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Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing t

Cadmium-induced bone effect is not mediated via low serum 1,25-dihydroxy vitamin D

Cadmium is a widespread environmental pollutant, which is associated with increased risk of osteoporosis. It has been proposed that cadmium's toxic effect on bone is exerted via impaired activation of vitamin D, secondary to the kidney effects. To test this, we assessed the association of cadmium-induced bone and kidney effects with serum 1,25-dihydroxyvitamin D (1,25(OH)(2)D); measured by enzyme

Noninvasive measurement of diameter changes in the distal abdominal aorta in man

An ultrasound phase-locked, echo-tracking system was used to determine the dynamic properties of the distal abdominal aorta in 10 Caucasian male subjects (mean age, 25 years). Recordings were made at rest and during the blood pressure increase resulting from isometric exercise. The pressure diameter curve was nonlinear with an inflection at about 90-110 mmHg. Above this pressure range, the vessel

Socioeconomic differences in fat intake in a middle-aged population: report from the Malmö Diet and Cancer Study

Background: The objective was to investigate whether socioeconomic differences in fat intake may explain socioeconomic differences in cardiovascular diseases. Methods: The Malm Diet and Cancer Study is a prospective cohort study. The baseline examinations used in the present cross-sectional study were undertaken in 19921994. Dietary habits were assessed using a modified diet history method consist

Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?

Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind complement clown-regulatory proteins, C4b-binding protein (C4BP) and factor H (M), to evade killing by human complement. In addition, sialylation of

Solar mean magnetic field variability: A wavelet approach to Wilcox Solar Observatory and SOHO/Michelson Doppler Imager observations

Solar mean magnetic field (SMMF) measurements from the Wilcox Solar Observatory and with the SOHO/MDI instrument are described and analyzed. Even though two completely different methods of observation are used, the two data sets obtained show a strong similarity. Using continuous wavelet transforms, SMMF variability is found at a number of temporal scales. Detected SMMF signals with a 1–2 year per

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development

Although a number of cytokines have been demonstrated to be critical regulators of development of multiple blood cell lineages, it remains disputed to what degree they act through instructive or permissive mechanisms. Signaling through the FMS-like tyrosine kinase 3 (FLT3) receptor and the hematopoietin IL-7 receptor alpha (IL-7Ralpha) have been demonstrated to be of critical importance for sustai

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

Mast cells are strategically localized along the microvasculature in tissues in close contact with the external environment, such as the skin, lung and intestines. By releasing a multi-faceted spectrum of proinflammatory mediators, such as cytokines and chemokines, mast cells have the capacity to coordinate trafficking of leukocytes. Mast cells play a pathophysiological role in numerous inflammato

Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer

The mitochondrial protein frataxin plays a central role in mitochondrial iron homeostasis, and frataxin deficiency is responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1 in 40000 children. Here we present a single-particle reconstruction from cryoelectron microscopic images of iron-loaded 24-subunit oligomeric frataxin particles at 13 and 17 angstrom resolutio

Isolation of hemicelluloses from barley husks

In this work, arabinoxylan, the primary hemicellulose in barley husks, was isolated from barley husks by steam explosion and ultrafiltration. Ultrafiltration and diafiltration were used to concentrate and to increase the purity of the product which was intended for use as an oxygen barrier film in food packaging. A composite fluoropolymer membrane with a nominal molecular mass cut-off of 10,000 g/

Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants.

Poor survival and differentiation of grafted dopamine neurons limits the application of clinical transplantation in Parkinson’s disease. The survival of grafted dopamine neurons is only improved by a factor of 2–3 by adding neuroprotectants during tissue preparation. We used dye exclusion cell viability and electron microscopy to investigate the effects of the caspase inhibitor ac-YVAD-cmk and the

Small-scale magnetic fields on late-type M-dwarfs

We performed kinematic studies of the evolution of small-scale magneticfields in the surface layers of M-dwarfs. We solved the inductionequation for a prescribed velocity field, magnetic Reynolds number ReM,and boundary conditions in a Cartesian box, representing a volumecomprising the optically thin stellar atmosphere and the uppermost partof the optically thick convective envelope. The velocity

An MC-SS platform for short-range communications in the Personal Network context

Wireless Personal Area Networks (WPAN) has gained interest in the last few years and several air interfaces have been proposed to cover WPAN applications. A Multi-Carrier Spread Spectrum (MC-SS) air interface specified to achieve 130 Mbps in typical WPAN channels, is presented in this paper. It operates in the 5.2 GHz ISM band and achieves a spectral efficiency of 3.25 b.s-1.Hz-1. Besides the robu

Theory based policy evaluation of 20 energy efficiency instruments

Realizing a 20% energy efficiency improvement in Europe by 2020 requires the introduction of good new energy efficiency policies as well as strengthening and enforcing the existing policies. This raises the question: what characterizes good and effective energy efficiency policies and their implementation? Systematic ex post evaluation of energy efficiency policies can reveal factors determining n

Removal of Nickel onto Alkali Treated Rice Bran

Different bases were used for the pretreatment of Rice bran biomass. Pretreatment with bases such as NaOH, Ca(OH)(2) and Al(OH)(3) were found to improve biosorption capacity. But in Rice bran, treatment with 0.5 M NaOH increased its nickel selective adsorption ability very much. The main binding site of nickel in NaOH treated cells is assumed to be carboxylic, hydroxyl, sulphate, phosphate and ami