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The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (α-Syn) aggregation. Although it is still not entirely clear what precise biophysical processes act as triggers, cumulative evidence points towards a crucial role for protein quality control (PQC) systems in modulating α-Syn aggregation and toxicity. These enc
Venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support for postcardiotomy cardiogenic shock (PCS) in patients undergoing surgery for acute type A aortic dissection (TAAD) is controversial and the available evidence is confined to limited case series. We aimed to evaluate the impact of this salvage therapy in this patient population. Between January 2010 and March 2018, all TAAD patie
Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.
Purpose: In addition to incisional hernia, inguinal hernia is a recognized complication to radical retropubic prostatectomy. To compare the risk of developing inguinal and incisional hernias after open radical prostatectomy compared to robot-assisted laparoscopic prostatectomy. Method: Patients planned for prostatectomy were enrolled in the prospective, controlled LAPPRO trial between September 20
We present and analyze a new approach to improve energy efficiency in cellular IoT devices. The new approach consists of employment of ultra low power wake-up receivers in combination with robust non-coherent modulation. The results show that we can achieve very competitive power consumption, reducing it by up to 50 times, compared to two conventional power saving solutions we use as references. T
A key challenge in X-ray crystallography is to find a good point on the crystal on which to center the beam because the crystal takes radiation damage after a number of shots which significantly distort the measurements. Therefore, the beam needs to be aimed manually by an operator, which results in significant additional effort and time.This paper presents an approach toward automating the beam a
We envision the use of large intelligent surface (LIS) technology, which is a promising concept that goes beyond massive multiple-input multiple-output (MIMO), for positioning applications due to its ability to focus energy in the 3D space. The Cramér-Rao lower bounds (CBLBs) for positioning using a LIS which can resolve amplitude and phase with full resolution have already been determined in the
The case is about grassroots monetary innovations carried out for social purposes. Through the case of the Kenyan community currencies the reader gets an insight into the social challenges these currencies aim to address, the effort that goes into designing these local monies as well as into organising the communities that use them. The reader is presented with the practical challenges faced by th
Hanseatic League of Science (HALOS)Hanseatic League of Science (HALOS) is a unique cross-border ÖKS interreg project with 15 official partner organizations including research institutes in Denmark, Sweden and Germany. Through HALOS the Life Science research and innovation ecosystems will get access to crossborder cooperation platforms where academia and industry can meet. Key stakeholders will be
Connecting the complementary facilities MAX IV & ESS with DESY & European X-FEL creates synergy and a globally unique infrastructure region with fantastic opportunities for innovation and research not least in Life Science. Through Hanseatic League of Science (HALOS) the Life Science research and innovation ecosystems is given a joint platform to take advantage of the facilities and a tool
The increase of plasma levels of high-density lipoproteins and Apolipoprotein A-I (ApoA-I), its main protein component, has been shown to have a positive action on glucose disposal in type 2 diabetic patients. The current study investigates the unexplored function of ApoA-I to prime beta cells for improved insulin secretion. INS-1E rat clonal beta cells as well as isolated murine islets were used
In this paper we analyse the transmission of the electromagnetic field through a dielectric, spherical shell - a simple radome. The source is located inside the shell and consists of a vertical or horizontal electric dipole or a simple array of electric dipoles. A circular PEC (perfect electric conductor) disk is located at the center of the shell and simulates a ground plane. The effect of the sh
Knäleden är kroppens största led och är påtagligt komplicerad. Den utsätts dagligen för stora krafter vid såväl böj och vridrörelser som stötkrafter vid stegisättning. För att den skall fungera optimalt måste flera olika komponenter samverka. Brosket som bekläder benändarna bidrar med stötdämpning och ger en mycket låg friktion vid rörelse. Flera olika ligament och muskler som löper över leden bid
