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Eliciting parents' individual requirements for an inclusive digital school system

Parents often have a busy time sorting out their life puzzles, including getting information about their children's activities in school. More and more communication between teachers and parents take place via digital school systems. It can be hard for parents to find the information they are looking for and the teacher decides when information is sent and what communication method to use. All par

The light-yield response of a NE-213 liquid-scintillator detector measured using 2–6 MeV tagged neutrons

The response of a NE-213 liquid-scintillator detector has been measured using tagged neutrons from 2 to 6 MeV originating from an Am/Be neutron source. The neutron energies were determined using the time-of-flight technique. Pulse-shape discrimination was employed to discern between gamma-rays and neutrons. The behavior of both the fast (35 ns) and the combined fast and slow (475 ns) components of

A systems analysis of biodiesel production from wheat straw using oleaginous yeast : process design, mass and energy balances

Background: Biodiesel is the main liquid biofuel in the EU and is currently mainly produced from vegetable oils. Alternative feedstocks are lignocellulosic materials, which provide several benefits compared with many existing feedstocks. This study examined a technical process and its mass and energy balances to gain a systems perspective of combined biodiesel (FAME) and biogas production from str

Global warming potential and energy analysis of second generation ethanol production from rice straw in India

The environmental sustainability of cellulosic ethanol production from rice straw in India is conducted using life cycle assessment (LCA). Greenhouse gas (GHG) emissions, net energy ratio (NER) and net energy balance (NEB) are studied for ethanol production system using two diverse pretreatment technologies, i.e. dilute acid (DA) and steam explosion (SE) followed by separate hydrolysis and ferment

The test beamline of the European Spallation Source – Instrumentation development and wavelength frame multiplication

The European Spallation Source (ESS), scheduled to start operation in 2020, is aiming to deliver the most intense neutron beams for experimental research of any facility worldwide. Its long pulse time structure implies significant differences for instrumentation compared to other spallation sources which, in contrast, are all providing short neutron pulses. In order to enable the development of me

A new biological recovery approach for PHA using mealworm, Tenebrio molitor

Bacterial polyhydroxyalkanoates (PHA) are expensive partly due to the recovery and purification processes. Thus, many studies have been carried out in order to minimize the cost. Here we report on the use of mealworm, which is the larva of mealworm beetle (Tenebrio molitor) to recover PHA granules from Cupriavidus necator. Mealworms were shown to readily consume the freeze-dried C. necator cells a

From genome-wide arrays to tailor-made biomarker readout – Progress towards routine analysis of skin sensitizing chemicals with GARD

Allergic contact dermatitis (ACD) initiated by chemical sensitizers is an important public health concern. To prevent ACD, it is important to identify chemical allergens to limit the use of such compounds in various products. EU legislations, as well as increased mechanistic knowledge of skin sensitization have promoted development of non-animal based approaches for hazard classification of chemic

The dynamics of platelet activation during the progression of streptococcal sepsis

Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive Streptococcus pyogenes infection at 5,12, and 18 hours post infection and correlated this to parameters of infection. The platelet population in ex-

Assessing the capabilites to manage risks in energy systems–analytical perspectives and frameworks with a starting point in Swedish experiences

In this study we conceptualise how a capability approach could be used for analysing the conditions for preserving security of energy supply. We derive a concept, ‘energy system capability’, to describe how well the system is designed for this purpose. Based on a socio-technical systems perspective, we suggest that this capability is composed of five categories of ‘building blocks’: technical stru

Binding and inhibition of spermidine synthase from Plasmodium falciparum and implications for in vitro inhibitor testing

The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoMet) to putrescine or to spermidine to form spermidine or spermine, respectively. In an effort to understand why efficient inhibitors of PfSpdS have be

The influence of magnetic steps on bulk superconductivity

We study the distribution of bulk superconductivity in presence of an applied magnetic field, supposed to be a step function, modeled by the Ginzburg-Landau theory. Our results are valid for the minimizers of the twodimensional Ginzburg-Landau functional with a large Ginzburg-Landau parameter and with an applied magnetic field of intensity comparable with the Ginzburg-Landau parameter.

Thermal enhancement by using grooves and ribs combined with delta-winglet vortex generator in a solar receiver heat exchanger

A good heat transfer performance with moderate pressure drop penalty, as well as a high mixing effect contributes to the increase of a solar receiver thermal efficiency. In this study, delta-winglet vortex generators (DWVGs), and the combination of DWVGs and obstacles are numerically studied to reveal the effects on a solar receiver heat exchanger and the heat transfer, friction factor and mixing.

Paradoxical role of hmgb1 in pancreatic cancer : Tumor suppressor or tumor promoter?

Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabil

α-Synuclein is a Novel Microtubule Dynamase

α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkab

Manufacturing backshoring : a systematic literature review

The purpose of this research is to review and analyze in a systematic manner the current research published in peer-reviewed international scientific journals on the backshoring of manufacturing. We identify 20 articles published from 2009 to early 2016. We classify and discuss the literature according to publication year, research methodology, industry type, and firm size. Using content analysis,

Variable residence time-based model for BOD removal in free-water surface wetlands

Constructed wetlands have been increasingly used for treatment of secondary wastewater containing various contaminants. This paper presents a Variable Residence Time (VART)-based model, called VART-BOD model, for simulation of BOD removal processes in constructed wetlands with free water surface (FWS). Mathematically, the VART-BOD model describes a free water surface wetland with three vertical la

Update on hereditary colorectal cancer

In the past two decades, significant advances have been made in our understanding of colorectal (CRC) tumors with DNA mismatch (MMR) repair deficiency. The knowledge from molecular and genetic alterations in a variety of clinical conditions has refined the disease terminology and classification. Hereditary non-polyposis colorectal cancer (HNPCC) encompasses a spectrum of conditions that have signi

GaAsP Nanowires Grown by Aerotaxy

We have grown GaAsP nanowires with high optical and structural quality by Aerotaxy, a new continuous gas phase mass production process to grow III-V semiconductor based nanowires. By varying the PH3/AsH3 ratio and growth temperature, size selected GaAs1-xPx nanowires (80 nm diameter) with pure zinc-blende structure and with direct band gap energies ranging from 1.42 to 1.90 eV (at 300 K), (i.e., 0

Long-term oxygen therapy 24 vs 15 h/day and mortality in chronic obstructive pulmonary disease

Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 24 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypo