Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enz

Background: Comparisons of second-line anti-tumour necrosis factor (TNF) agents and vedolizumab are sparse. Aim: To evaluate the effectiveness of anti-TNF agents compared to vedolizumab as second-line biologics in inflammatory bowel disease (IBD). Methods: A propensity score-matched cohort was created using Swedish nationwide registers. Patients with Crohn's disease or ulcerative colitis, exposed

Lecanoraceae is one of the largest families of the Lecanoromycetes, with about 30 accepted genera, many of which, however, have uncertain status and/or circumscriptions. We assess the phylogenetic position of the genus Bryonora and its segregate Bryodina for the first time, using a six-locus phylogeny comprising the Lecanoraceae as well as closely related families. We find strong support for the p

The subject of the present thesis is children’s rights in the process of debt collection. The main focus of the thesis is article 3.1 of Convention on the Rights of the Child (CRC) and its legal relevance in proportionality tests prior to decisions on seizure and sales of houses and apartments in Swedish insolvency law. The thesis is based on two studies. One legal dogmatic study on Swedish enforc

Background: In Sweden, core treatment for osteoarthritis is offered through a Supported Osteoarthritis Self-Management Programme (SOASP), combining education and exercise to provide patients with coping strategies in self-managing the disease. The aim was to study enablement and empowerment among patients with osteoarthritis in the hip and/or knee participating in a SOASP. An additional aim was to

Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes G

AimsIt is increasingly argued that place branding is an important element in sustainable urban development (e.g. Therkelsen et al., 2021; Taecharungroj et al., 2019). However, there are still unresolved ethical difficulties connected to the relation between sustainable development goals and place branding strategy. For example, a typical ethical dilemma arising at the nexus of sustainable developm

Unisexual bryophytes provide excellent models to study the mechanisms that regulate the frequency of sexual versus asexual reproduction in plants, and their ecological and evolutionary implications. Here, we determined sex expression, phenotypic sex ratio, and individual shoot traits in 242 populations of the cosmopolitan moss Pseudoscleropodium purum spanning its whole distributional range. We te

This chapter focuses on the interface between international and European human rights efforts and on victims in a variety of contexts. It addresses minority rights, inasmuch as they continue to be violated with relative impunity in Europe, and concludes with some overall impressions and a list of issues not dealt with for reasons of space. The Universal Declaration of Human Rights served as an ins

Inom den teoretiska filosofin så finns det ett antal klassiska texter och argument som de flesta förr eller senare kommer i kontakt med. En av dessa texter är den uppsats med titeln Time som John McTaggart Ellis McTaggart fick publicerad 1908. Uppsatsen är ett försök att övertyga läsaren om tidens beskaffenhet, för att senare konstatera att det är självmotsägande att påstå att någonting skulle h

This essay concerns the issue of democracy and judicial review. The main focus is on the justification of both a positive and a negative attitude towards judicial review, and the values these justifications are based on. The analysis is made by textual analysis of four authors with different opinions of the subject matter: Robert Dahl and Jeremy Waldron who has a negative attitude towards judicial

Today we can sometimes discern a tendency in cultural policy in Sweden and abroad, of using culture as a tool to achieve development. In Sweden this tendency is the most obvious at the regional level. In this thesis I study this tendency in the cultural policy in Region Skåne. The aim is firstly to examine in what way the tendency of integrating a development perspective in the cultural policy, i

Populärvetenskaplig sammanfattning: Allt fler rapporter har kommit under de senaste åren som visar på att våg- och stormklimatet har förvärrats sedan 1960-talet. Detta har oroat bland andra återförsäkringsbolag som har betalat ut allt mer pengar till stormrelaterade skador de senaste åren. Andra undersökningar har visat att det nuvarande storm- och vågklimatet inte är värre än det var i början av The effects of a global climatic change on the wind climate of northwestern Europe are investigated with the aid of a regional climate model. There have up to date been few studies of how the wind climate will react to a greenhouse gas warming. Those that have been done are mostly global scale studies and centered on changes in storm activity during the winter season. I’m using data from a regiona

Brandmannayrket kan ses som ett genom historien manlig dominerat yrket. I huvudsak är det än i dag män som innehar yrket, men krav på förändring har börjat ställas. Mitt syfte med denna uppsats är att skapa ny kunskap om och dekonstruera könsmärkta dikotomier och på så sätt synliggöra och problematisera kopplingen mellan könsuppdelning och skapandet av kön. I min studie undersöker jag hur det i en

The essay, which is solely theoretical to its form, presents a critical view upon the unproblematized usage of the concept of ethnicity in the Swedish mass media discourse. Theories of critical discourse analysis and post colonial nature is applied to and used to analyze what ethnicity really means. The essay also provides an insight in the functions and power of mass media in Sweden today to unde

Populärvetenskaplig sammanfattning: Våtmarkers utvecklingshistoria kan rekonstrueras genom att deras lagerföljd undersöks. Genom att studera de sediment, växtdelar och pollen som en våtmark är uppbyggd av kan man dra slutsatser om hur den bildats och hur dess utbredning varierat på grund av klimatförändringar och/eller mänsklig påverkan. Rekonstruktioner av förändringar i våtmarkers utbredning bidWetlands are of uttermost biological importance as they function as natural purifiers, absorb nitrogen, and contribute to the landscape biodiversity. In a long term, the history and change, in area- and volume extent, of wetlands reflect climate trends through time. This master’s thesis is an attempt to develop a methodology that in a simple and robust way reconstructs wetland changes using sedime

Problempresentation: Vietnam drabbas av i genomsnitt 5-6 tyfoner varje år, och dessa kan orsaka stor förödelse och många dödsfall när de passerar in över land. När en tyfon passerar medför det högt vattenstånd, höga vågor, starka vindar och kraftiga regnfall. Om högt vattenstånd sammanfaller med höga vågor orsakar det översköljning samt erosion av strandvallar och sanddyner längs kustlinjen. Detta