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Direct-to-consumer (DTC) genetic tests (GT) have provoked criticism over their potential adverse impact on public health. The European Parliament called for a ban on DTC advertising of GT during the debate for the adoption of a European Regulation on in vitro diagnostic medical devices. This proposal, however, was not ultimately retained in the final text. Instead, the regulation includes an artic
The advent and refinement of sequencing technologies has resulted in a decrease in both the cost and time needed to generate data on the entire sequence of the human genome. This has increased the accessibility of using whole-genome sequencing and whole-exome sequencing approaches for analysis in both the research and clinical contexts. The expectation is that more services based on these and othe
While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of i
The increasing implementation of next-generation sequencing technologies in the clinical context and the expanding commercial offer of genetic tests directly-toconsumers has increased the availability of previously inaccessible genetic information. A particular concern in both situations is how the volume of novel information will affect the processing of genetic and genomic information from minor
In socials insects, exploration is fundamental for the discovery of food resources and determines decision-making. We investigated how the interplay between the physical characteristics of the paths leading to food sources and the way it impacts the behaviour of individual ants affects their collective decisions. Colonies of different sizes of Lasius Niger had access to two equal food sources thro
Transnational police readily use martial language in the stories they tell about their work. Their actual work, however, tells a different and less dramatic story. Why, then, do they insist on these warlike tales? Why is there a discrepancy between the self-representation of transnational policing and its reality? Using an ethnographic study, this article provides some answers. First, it includes
Aim: Depression is common and rising in adolescents. Recent meta-analyses indicate a moderate effect of exercise on depression symptoms. Clinically referred adolescents and their experiences of an exercise intervention have rarely been studied. The aim of this study was to describe clinically referred adolescents’ experience of moderate to vigorous exercise as a treatment for depression. Methods:
Aerosol technology is a promising platform to synthesize and study core-shellnanoparticles - a multi-elemental nanoparticle system where the core of one material is covered by a shell of another material. In this thesis, two distinctly separate strategies have been explored to synthesize core-shell nanoparticles by aerosol methods: physical vapor deposition (PVD) by evaporation, and surface segreg
Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. Dendritic cells (DCs) ar
MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t
Fitting the inversion recovery (IR) at multiple TI provides T1 estimates of high accuracy if performed in a single slice with full relaxation. We present anisotropic 3D variant based on MP-RAGE, where a T1-weighted driven equilibrium is prepared prior to inversion by a second RAGE readout. This abolishes the need for long recovery times and provides volumes of similar contrast for co-registration.
This study aims to theoretically advance the current context-oriented tradition in crisis communication by highlighting the political and technological contexts to understand organizational crises. Using China as a case, this study proposes a broader research agenda that expands the focus from individual, organizational, and cultural domains to political and technological domains for investigating
Controlling the saturation of bound magnetization in variable flip angle (VFA) experiments improves the derived parameter maps. Instead of using special CSMT RF pulses, we kept the rmsB1 constant simply by increasing the RF pulse duration with the square of the flip angle. At 3T, VFA T1 mapping of human brain thus showed better compliance to the Ernst equation than at constant pulse duration or B1
Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is sensitive to myelination. Quantification of ihMT in terms of MT saturation (MTsat), the percent reduction of Mz, corrects for underlying T1 and B1+ and allows comparing different implementations to optimize multi-parameter mapping (MPM) protocols. ihMTsat in white matter is
