Importance: The lack of an in vivo measure for α-synuclein (α-syn) pathology until recently has limited thorough characterization of its brain atrophy pattern, especially during early disease stages. Objective: To assess the association of state-of-the-art cerebrospinal fluid (CSF) seed amplification assays (SAA) α-syn positivity (SAA α-syn+) with magnetic resonance imaging (MRI) structural measur

This article is concerned with the historical evolution of the mining industry in Canada since 1859. The focus is directed on changes that occurred in the industry and allows for the identification of four distinct mining regimes. These regimes are defined using the Regulation Theory, which connects conditions of production, technical progress, financial structures, and social relations. The ident

Between 1980 and 2000, total employment in the Canadian mining sector halved. While the literature on resource economy is thriving in Canada, little is known about how local labor markets experienced such a decline. This article presents a novel strategy to measure the effects of mine closures on local direct, indirect, and induced employment. This ripple effect is estimated using impulse response

Aims and background: Whole-genome sequencing (WGS) is increasingly applied in clinical practice and expected to replace standard-of-care (SoC) genetic diagnostics in hematological malignancies. This study aims to assess and compare the fully burdened cost (‘micro-costing’) per patient for Swedish laboratories using WGS and SoC, respectively, in pediatric and adult patients with acute lymphoblastic

In this study, we simulate the automatic control of an electric wheelchair for indoor Pac-Man-style navigation using solely thought commands. We delve into the decision-making mechanisms of an operational EEG-based brain computer interface that employs a visual oddball paradigm. We investigate strategies to enhance the efficiency of decision-making processes, aiming to accelerate response times wh

Clinical reasoning and decision-making in prehospital contexts are complex, and patient assessments may be influenced by stress or biases, thus potentially risking patient safety. Previous research has shown mixed results regarding cognitive interventions designed to counteract biases and improve decision-making. In educational settings, there are no tools that assess clinical reasoning while also

Background and Objectives: Animal studies have suggested a link between benzodiazepine and related Z-drug (BZDR) use and immune dysfunction. Corresponding evidence in humans is limited and focuses mainly on pneumonia. This study aimed to assess the association of incident BZDR use with subsequent development of serious infections. Methods: This Swedish register-based study included a population-ba

The Sjuøyane archipelago is the northernmost land area of Svalbard; thus, it provides a window to study the terrestrial glacial history and dynamics of the Svalbard–Barents Sea Ice Sheet and complement marine geological studies in the region. To reconstruct the glacial history of Sjuøyane, we describe coastal sedimentary sections in Quaternary sediments and constrain their chronology by radiocarbo

Osteonecrosis (ON) is a common complication of glucocorticoid-based Hodgkin lymphoma (HL) treatment, but the natural evolution and prognosis of ON lesions remain poorly understood. We describe the radiological evolution of ON lesions identified in a Nordic population-based cohort of paediatric HL patients. Magnetic resonance images of suspected ON lesions were centrally reviewed to confirm ON diag

A parent’s life threating illness and death can significantly affect their children's wellbeing in both the short and long term. Support from professionals is recommended when parents lack the ability to help children cope with loss, bereavement, and grief. The overall aim of this dissertation was to illuminate professionals’ encounters with children of a seriously ill or deceased parent and to ex

This qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environ-ment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theoryand the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizationalcommunication web. The results indicated that thisThis qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theory and the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizational communication web. The results indicated that thi

Objective: The scientific literature reports on how social media potentially influences eating disorders, although there is a large gap in the specific case of TikToks influence of adolescent's recovery from anorexia nervosa (AN). Our study uses in-depth interviews with female adolescents primarily suffering from AN to explore how they perceive the social media platform TikTok in relation to their

The field of biological psychiatry faces a growing influx of digital biomarkers spanning self-report, social, behavioral, cognitive, and physiological indicators of various mental health conditions. However, the definition of “digital biomarker,” particularly the “bio-” component, remains unclear. This article reviews the terminology of digital biomarkers in psychiatry and argues for the reservati

Popular Abstract in Swedish Synd och skam. Ogifta mödrar på svensk landsbygd, 1680-1880. Avhandlingens utgångspunkt har varit ogifta mödrar på svensk landsbygd i ett långtidsperspektiv, 1680-1880. Arbetet är kvinnohistoriskt och utgår från en önskan att synliggöra betydelsen av kön i det äldre samhället. Hur tänkte och resonerade man kring kön och sexualitet i det förindustriella bondesamhället? The situation of unmarried mothers in Swedish rural society during 1680–1880 is the subject of this thesis. It focuses on the judicial and religious discourse concerning extra-marital sexuality. The state felt duty-bound to control extra-marital sexuality, and this resulted in a dynamic legislative arena. An important objective has been to study the local consequences of legislative changes and ex

Software engineering practices, including continuous integration, continuous testing, and continuous deployment, aim to streamline and automate the software development process. A cultural and professional movement that builds upon continuous practices, DevOps, seeks to bridge the gap between development and operations. By fostering a collaborative environment, DevOps supports faster, more frequen