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Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract

BackgroundThe epidemiological association between type 2 diabetes and cataract has been well established. However, it remains unclear whether the two diseases share a genetic basis, and if so, whether this reflects a putative causal relationship.MethodsWe used East Asian population-based genome-wide association studies (GWAS) summary statistics of type 2 diabetes (Ncase = 36 614, Ncontrol = 155 15

Identification of Putative Causal Relationships Between Type 2 Diabetes and Blood-Based Biomarkers in East Asians by Mendelian Randomization

Observational studies have revealed phenotypic associations between type 2 diabetes (T2D) and many biomarkers. However, causality between these conditions in East Asians is unclear. We leveraged genome-wide association study (GWAS) summary statistics on T2D (n = 77,418 cases; n = 356,122 controls) from the Asian Genetic Epidemiology Network (sample recruited during 2001-2011) and GWAS summary stat

DGAT-onco : A differential analysis method to detect oncogenes by integrating functional information of mutations

It is a common strategy to predict oncogenes by differential analysis between somatic mutations and background mutations. Most previous methods only utilize mutations in the cancer population to model its background mutation, which have an obvious bias. A recent method, DiffMut, improves this issue by conducting differential mutational analysis with both mutations in the cancer population and the

Jämkning av kommersiella avtal mellan jämbördiga parter - reflektioner kring 36 § avtalslagen utifrån några aktuella rättsliga avgöranden

Denna artikel förmedlar några iakttagelser från den allmänna avtalsrätten. Det handlar om tillämpningen på senare tid av den ständigt aktuella 36 § i lagen (1915:218) om avtal och andra rättshandlingar på förmögenhetsrättens område (avtalslagen alternativt AvtL) i kommersiella avtalsrelationer. Mina iakttagelser leder till slutsatsen att den starka restriktivitet i tillämpningen som förarbetena ti

Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans

Type 2 diabetes (T2D) is a critical risk factor for peripheral artery disease (PAD). However, the sex differences in genetic basis, causality, and underlying mechanisms of the two diseases are still unclear. Using sex-stratified and ethnic-based GWAS summary, we explored the genetic correlation and causal relationship between T2D and PAD in both ethnicities and sexes by linkage disequilibrium scor

Associations of Macronutrients Intake With MRI-determined Hepatic Fat Content, Hepatic Fibroinflammation, and NAFLD

CONTEXT: A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.OBJECTIVE: This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepat

Mendelian randomization suggests a potential causal effect of eosinophil count on influenza vaccination responsiveness

Currently, the clinical factors affecting immune responses to influenza vaccines have not been systematically explored. The mechanism of low responsiveness to influenza vaccination (LRIV) is complicated and not thoroughly elucidated. Thus, we integrate our in-house genome-wide association studies (GWAS) analysis result of LRIV (N = 111, Ncase [Low Responders] = 34, Ncontrol [Responders] = 77) with

Accurately Identifying Coronary Atherosclerotic Heart Disease through Merged Beats of Electrocardiogram

Coronary Atherosclerotic Heart Disease (CAHD) is one kind of severe heart disease that is the dominating cause of death from non-communicable diseases worldwide. CAHD can be early detected through pre-symptomatic health check-ups, and the electrocardiogram (ECG) is common for non-invasive health check diagnoses. Traditionally, ECG signals are utilized to extract clinical features that are then inp

Genetic and phenotypic relationships between coronary atherosclerotic heart disease and electrocardiographic traits

Observational studies have revealed that Coronary Atherosclerotic Heart Disease (CAHD) is associated with abnormal electrocardiogram (ECG) traits. However, it remains unclear whether there are genetic correlations between ECG and CAHD. Here, we explored genetic correlations and putative causal relationships between CAHD and ECG by performing Mendelian randomization (MR) and Polygenic risk score (P

Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians

BACKGROUND: Observational studies have revealed that type 2 diabetes (T2D) is associated with an increased risk of peripheral artery disease (PAD). However, whether the two diseases share a genetic basis and whether the relationship is causal remain unclear. It is also unclear as to whether these relationships differ between ethnic groups.METHODS: By leveraging large-scale genome-wide association

Associations between ambient air pollution and IVF outcomes in a heavily polluted city in China

RESEARCH QUESTION: Is air pollution related to IVF outcomes in a heavily polluted city in China?DESIGN: A retrospective cohort study of 8628 fresh, autologous IVF cycles was conducted for the first time at the Reproductive Medicine Center of The Third Affiliated Hospital of Zhengzhou University between May 2014 and December 2018 (oocyte retrieval date). The exposure was divided into four periods (

Characterization of key amino acid substitutions and dynamics of the influenza virus H3N2 hemagglutinin

The annual epidemics of seasonal influenza is partly attributed to the continued virus evolution. It is challenging to evaluate the effect of influenza virus mutations on evading population immunity. In this study, we introduce a novel statistical and computational approach to measure the dynamic molecular determinants underlying epidemics using effective mutations (EMs), and account for the time

Chem2Side : A Deep Learning Model with Ensemble Augmentation (Conventional + Pix2Pix) for COVID-19 Drug Side-Effects Prediction from Chemical Images

Drug side effects (DSEs) or adverse drug reactions (ADRs) are a major concern in the healthcare industry, accounting for a significant number of annual deaths in Europe alone. Identifying and predicting DSEs early in the drug development process is crucial to mitigate their impact on public health and reduce the time and costs associated with drug development. Objective: In this study, our primary

Foreign Policy Analysis and Securitization

To what extent can securitization theory help us to engage with the puzzles and problems of foreign policy analysis (FPA)? And how can FPA scholarship contribute to the development of the assumptions of securitization? This chapter will probe these questions and attempt to demonstrate that these seemingly disparate research traditions indeed both complement and inform one another. Securitization t

The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease

Background and aims: Several susceptibility gene variants predisposing to nonalcoholic fatty liver disease (NAFLD) have been identified in chronic kidney disease (CKD). Evidence supports that 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 plays a role in NAFLD development by affecting lipid homeostasis. Since lipid droplets may accumulate in the kidneys and contribute to renal injur

MAFLD and risk of CKD

Background/aims: Whereas nonalcoholic fatty liver disease (NAFLD) is a multisystem disease, the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and extra-hepatic diseases is not known. The aim of this cross-sectional study was to compare the prevalence of chronic kidney disease (CKD) in patients with either MAFLD or NAFLD, and then to examine the association betwee

Association between NAFLD and risk of prevalent chronic kidney disease : Why there is a difference between east and west?

Backgrounds: There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. Methods: Two health examination datasets from China and the U

Effectiveness of traditional chinese exercise for symptoms of knee osteoarthritis : A systematic review and meta-analysis of randomized controlled trials

Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effect

Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD

Aim: The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty liver disease (NAFLD). Materials and methods: A total of 214 adults with non-c

Sectioning protocol determines accuracy of intraoperative pathological examination of sentinel lymph node in cervical cancer : A systematic review and meta-analysis

Objectives: To determine the diagnostic performance and optimal protocol of frozen section examination (FSE) in SLNB for cervical cancer. Methods: PubMed, EMBASE, Web of Science, Cochrane Library, Wanfang Data and China National Knowledge Infrastructure were searched from inception to July 30, 2019, for studies concerning SLNB with FSE in cervical cancer. Sensitivity of FSE in detecting SLN metast