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Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

Importance: Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control is a clinically important therapeutic goal of surgical intervention, including nodal surgery. Objective: To determine how frequently SLN biopsy without completion lymph node dissection (CLND) results in long-term regional nodal disease control in patients with SLN metastase

Incidence of Aphasia in Ischemic Stroke

Introduction: A decrease in ischemic stroke (IS) incidence has been observed in high income countries during the last decades. Whether this has influenced the occurrence of aphasia in IS is uncertain. We therefore examined the incidence rate and potentially related determinants of aphasia in IS. Methods: We prospectively examined consecutive patients admitted to hospital with first-ever acute IS b

Diving in : Affect, fieldwork and self-reflexivity

Paper på SIEFs 13:e kongress Ways of Dwelling: Crisis - Craft – Creativity, International Society for Ethnology and Folklore (SIEF), Georg-August Universität, Göttingen 26-30 mars 2017The notion of 'affect' have long been a key concept in the study of fandom, and the term has been used to explicate fandom "affective investments" (Grossberg 1992), "affective play" (Hills 2001) and "affective space" (Lamerichs 2014). The turn, in recent years, to ethnographic study within fandom-studies has led to increasing discussion on researcher/field issues; specifically on self-reflexivity

Effect of sex on survival after resection of oesophageal cancer : nationwide cohort study

BACKGROUND: Accumulating evidence suggests a survival benefit after curative oesophageal cancer surgery in women compared with men. The aim of this study was to explore sex disparities in survival after surgery with curative intent in patients with oesophageal cancer.METHODS: This was a population-based cohort study, including all patients with oesophageal or gastric cancer who underwent surgery w

'The digital cardiologist' : How technology is changing the paradigm of cardiology training

In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor

“It was a good… good, bad situation.” : Cameroonian fathers’ experiences of childbirth in Sweden

Introduction: In Sweden, partner's presence during childbirth is generally recommended. However, cultural values and norms in some immigrant societies can be an obstacle to this. Objective: To examine the experiences of Cameroonian fathers during their women's labour and childbirth in Sweden. Design: An exploratory qualitative study with semi-structured interviews were used for data collection and

A 5.8-GHz Rectifier Using Diode-Connected MESFET for Space Solar Power Satellite System

To improve the power handling capability at ground stations of a 5.8-GHz solar space power satellite using microwave power transmission, a power charge-pump meta-semiconductor field-effect transistor (MESFET)-based rectifier is presented in this article. Unlike conventional microwave Schottky diodes, diode-connected MESFETs, whose nonlinear characteristics help them to have a unique current&#x

Increase in protandry over time in a long-distance migratory bird

Protandry is a widespread life-history phenomenon describing how males precede females at the site or state of reproduction. In migratory birds, protandry has an important influence on individual fitness, the migratory syndrome, and phenological response to climate change. Despite its significance, accurate analyses on the dynamics of protandry using data sets collected at the breeding site, are l

In Situ H2 Reduction of Al2O3-Supported Ni- and Mo-Based Catalysts

Nickel (Ni)-promoted Molybdenum (Mo)-based catalysts are used for hydrotreatment processes in the chemical industry where the catalysts are exposed to high-pressure H2 at elevated temperature. In this environment, the catalyst transforms into the active phase, which involves the reduction of the oxide. Here, we report on the first in situ study on the reduction of alumina supported Ni- and Mo-base

Practical design space exploration

Multi-objective optimization is a crucial matter in computer systems design space exploration because real-world applications often rely on a trade-off between several objectives. Derivatives are usually not available or impractical to compute and the feasibility of an experiment can not always be determined in advance. These problems are particularly difficult when the feasible region is relative

HPVM2FPGA: Enabling True Hardware-Agnostic FPGA Programming

Current FPGA programming tools require extensive hardware-specific manual code tuning to achieve performance, which is intractable for most software application teams. We present HPVM2FPGA, a novel end-to-end compiler and autotuning system that can automatically tune hardware-agnostic programs for FPGAs. HPVM2FPGA uses a hardware-agnostic abstraction of parallelism as an intermediate representatio

Persistent Aspergillus fumigatus infection in cystic fibrosis : impact on lung function and role of treatment of asymptomatic colonization-a registry-based case-control study

BACKGROUND: Aspergillus fumigatus is the most common filamentous fungus isolated from the airways of people with cystic fibrosis (CF). The aim of this study was to investigate how chronic A. fumigatus colonization affects lung function in people with CF, to identify risk factors for colonization, and to evaluate antifungal treatment of asymptomatic Aspergillus colonization.METHODS: Data from 2014-

Genetic regulation of RNA splicing in human pancreatic islets

BackgroundNon-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants influence diabetes susceptibility are unknown.ResultsWe examine splicing QTLs (sQTLs) in pancreatic islets fro

The genetic contribution to hand osteoarthritis

Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including