Aberrant epigenetic changes in DNA methylation and histone acetylation are hallmarks of most cancers, whereas histone methylation was previously considered to be irreversible and less versatile. Recently, several histone demethylases were identified catalyzing the removal of methyl groups from histone H3 lysine residues and thereby influencing gene expression. Neuroblastomas continue to remain a c

Using a novel experimental approach based on near-infrared femtosecond absorption spectroscopy, we have determined the energy of the S-1 state of the carotenoid spheroidene. The energy of this state is 13 400 +/- 90 cm(-1) at both 293 and 186 K, showing that there is no temperature-induced shift of the S-1 level. A discrepancy of about 800 cm(-1) between the S-1 energy determined here and that obt

The first analysis to our knowledge of the optical data storage density of photon-echo storage is presented. Mainly considering signal-to-noise ratio performance, we calculate the obtainable storage density for data storage and processing using photon echoes to be approximately 100 times the theoretical limit for conventional optical data storage. This limit is similar to that theoretically calcul

ABSTRACT: BACKGROUND: Antimicrobial peptides (AMP) are important effectors of the innate immune system. Although there is increasing evidence that AMPs influence bacteria in a multitude of ways, bacterial wall rupture plays the pivotal role in the bactericidal action of AMPs. Structurally, AMPs share many similarities with endogenous heparin-binding peptides with respect to secondary structure, ca

Kulturartikel om Steven Spielberg med anledning av John Baxters aktuella biografi..

OBJECTIVES: The aim of this study was to determine if there were any long-lasting elevated anxiety levels in women attending colposcopy after an abnormal cervical smear. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynaecology, Malmö University Hospital, Sweden. POPULATION: One hundred consecutive women were invited to participate when referred for colposcopy. METHODS: Women in

OBJECTIVES: /st> The novel small molecule 9-chloro-2,3-dimethyl-6-(N,N-dimethylaminoethylamino-2-oxoethyl)-6H-indolo[2,3-b] quinoxaline (Rabeximod) reduces severity of arthritis in rodent models of rheumatoid arthritis (RA) and multiple sclerosis (MS). This study aimed to investigate the cellular target in vivo. METHODS: /st> Collagen antibody-induced arthritis (CAIA) is induced by monoclonal coll

The duration of P fertiliser in acid forest soil was investigated in a Norway spruce (Picea abies Karst.) forest in southcentral Sweden. The fertilisation of the soil started in 1967, but no P has been applied since 1988. The N fertilisation is still continuing. Totally, 300 kg P per hectare, as superphosphate, and/or 1090 kg N per hectare, as ammonium nitrate, was applied. Concentrations of both

Recensionav "Kärlek per korrespondens." En analys av kärleksbegreppet och dess innehåll i två brevväxlingar frän senare delen av 1800-talet, skrivna av två par ur borgerligheten. En undersökning av vad det innebar att initiera och bygga upp en kärleksrelation, så som det tar sig uttryck i brev.

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This thesis consists of three essays discussing institutional change and its effects. It distinguishes between economic and political institutions, and highlights the need for broader empirical efforts that consider interactions among different types of institutions. The first essay titled Effect of Trade and Political Institutions on Economic Institutions explores the relationship between trade a