Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer’s disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques and tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of AD pathology in living humans. We found 127 differentially abundant proteins (DAPs) across the AD spe

The entitlement to access assistive technology (AT) is fundamental for all individuals. However, challenges encountered during societal crises can significantly impact opportunities for participation and engagement among AT users. Understanding the implications of crises and disasters on AT provision along with their repercussions for end users is crucial. This research endeavors to investigate thThe entitlement to access assistive technology (AT) is fundamental for all individuals. However, challenges encountered during societal crises can significantly impact opportunities for participation and engagement among AT users. Understanding the implications of crises and disasters on AT provision along with their repercussions for end users is crucial. This research endeavors to investigate th

This paper presents the results of an interdisciplinary study encompassing data collected from 108 in-depth interviews and 15 participatory workshops aimed at exploring the requirements of a diverse range of stakeholders in relation to assistive augmentative technologies. The study involved 39 poststroke patients with hand paresis, 39 individuals with spinal cord injuries affecting upper limb funcThis paper presents the results of an interdisciplinary study encompassing data collected from 108 in-depth interviews and 15 participatory workshops aimed at exploring the requirements of a diverse range of stakeholders in relation to assistive augmentative technologies. The study involved 39 poststroke patients with hand paresis, 39 individuals with spinal cord injuries affecting upper limb func

The importance of genetic diversity has been recognised by the Convention on Biological Diversity but attempts at monitoring or improving the genetic diversity of populations have been minimal. Here, we investigate changes over time in the genetic diversity of a wild insect species, Maniola jurtina (Lepidoptera: Nymphalidae) and present a large-scale investigation into contemporary spatial genetic

Background: Despite the rapid pace of assistive robotics development, adoption of these has been limited. This raises questions such as: What contributes to this low uptake? What strategies could be employed to increase uptake? What guidance can be found in the literature to inform alternative approaches or directions for development?Objective: This critical narrative review sheds light on the devBackground: Despite the rapid pace of assistive robotics development, adoption of these has been limited. This raises questions such as: What contributes to this low uptake? What strategies could be employed to increase uptake? What guidance can be found in the literature to inform alternative approaches or directions for development?Objective: This critical narrative review sheds light on the de-

This study seeks to explore the pragmaticalization process of (it's) no biggie, through a corpus-based taxonomical and statistical examination. The research study involves (i) elaborating a taxonomy of no biggie constructions by exploring the variability of the pragmatic functions and the syntactic features associated with the construction; (ii) monitoring the links between the taxonomical types o

The concept of a customer order decoupling point (CODP) has been discussed since 1984. The CODP refers to the point in the supply chain at which a product is linked to a specific customer. Consequently, make to stock (MTS), assemble to order (ATO), make to order (MTO), purchase and make to order (PMTO), andengineer to order (ETO) all refer to different positions of the CODP. The CODP separates the

Among adolescents, loneliness is common. One kind of loneliness, existential loneliness, is understood as a painful part of the human condition. During adolescence, existential loneliness has been shown to be challenging to navigate independently. Therefore, this study aimed to explore Swedish adolescents’ experiences of existential loneliness regarding receiving and providing support. This study

Introduction: Widening participation in education by including students from underrepresented groups has been recognized as important for the last decade. During the recent pandemic, the interest in how to make students from different backgrounds feel part of the university, and connected to their studies and peers, has become an even more widespread concern and therefore important to explore furt

Quality requirements are critical for successful software engineering, with maintainability being a key internal quality. Despite significant attention in software metrics research, maintainability has attracted surprisingly little focus in the Requirements Engineering (RE) community. This position paper proposes a synergistic approach, combining code-oriented research with RE expertise, to create

As one of the most critical components of the vanadium redox flow battery (VRFB), the ion exchange membrane directly influences the battery efficiency and cycle life. Herein, poly(isatin triphenyl) (PIT) containing a lactam structure and devoid of ether bonds is synthesized from isatin and p-terphenyl under superacid catalysis. To achieve the ion transport and investigate the impact of side chain

Now extinct, the aurochs (Bos primigenius) was a keystone species in prehistoric Eurasian and North African ecosystems, and the progenitor of cattle (Bos taurus), domesticates that have provided people with food and labour for millennia1. Here we analysed 38 ancient genomes and found 4 distinct population ancestries in the aurochs—European, Southwest Asian, North Asian and South Asian—each of whicNow extinct, the aurochs (Bos primigenius) was a keystone species in prehistoric Eurasian and North African ecosystems, and the progenitor of cattle (Bos taurus), domesticates that have provided people with food and labour for millennia1. Here we analysed 38 ancient genomes and found 4 distinct population ancestries in the aurochs—European, Southwest Asian, North Asian and South Asian—each of whic

With the development of new radiopharmaceutical therapies, quantitative SPECT/CT has progressively emerged as a crucial tool for dosimetry. One major obstacle of SPECT is its poor resolution, which results in blurring of the activity distribution. Especially for small objects, this so-called partial-volume effect limits the accuracy of activity quantification. Numerous methods for partial-volume c

Efter cirka 20 år med Århuskonventionen har tillämpningen av konventionen haft tid att utvecklas. Införlivandet av konventionen i svensk rätt var från början en komplex uppgift då det inte bara handlar om konventionen i sig själv utan också hur den kan integreras med grundlag, miljöbalk och speciallagar. Till denna komplexitet kommer utvecklingen av riktlinjer på myndigheter och praxis i domstolar

In this paper we provide an analytical solution to an H2 optimal control problem, that applies whenever the process corresponds to a uniformly damped network of masses and springs. The solution covers both stable and unstable systems, and illustrates analytically how damping affects the levels of achievable performance. Furthermore, the resulting optimal controllers can be synthesised using passiv

The aerobic oxidation of carbon monoxide to carbon dioxide is catalysed by the Mo/Cu-containing CO-dehydrogenase enzyme in the soil bacterium Oligotropha carboxidovorans, enabling the organism to grow on the small gas molecule as carbon and energy source. It was shown experimentally that silver can be substituted for copper in the active site of Mo/Cu CODH to yield a functional enzyme. In this stu

Grounded in the social cognitive theory, the main aim of this study is to explore the impact of telepresence, social presence, and emotional engagement on impulsive buying tendencies within the realm of travel live-streaming (TLS). To examine further, the moderating effect of guidance shopping was included. An online questionnaire was distributed to 332 live-streaming viewers from China, and the c

This study aims to investigate the different behaviors with respect to safety measures related to the interaction of e-scooters and bikes with cars in mixed traffic. E-scooters are relatively new vulnerable road users, and their behavior is still not fully understood. For this purpose, an observational study was carried out at an unsignalized at-grade intersection in the city of Catania, Italy. A