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Simultaneous 3D T1 and B1+ mapping at 7T using MPRAGE with multiple volumes and driven equilibrium (DE)

MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t

Isotropic T1-mapping of the whole brain by MP-RAGE at different inversion times

Fitting the inversion recovery (IR) at multiple TI provides T1 estimates of high accuracy if performed in a single slice with full relaxation. We present anisotropic 3D variant based on MP-RAGE, where a T1-weighted driven equilibrium is prepared prior to inversion by a second RAGE readout. This abolishes the need for long recovery times and provides volumes of similar contrast for co-registration.

Investigating Political and Technological Contexts in Crisis Communication : China and Beyond

This study aims to theoretically advance the current context-oriented tradition in crisis communication by highlighting the political and technological contexts to understand organizational crises. Using China as a case, this study proposes a broader research agenda that expands the focus from individual, organizational, and cultural domains to political and technological domains for investigating

A simple approach to control rms(B1) by pulse length in variable flip angle (VFA) T1 mapping of human brain

Controlling the saturation of bound magnetization in variable flip angle (VFA) experiments improves the derived parameter maps. Instead of using special CSMT RF pulses, we kept the rmsB1 constant simply by increasing the RF pulse duration with the square of the flip angle. At 3T, VFA T1 mapping of human brain thus showed better compliance to the Ernst equation than at constant pulse duration or B1

Measuring inhomogeneous MT (ihMT) in human brain by multi-parameter mapping (MPM)

Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is sensitive to myelination. Quantification of ihMT in terms of MT saturation (MTsat), the percent reduction of Mz, corrects for underlying T1 and B1+ and allows comparing different implementations to optimize multi-parameter mapping (MPM) protocols. ihMTsat in white matter is

From in situ to ex vivo: the effect of autolysis and fixation on quantitative MRI markers for myelin

Ex vivo histology remains the gold standard against which MRI biophysical models, e.g. the MR g-ratio which characterises the fraction of a fibre’s diameter that is myelinated, are evaluated. The MR g-ratio model requires a measure of myelin density, for which magnetization transfer saturation (MT) has been used as a biomarker. However, changes occurring post mortem, e.g. autolysis, temperature ch

Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities

Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. FLT3 mutations emerged as one of the most common mutations in AML which represent around 35% of all AML

“Crazy Jack” and the “Gay CEO” : Visions, Entrepreneurship, and the Chinese State in the New Digital Economy

This article analyses the visions, careers, and companies of Jack Ma of Alibaba and Geng Le of Blue City. Jack Ma is a well-known business leader and visionary, whereas the less well-known Geng Le only began to receive more attention since launching a successful gay dating app in 2012. The article focuses on the personal narratives and visions of these two IT entrepreneurs. It provides new perspec

Of Visions and Visionaries : Information and Communication Technologies (ICT) in China

This special issue approaches information and communication technologies (ICT) visions and their realisation/implementation at various levels, among different actors and from var- ious perspectives. Conceptually, we distinguish three different dimensions, even though those overlap in the individual contributions as well as in empirical reality – namely ideation- al, instrumental, and relational. T

Rash during lamotrigine treatment is not always drug hypersensitivity a retrospective cohort study among children and adults

Purpose Cutaneous adverse drug reactions (cADRs) are a major cause of lamotrigine (LTG) discontinuation. Remarkable variation in their reported incidence suggests confounders and diverse terms and definitions. The aim of this study was to identify immunological cADRs and to throw light on classification and differential diagnoses in children and adults. Methods Hospital records of 2683 patients wi

Visualization of the Invisible (Editorial)

Visualizing geographical phenomena often involve communication of information and relationships through a map in either 2D or 3D. In many cases, the information conveyed through the map is a simplified and symbolic depiction of phenomena that is visible in our physical environment. However, maps are also effective for the communication of geographical phenomena that are hidden or are by nature “in

Get Rich or Fail Your Exam Tryin': Gender, Socioeconomic Status and Spillover Effects of Blended Learning

We evaluate a natural experiment at a Swedish university, in which students were randomized to either taking all their courses online, or to have some courses online and some on campus (blended learning). Our setting creates two groups for the online courses: One group with no access to campus whatsoever, and one group treated with campus classes in parallel, but unrelated, courses. We show that c

Lung Microenvironments Influence on Mast Cell Plasticity and Spatial Distribution of Immune cells

Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is

Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis

Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, we evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis. Of the drugs tested, decitabine was the most effectiv

The forgotten sub-regional COVID-19 response layer2021 : The case of the WHO Eastern Mediterranean Region

The response to the COVID-19 pandemic have been driven by epidemiology, health system characteristics and control measures in form of social/physical distancing. Guidance, information and best practices have been characterized by territorial thinking with concentration on national health system and social contexts. Information was to a large extent provided from global entities such as the World H