Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we used bio-orthogonal non-canonical amino acid tagging for global analysis of newly translated proteins in fibro

Bacteriophages encode a wide variety of cell wall disrupting enzymes that aid the viral escape in the final stages of infection. These lytic enzymes have accumulated notable interest due to their potential as novel antibacterials for infection treatment caused by multiple-drug resistant bacteria. Here, the detailed functional and structural characterization of Thermus parvatiensis prophage pe

While consumer engagement and value cocreation research proliferate, it is important to explore these concepts from an ecosystem-based multi-stakeholder perspective as, therefore, undertaken in this article. Specifically, this study marks a pioneering attempt in conceptualizing stakeholder engagement (SE) as a core foundation of stakeholder value cocreation within multi-stakeholder service ecosyst

A significant fraction of an exoplanet transit model evaluation time is spent calculating projected distances between the planet and its host star. This is a relatively fast operation for a circular orbit, but slower for an eccentric one. However, because the planet's position and its time derivatives are constant for any specific point in orbital phase, the projected distance can be calculated ra

This paper presents a systematic investigation of the influence of streamturbulence on the pressure forces on a single tube. Grids were used to producedifferent turbulent flow fields with longitudinal integral scale (eddy size)ranging from 0.1 to 0.5 tube diameters and turbulence intensities ranging from0.1 to 3-2 %. The measurements were carried out at two Reynolds numbers, 2.7 - 10 and U.1-104 ,

We present a detailed analysis of HARPS-N radial velocity observations of K2-100, a young and active star in the Praesepe cluster, which hosts a transiting planet with a period of 1.7 d. We model the activity-induced radial velocity variations of the host star with a multidimensional Gaussian Process framework and detect a planetary signal of 10.6 ± 3.0 m s−1, which matches the transit ephemeris,

Mosses have often been used for biomonitoring because of their diversity of habitats, structural simplicity, and rapid multiplication rate. This research aimed to study the tolerance of heavy metal in 3 species of terricolous mosses i.e., Barbula consanguinea, Hyophila apiculata, and H. involuta. The gametophores of mosses were immersed at 4 concentrations of each of the heavy metals Cd, Pb, and Z

Background: Drug Use Disorder (DUD) is a major contributor to world-wide morbidity and mortality. The extensive national registers in Sweden provide the basis for a study of spatial and temporal patterns of DUD onset and recurrence in Sweden from 2001–2015. Methods: To identify patterns of DUD over space, time and gender for Swedish individuals aged 15–35, space–time clustering using SaTScan was a

Halophilic archaea are polyextremophiles with the ability to withstand fluctuations in salinity, high levels of ultraviolet radiation, and oxidative stress, allowing them to survive in a wide range of environments and making them an excellent model for astrobiological research. Natrinema altunense 4.1R is a halophilic archaeon isolated from the endorheic saline lake systems, Sebkhas, located in ar

Sverige och EU har satt upp ambitiösa mål för att minska utsläppen av växthusgaser. Jordbruket står för en stor del av utsläppen och kraftfulla styrmedel behövs. Samtidigt sker handel med jordbruksprodukter på världsmarknaden, vilket innebär att styrmedel som visserligen minskar utsläppen i Sverige och EU också kan leda till att produktion och utsläpp ökar utanför EU – så kallat utsläppsläckage. H

Jordbruket står för en stor del av de globala utsläppen av växthusgaser och ett globalt klimatavtal skulle minska utsläppen.Ett sådant avtal är emellertid svårt att nå. Vi har undersökt hur utsläppen från jordbruket påverkas av en global klimatskatt i olikautformningar och av en klimatskatt som endast införs i EU. Vi finner att:• En global skatt som är lika hög i alla länder ger en relativt stor u

Nitrifikationshämmare (NI) är ett preparat som kan appliceras i samband med gödselspridning. Syftet är att minska risken för kväveläckage och utsläpp av lustgas från jordbruksmark genom att fördröja kvävets omvandling i marken. Denna studie ger en översikt av forskningsläget för NI. Flera studier visar att NI kan ge stora reduktioner av kväveförluster vid rätt förhållanden.Dock finns kunskapslucko

Background: Tissue factor is the main initiator of blood coagulation, and tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the initiation of blood coagulation. The genetic variation of TFPI and the relation to venous thromboembolism (VTE), that is, venous thrombosis and pulmonary embolism, remains to be clarified. This exome sequencing study aimed to determine the molecular epide

Background: Direct-to-consumer telemedicine (TM), with patients having access to a physician via video or text chat, has gradually been introduced into Swedish primary care during the last two decades. Earlier studies have concluded that patients were generally satisfied with TM and the satisfaction rate was consistently above 80% and comparable with in-person visits. Despite the number of studies

K2-146 is a cool, 0.358M⊙ dwarf that was found to host a mini-Neptune with a 2.67 day period. The planet exhibited strong transit timing variations (TTVs) of greater than 30 minutes, indicative of the presence of an additional object in the system. Here we report the discovery of the previously undetected outer planet in the system, K2-146 c, using additional photometric data. K2-146 c was found t

Quantum control is implemented in a 2-beam fs/ns rotational CARS setup via a second control pulse with variable delay. The potential of the concept for improved diagnostics is demonstrated by species-selective enhancement/annihilation via field-free alignment.