μ-LEDs. The starting point is growth of an InG

The interface between wurtzite and zinc blende InP has been identified as type-II, where electrons gather on the zinc blende side and holes on the wurtzite side of the interface. The photoluminescence resulting from recombination across the interface is expected to be long-lived and to exhibit non-exponential decay of emission intensity after pulsed excitation. We verify this prediction using time