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Value of a QALY and VSI Estimated with the Chained Approach
The value of a Quality-Adjusted Life-Year (QALY) and the Value of a Statistical Injury (VSI) are important measures within health economics and transport economics. Several studies have therefore estimated people’s WTP for these estimates, but most results show problems with scale insensitivity. The Chained Approach (CA) is a method developed to reduce this problem. The objective of this study was
Strategic Decisions : Behavioral Differences Between CEOs and Others
Differences in strategic decision making between CEOs and other people are interesting since CEOs make important economic decisions and impact values and norms in society. Our study combines a large stratified random sample of 199 CEOs of medium-size firms with a carefully selected control group of 200 comparable people. All subjects participated in three different incentivized strategic games — P
Test–retest reliability of Antonovsky’s 13-item sense of coherence scale in patients with hand-related disorders
Purpose: To report on the distribution and test-retest reliability of Antonovsky’s 13-item Sense of Coherence (SOC-13) Scale in patients with hand-related disorders (HRD). Links between the SOC-13 score and factors such as age, number of days between date of injury and start of rehabilitation, gender and educational level were explored. Method: Survey with test–retest, using self-administered ques
Compressive sensing methods for radar cross section ISAR measurements
The compressive sensing algorithm BPDN applied to RCS ISAR measurements is investigated in this paper. It is used to acquire ISAR images from data sets that are incomplete if conventional back projection is used to process images. The aim of the study is to determine if the algorithm can be used to extract accurate RCS values for parts of the measured objects when there are azimuth angle gaps in t
Cancer Specific Mortality in Men Diagnosed with Prostate Cancer before Age 50 Years : A Nationwide Population Based Study
Purpose We compared clinical characteristics and cancer specific mortality in men diagnosed with prostate cancer before vs after age 50 years. Materials and Methods A total of 919 men 35 to 49 years old and 45,098 men 50 to 66 years old who were diagnosed with prostate cancer between 1998 and 2012 were identified in PCBaSe (Prostate Cancer data Base Sweden). Cancer specific mortality was compared
Congenital thumb anomalies and the consequences for daily life : patients’ long-term experience after corrective surgery. A qualitative study
Purpose: The aim of the study was to explore patients’ long-term experience of a congenital hand problem, and the consequences for daily life. Method: Fifteen participants with a median age 24 years (17–55 years), born with thumb hypoplasia/aplasia or thumb duplication were interviewed using a semi-structured interview guide. The interviews were subjected to qualitative content analysis. Results:
Adhesion G protein-coupled receptor G1 (ADGRG1/GPR56) and pancreatic β-cell function
Context: Adhesion G protein-coupled receptor (GPCR)-G1 (ADGRG1) is the most abundant GPCR in human pancreatic islets, but its role in islet function is unclear. Objective: Investigate how ADGRG1 expression and activation by its ligand, collagen III, impacts β-cell function in normal and type 2 diabetic (T2D) islets. Design: Genes associated with the ADGRG1 in human islets was probed by RNA-sequenc
Urbanisering och ekonomisk utveckling : En översikt över debatten och forskningsmiljöer i Sverige
Cohort patterns in Rana tadpole metamorphosis
This study explores the cohort patterns in a size versus time plot of individual metamorphs of Rana tadpoles. This meta-study was based on a number of studies where any of three species of Rana tadpoles were raised in tanks under various treatments (variation in source pond, tadpole density, drying regime, hatching date, food level and competitors). A frequent pattern was found where there was an
Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : A cross-sectional study from the Big Data Sjögren Project Consortium
Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included
A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder represented by the accumulation of intracellular tau protein and extracellular deposits of amyloid-β (Aβ) in the brain. The gene sortilin 1 (SORT1) has previously been associated with cardiovascular disease in gene association studies. It has also been proposed to be involved in AD pathogenesis through facilitating Aβ clearance by binding ap
A mid-Holocene annually laminated sediment sequence from Lake Woserin : The role of climate and environmental change for cultural development during the Neolithic in Northern Germany
Annually laminated sediments of Lake Woserin in north-eastern Germany are investigated using sedimentological and palynological methods. They facilitate high-resolution reconstruction of environmental and land-use change during ca. 7000–4000 cal. BP. Between 6100 and 5800 cal. BP, changes in woodland composition and structure are evident which coincide with a change in subsistence strategy, that i
Path development in different regional innovation systems : A conceptual analysis
Wind-wave interaction effects on offshore wind energy
This thesis is devoted to the investigation of the impacts of fast moving ocean surface waves on the aerodynamics of offshore wind turbines. The impacts of non-locally generated waves (swell) on the Marine Atmospheric BoundaryLayer (MABL) and thereby on offshore wind turbine aerodynamics are studied numerically by using Large Eddy Simulations and the Actuator Line Method.The MABL is often interact
A randomized comparison between league tables and funnel plots as an aid to health care decision-making
Objective Comparison of provider performance is commonly used to inform health care decision-making. Little attention has been paid to how data presentations influence decisions. This study analyzes differences in suggested actions by decision-makers informed by league tables or funnel plots.Design Decision-makers were invited to a survey and randomized to compare hospital performance using either
Variability in the sensitivity among model simulations of permafrost and carbon dynamics in the permafrost region between 1960 and 2009
A significant portion of the large amount of carbon (C) currently stored in soils of the permafrost region in the Northern Hemisphere has the potential to be emitted as the greenhouse gases CO2 and CH4 under a warmer climate. In this study we evaluated the variability in the sensitivity of permafrost and C in recent decades among land surface model simulations over the permafrost region between 19
Skeletal muscle wasting and renewal : a pivotal role of myokine IL-6
Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-renew by means of a controlled process of activation and proliferation of tissue-resident stem cells named satellite cells. Many growth factors, cytokines and myokines produced by skeletal muscle cells play critical roles in local regulation of the inflammatory process and skeletal muscle regeneration durin
Low-temperature growth of boron carbide coatings by direct current magnetron sputtering and high-power impulse magnetron sputtering
B4C coatings for 10B-based neutron detector applications were deposited using high-power impulse magnetron sputtering (HiPIMS) and direct current magnetron sputtering (DCMS) processes. The coatings were deposited on Si(001) as well as on flat and macrostructured (grooved) Al blades in an industrial coating unit using B4C compound targets in Ar. The HiPIMS and DCMS processes were conducted at subst
T50 D.2 Daylighting and lighting retrofit to reduce energy use in non-residential buildings: A literature review
This report presents a literature review about energy-efficient retrofit of electric lighting and daylighting systems in buildings. The review, which covers around 160 research articles, discusses the following energy retrofit strategies: replacement of lamp, ballast or luminaire; use of task-ambient lighting design; improvement in maintenance; reduction of maintained illuminance levels; improveme