In the vicinity of metallic nanostructures, absorption and emission rates of optical emitters can be modulated by several orders of magnitude1,2. Control of such near-field light-matter interaction is essential for applications in biosensing3, light harvesting4 and quantum communication5,6 and requires precise mapping of optical near-field interactions, for which single-emitter probes are promisin

Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or pulmonary embolism. The underlying key receptor distributions and interactions, in particular the relevance of integrin clustering, are not fully under

Single-molecule localization microscopy (SMLM) aims for maximized precision and a high signal-to-noise ratio1. Both features can be provided by placing the emitter in front of a metal-dielectric nanocoating that acts as a tuned mirror2-4. Here, we demonstrate that a higher photon yield at a lower background on biocompatible metal-dielectric nanocoatings substantially improves SMLM performance and

DNMT3A/3L heterotetramers contain two active centers binding CpG sites at 12 bp distance, however their interaction with DNA not containing this feature is unclear. Using randomized substrates, we observed preferential co-methylation of CpG sites with 6, 9 and 12 bp spacing by DNMT3A and DNMT3A/3L. Co-methylation was favored by AT bases between the 12 bp spaced CpG sites consistent with their incr

Fluorescence microscopy allows specific and selective imaging of biological samples. Unfortunately, unspecific background due to auto-fluorescence, scattering, and non-ideal labeling efficiency often adversely affect imaging. Surface plasmon-coupled emission (SPCE) is known to selectively mediate fluorescence that spatially originates from regions close to the metal interface. However, SPCE combin

The maker movement has reached the optics labs, empowering researchers to create and modify microscope designs and imaging accessories. 3D printing has a disruptive impact on the field, improving accessibility to fabrication technologies in additive manufacturing. This approach is particularly useful for rapid, low-cost prototyping, allowing unprecedented levels of productivity and accessibility.

We propose symmetrical cationic trimethine cyanine dyes with β-substituents in the polymethine chain based on modified benzothiazole and benzoxazole heterocycles as probes for the detection and visualization of live and fixed cells by fluorescence microscopy. The spectral-luminescent properties of trimethine cyanines have been characterized for free dyes and in the presence of nucleic acids (NA) a

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment

Vegetation is the major source of volatile organic compounds (VOCs) in the atmosphere, which affect both air quality and climate. Long-term ecosystem-level data on biogenic VOC (BVOC) emissions, however, are limited. This is especially true regarding the impacts of landscape-scale disturbances like clear-cutting on the short-term and longer seasonal-scale emissions of boreal forests, particularly

Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand

Under slutet av 1900-talet var den svenska reformtakten hög vilket gjorde ekonomin konkurrenskraftig och att Sverige klarade finanskrisen 2008–2010 bättre än jämförbara länder. Nu har reformtakten avtagit och den ekonomiska friheten är fallande på flera områden. I en ny rapport från Entreprenörskapsforum konstateras att 2010-talet blev ett i allt väsentligt förlorat decennium med minskad ekonomisk

Denna artikel behandlar fyndet av en kota från en bardval som påträffades under utgrävningarna av Västra Karaby, en vendeltida boplats i västra Skåne. Fynd av bardvalar i skånska järnåldersboplatser är mycket sällsynta. I artikeln diskuteras kotans proveniens, kronologiska tillhörighet och betydelse för förståelsen av boplatsen. En taxonomisk bestämning av kotan har gjorts genom den benkemiska pep

Bimetallic nanoparticles exhibit unique physicochemical characteristics that often translateinto functional properties surpassing those of their monometallic counterparts. The abilityto precisely tailor these characteristics enables fine-tuning of their properties for targetedapplications. This doctoral thesis investigates the engineering of bimetallic nanoparticlesvia spark ablation, a continuous

Quasi-markets in the provision of public services are increasingly common but also highly contested. We formulate a conceptual framework based on economic theory to describe how quasi-markets differ from traditional markets in five aspects: 1) revenues, costs, and profits; 2) the matching of supply and demand; 3) competition; 4) structural change; and 5) rent-seeking. Using the assumption of profi

Neuroendocrine tumours (NETs) of the small intestine (siNET) are slow-growing malignancies often diagnosed at an advanced stage. Despite their indolent nature, patients frequently experience significant symptoms, including carcinoid syndrome (CS) with diarrhoea, which impact their health-related quality of life (HRQoL). This thesis investigates the determinants of HRQoL in siNET patients, its prog

Recension av Daniel Pedersen, Natt och aska – Förintelsens litteratur.