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Prenatal Diagnosis of Haemophilia - psychological, social and ethical aspects

Popular Abstract in Swedish Hemofili (blödarsjuka) A och B, är X-kromosomalt, recessivt, nedärvda sjukdomar som orsakas av brist på eller avsaknad av koagulationsfaktor VIII respektive IX i blodet (FVIII och FIX). Sjukdomen drabbar män och överförs till nästa generation av kvinnliga bärare, som vanligtvis inte själva har några blödnings-symtom. Blödarsjuka ger redan tidigt i livet upphov till blödThe general aim of this study has been to study the psychological, social and ethical aspects for carriers of haemophilia and their spouses, related to the development of techniques for carrier testing and for prenatal diagnosis (PD) of haemophilia. This was investigated by a semi-structured follow-up interview with 29 carriers of haemophilia with experience of PD by fetal blood sampling (FBS), an

Extrapolation in Time in Thermal Fluid Structure Interaction

We consider time dependent thermal fluid structure interaction. The respective models are the compressible Navier-Stokes equations and the nonlinear heat equation. A partitioned coupling approach via a Dirichlet-Neumann method and a fixed point iteration is employed. As a reference solver a previously developed efficient time adaptive higher order time integration scheme is used. To improve upon t

Analytical expression of the efficiency of phantom zero compensation applied on negative-feedback amplifiers

This article reviews the phantom zero compensation technique, applied on negative-feedback (NFB) amplifiers, followed by an analysis of the important efficiency parameter, 0, of the implemented phantom zero. The effect of the efficiency on the root locus is presented, and it has been found that δ 7 will give near ideal behavior of the applied phantom zero. A reduced small signal model of the ampli

A Global Overview of Bio-economy Strategies and Visions

This overview provides a comparative analysis of strategies and visions for the bio-economy. It concentrates on the US, EU, Finland, Germany, Sweden, Canada and Australia. It comments on China, Russia, Brazil and Malaysia. It also briefly outlines the OECD policy agenda for the bio-economy.

Myoelectric Control for Hand Prostheses

Popular Abstract in Swedish Denna avhandling syftar till att förbättra styrningen av myoelektriska handproteser. De primära målen har varit (1) att generera korrekt kontroll för så många handrörelser som möjligt, (2) att förbättra träningsförfarandet så att operatören på ett intuitivt sätt snabbt kan bemästra ett flertal rörelser och (3) att minska tiden som behövs för att matematiskt justera in sAn investigation of improvements of myoelectric prostheses has been undertaken. The primary aims of this thesis were (1) to generate an accurate prediction of as many hand movement as possible, (2) to produce a training setup for subjects allowing intuitive and instant control over multiple movements, and (3) to reduce the training cycle for the control system to a maximum of a couple of minutes t

Chondrocyte-matrix interactions: with emphasis on the collagen binding integrin a10ß1

Popular Abstract in Swedish Vår kropp är uppbyggd av flera olika typer av stödjevävnader tex ben, brosk, muskler och hud. Den utgör kroppens stomme och bidrar med både stödjande och elastiska funktioner i kroppen. Brosk är en specialiserad form av bindväv som bekläder alla ledytor i kroppen och dess specifika sammansättning förser leden med en i det närmaste friktionslös rörelseförmåga. Broskets The work in this thesis has been focused on chondrocyte integrins and their interaction with the matrix proteins chondroadherin (CHAD) and collagen type II (CII). Affinity purification of CHAD-binding proteins from chondrocyte lysate, followed by immunoprecipitation of EDTA-eluted material identified alpha2beta1 as a CHAD-binding integrin. Interaction between alpha2beta1 and CHAD was found to prev

Beta-Lactamase in Haemophilus ducreyi: Purification, Characterization, and Mutagenesis

Chancroid caused by Haemophilus ducreyi, has been described as a significantly predisposing factor of HIV heterosexual transmission in an endemic region of both diseases. Antibiotic resistances are extensively found in H. ducreyi and many of the resistances are due to the presence of resistance plasmids. A high tendency of drug resistances has commonly been found among isolates derived in Thailan

Production of Ethanol from Spruce at High Solids Concentrations - An Experimental Study on Process Development of Simultaneous Saccharification and Fermentation

Popular Abstract in Swedish Intresset för förnybara bränslen har ökat stadigt under de senaste åren. Att byta ut fossila mot förnybara bränslen kan minska utsläppen av växthusgaser till atmosfären och därmed minska klimatpåverkan av dessa men även minska vårt beroende av olja. Biobränslen som t.ex. etanol, biodiesel eller biogas, räknas till förnybara bränslen eftersom de inte bidrar till en ackumReplacing fossil fuels by biofuels such as ethanol is considered a promising alternative to reduce greenhouse gas (GHG) emissions and mitigate climate change. Biofuels produced from lignocellulosic biomass, so-called second generation biofuels, result in decreased GHG emissions and limit competition with food and animal feed production. Interest in producing ethanol from lignocellulosic biomass ha

Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly

The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. In the first paper, a model of cartilage degradation is