The amygdala was highlighted as an early site for neurofibrillary tau tangle pathology in Alzheimer's disease in the seminal Braak & Braak article (1991). This knowledge has, however, only received traction recently with advances in imaging and image analysis techniques. Here, we provide a cross-disciplinary overview of pathology and neuroimaging studies on the amygdala. These studies provide

This study investigates and describes the Haemosporidian parasite composition of the host bird community in the Ammarnäs area from 1999 to 2020, along with the effect of avian malaria infection on host body condition, based on a data set comprising body measurements and infection status for the Plasmodium, Haemoproteus, and Leucocytozoon genera in captured birds from five sample years, and also a

Häri beskrivs en metod för sulfonering av EPDM. Detta examensarbete syftade till att tillverka jonledande, elastomera filmer för korrosionshämmande packningsmaterial. För att uppnå jonledning svälldes vulkaniserade prover i 1,2-dikloretan innan sulfonering med trimetylsilyl klorsulfonat som sulfoneringsagent. Förändringar i mekaniska och termiska egenskaper utvärderades, samtidigt som jonledning sHerein a method for sulfonation of EPDM is described. This thesis aimed to prepare ion conducting elastomer films for use as corrosion inhibiting materials. To achieve ion conductivity, vulcanised samples were swelled in 1,2-dichloroethane and sulfonated using trimethylsilyl chlorosulfonate as sulfonating agent. Changes in mechanical, thermal and ion conductive properties were assessed. Sulfonated

All organisms are made up ofcells, the smallest functional unit of life. While organisms such asplants and animalscan consist of trillions of cells, others consist of just one cell.One group of unicellularorganisms is called bacteria. Because oftheir small size, bacteria and other microscopic small organisms are classified as microorganisms. In nature, mostbacteria do not live as single cells. Th

Embryo implantation, a crucial step in human reproduction, is tightly controlled by estrogen and progesterone (P4) via estrogen receptor alpha and progesterone receptor (PGR), respectively. Here, we report that N6-methyladenosine (m6A), the most abundant mRNA modification in eukaryotes, plays an essential role in embryo implantation through the maintenance of P4 signaling. Conditional deletion of

Estimating glomerular filtration rate (GFR) is important in daily practice to assess kidney function and adapting the best clinical care of patients with and without chronic kidney disease. The new creatinine-based European Kidney Function Consortium (EKFC) equation is used to estimate GFR. This equation was developed and validated mainly in European individuals and based on a rescaled creatinine,

Embryo implantation involves a sterile inflammatory reaction that is required for the invasion of the blastocyst into the decidua. Adenosine triphosphate (ATP) released from stressed or injured cells acts as an important signaling molecule to regulate many key physiological events, including sterile inflammation. We found that the amount of ATP in the uterine luminal fluid of mice increased during

During decidualization in rodents, uterine stromal cells undergo extensive reprogramming to differentiate into distinct cell types, forming primary decidual zones (PDZs), secondary decidual zones (SDZs), and layers of undifferentiated stromal cells. The formation of secondary decidual zones is accompanied by extensive angiogenesis. During early pregnancy, besides ovarian estrogen, de novo synthesi

(1) Background: Inflammatory responses are implicated in embryo implantation, decidualization, pregnancy maintenance and labor. Both embryo implantation and decidualization are essential to successful pregnancy in rodents and primates. S100A6 is involved in inflammation, tumor development, apoptosis and calcium homeostasis. S100A6 is strongly expressed in mouse decidua, but the underlying mechanis

Mesial temporal lobe epilepsy (TLE) is a common neurological disorder affecting the hippocampus and surrounding medial temporal lobe (MTL). Although prior studies have analyzed whole-brain network distortions in TLE patients, the functional network architecture of the MTL at the subregion level has not been examined. In this study, we utilized high-resolution 7T T2-weighted magnetic resonance imag

Hippocampal sulcal cavities (HSCs) are frequently observed on MRI, but their etiology and relevance is unclear. HSCs may be anatomical variations, or result from pathology. We assessed the presence of HSCs, and their cross-sectional association with demographics, vascular risk factors and cognitive functioning in two study samples. Within a random sample of 92 patients with vascular disease from t

Purpose – This paper is a study of creating organization in the case of cultural projects; cultural entrepreneurship. This includes taking advantage of opportunities and using ones social capital through networks. It is a case study of Vandalorum which is an Swedish international art and design centre with a strong regional connection. They want to offer close collaborations between artists, desig

This study aimed to investigate various properties associated with human protein deletions, encompassing deletion length and position, amino acid composition, flanking amino acid composition, functions of the host proteins, the functional role of the corresponding gene, relative positioning with protein domains, protein structure within the deletion region, and conservation, to identify potential

Virtual Reality (VR) shooting simulators have gained popularity as effective training and entertainment tools. GAIM is a Swedish company specializing in VR shooting simulators, offering VR headsets with physical dummy guns and rifles. These dummy weapons contain complex electronics that are prone to compilations, especially because the Printed Circuit Board (PCB) is fitted in very compact spaces i

Unitization, that is, the encoding of an association as one integrated entity, has been shown to improve associative memory in populations presenting with associative memory deficit due to hippocampal dysfunction, such as amnesic patients with focal hippocampal lesions and healthy older adults. One reason for this benefit is that encoding of unitized associations would rely on the perirhinal corte

Cerebral perivascular spaces (PVS) are small physiological structures around blood vessels in the brain. MRI visible PVS are associated with ageing and cerebral small vessel disease (SVD). 7 Tesla (7T) MRI improves PVS detection. We investigated the association of age, vascular risk factors, and imaging markers of SVD with PVS counts on 7 T MRI, in 50 persons aged ≥ 40. The average PVS count ± SD

AbstractBackground and objective:Defunctioning loop ileostomy (DLI) is frequently used to decrease the consequences of anastomotic leak after ileal pouch-anal anastomosis (IPAA) surgery but is controversial because of stoma-associated morbidity. The aim of this study was to describe stoma-associated morbidity in IPAA–DLI patients compared with terminal ileostomy patients.Methods:Patients treated w

This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells in

INTRODUCTION: Smaller hippocampal volumes have been associated with major depressive disorder (MDD). The hippocampus consists of several subfields that may be differentially related to MDD. We investigated the association of occurrence of major depressive episodes (MDEs), assessed five times over seven years, with hippocampal subfield and entorhinal cortex volumes at 7 tesla MRI.METHODS: In this p