Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation

The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinicaThe complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinica

Comparing lexical transfer in second- and third language early vocabulary acquisition The present study compared 30 functional English monolinguals and 30 highly proficient (CEFR C1+) Swedish–English bilinguals. They acquired vocabulary in a pseudo-language derived from typologically unrelated Finnish. None of the participants had productive proficiency in Finnish although for societal reasons the

GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics (turnover of plasma/serum ARGS-aggrecan neoepitope fragments [ARGS]) of GLPG1972 in 3 randomized, double-blind, placebo-controlled phase 1 trials. Study A, a

Introduction: Dual mobility cups (DMC) are gaining in popularity, as a method to reduce the risk of dislocation after fracture-related hip arthroplasty. Our aim was to compare revision rate in general, as well as due to dislocation and infection, after DMC and conventional THA due to femoral neck fracture, for each of the two groups of lateral and posterior approach. Materials and Methods: This ob

Lifetimes of low-lying excited states in the νi13/2+ bands of the neutron-deficient osmium isotopes 169,171,173Os have been measured for the first time using the recoil-distance Doppler shift and recoil-isomer tagging techniques. An unusually low value is observed for the ratio B(E2;21/2+→17/2+)/B(E2;17/2+→13/2+) in 169Os, similar to the “anomalously” low values of the ratio B(E2;41+→21+)/B(E2;21+

Background: Regenerex® is a porous titanium construct with a 3D interconnecting pore structure and biomechanical characteristics close to that of normal trabecular bone. This study aimed to compare the Regenerex (VR) to the non-interconnecting pore structure Porous Plasma Spray (VP) on tibial implants for total knee arthroplasty (TKA) at 5 years. Methods: We enrolled and randomized 61 patients (me

The roughly 600 km long Central Cordillera of Colombia shows a varied tectonic, magmatic, and exhumation history, despite the reasonably homogenous appearance concerning topography, outcropping lithologies, and strike. Here we show with new geo-thermochronological data the thermal evolution of the southern Central Cordillera since the Early Jurassic. Extensive Jurassic magmatism is recorded by U–P

The new cis-dioxomolybdenum (VI) complexes [MoO2(L2)(H2O)] (2) and [MoO2(L3)(H2O)] (3) containing the tridentate hydrazone-based ligands (H2L2 = N'-(3,5-di-tert-butyl-2-hydroxybenzylidene)-4-methylbenzohydrazide and H2L3 = N'-(2-hydroxybenzylidene)-2-(hydroxyimino)propanehydrazide) have been synthesized and characterized via IR, 1H and 13C NMR spectroscopy, mass spectrometry, and single crystal X-

The demand for agricultural products is expected to increase as a result of population growth, changed diets and demands for bioenergy. At the same time, agricultural yields in many regions are expected to be negatively impacted by climate change. Here we show, how altered winter conditions in combination with an extreme weather event impact reproductive development and yield of oilseed rape (Bras

Män som slår kvinnor är i regel återfallsbrottslingar, skriver forskaren Ardavan Khoshnood. Eftersom brotten begås i stundens hetta är straffens längd sällan avskräckande.Men who beat women are usually recidivists, writes researcher Ardavan Khoshnood. Because the crimes are committed in the heat of the moment, the length of the sentence is seldom dissuasive.

The structural transformation of retail is challenging for many small cities. Rather than seeing the retailer as a sole player, this article considers retail in small cities to be shaped in a retail eco system consisting of many different actors besides retailers such as municipalities, landlords, business/city organisations, customers/citizens. The key contribution of the article is to provide ne

최근 노인의 재가서비스 이용 권리 확대 소식에 더하여 스웨덴 노인 주거복지서비스의 현황과 문제점, 그리고 이에 따른 정부의 대응 방안 등을 살펴본다. 최근 조사에 따르면 스웨덴 노인재가복지시스템은 인력 수급의 안정성과 전문성 부족, 인력 공급 부족, 지자체 간의 서비스 질 간극 확대, 재가서비스 이후 시설 서비스로의 이행 지체 등의 어려움을 안고 있다. 스웨덴 정부는 이와 같은 문제를 해결하기 위해 서비스 공급 인력을 양적으로 확대할 뿐 아니라 서비스 이행의 질을 개선하기 위해 집중하고 있다.