Several people with Parkinson's disease have been treated with intrastriatal grafts of fetal dopaminergic neurons. Following autopsy, 10-22 years after surgery, some of the grafted neurons contained Lewy bodies similar to those observed in the host brain. Numerous studies have attempted to explain these findings in cell and animal models. In cell culture, α-synuclein has been found to transfer fro

Bolin K, Berggren F, Forsgren L. Lacosamide as treatment of epileptic seizures - cost utility results for Sweden. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01320.x. (c) 2010 The Authors Journal compilation (c) 2010 Blackwell Munksgaard. Objectives - To calculate cost per additional quality-adjusted life-year (QALY) for lacosamide as adjunctive treatment for patients with uncontrolled partia

Kostnaderna för att åtgärda fukt- och vattenskador i våra våtrum har ökat dramatiskt och oroväckande under senare år. I den skadeinventering som ingick i SABOs stora projekt 'Fukt och mögel i flerbostadshus' uppvisade 11,3 procent av våtrummen skador av olika slag

This paper discusses the evolutionary function of certain advanced aspects of cognition, like planning, self-awareness, and free will. The inner environment of an agent consists of all representations which the agent can actively "think about". A distinction is made between immediate planning, where plans are made for present needs, and anticipatory planning, where future needs are predicted. Huma

An HbA1c threshold of ≥42 mmol/mol has been proposed to diagnose prediabetes. The sensitivity, specificity and positive predictive value of the proposed threshold for detection of individuals with prediabetes was examined in a study of 573 randomly selected individuals from Vara and Skövde. In addition, the utility of the FINDRISC questionnaire and of a fasting glucose test in combination with thr

BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury is a pivotal mechanism in critical illness and in the development of multiple organ dysfunction syndrome, in which the nuclear factor kappa B (NF-κB) activation plays a central role. Intestinal I/R injury initiates the extrinsic tissue factor or factor VIIa-dependent pathway of coagulation, also of importance in multiple organ dysfuncti

Electric breakdown in semihomogeneous geometries has been studied in n-hexane and transformer oil using a laser triggering method for fields far below the spontaneous breakdown field. The method uses a laser-produced plasma to initiate the breakdown. Strong self focusing in the liquids was limited by increasing the numerical aperture of the laser beam to > 0.20 prior to focusing. Electrical breakd

Detta föredrag vid en stiftshistorisk dag lyfter fram det enda kända fall där en svensk präst vägrat tvångsdöpa ett baptistbarn som hämtats till dop av länsman. Sådan vägran förekom flera gånger i Danmark. Barnet, som var brorsdotter till baptistpionjären F. O. Nilsson, döptes några dagar senare "på pastors inrådan och moderns begäran", men fallet behandlades ändå i domkapitlet, där Nordblom så sm

Successful tissue engineering with the aid of a polymer scaffold offers the possibility to produce a larger construct and to mould the shape after the defect. We investigated the use of cryogelation to form protein-based scaffolds through different types of formation mechanisms; enzymatic crosslinking, chemical crosslinking, and non-covalent interactions. Casein was found to best suited for enzyma

Consider a reflected random walk Wn+1 = (W-n +X-n)(+), where X-o, X-1,... are i.i.d. with negative mean and subexponential with common distribution F. It is shown that the probability that the maximum within a regenerative cycle with mean mu exceeds x is approximately mu (F) over bar(x) as x --> infinity, and thereby that max (W-o,..., W-n) has the same asymptotics as max(X-o,...,X-n) as n --> inf