Background: Parkinson's disease (PD) diagnosis is mainly based on clinical criteria, with a high risk of misdiagnosis. The identification of reliable biomarkers for disease diagnosis and progression has a key role for developing disease-modifying therapies. In this article, we investigated the longitudinal changes of CSF α-synuclein species in early PD patients and explored the potential use of th

We report growth and characterization of a coupled quantum dot structure that utilizes nanowire templates for selective epitaxy of radial heterostructures. The starting point is a zinc blende InAs nanowire with thin segments of wurtzite structure. These segments have dual roles: they act as tunnel barriers for electron transport in the InAs core, and they also locally suppress growth of a GaSb she

Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective phytotoxins. Alt a 1 is a strongly allergenic protein found in A. alternata that causes severe asthma. Despite the well-established pathogenicity of Alt a 1, the molecular mechanisms underlying its action and physiological function r

The European Spallation Source (ESS), scheduled to start operation in 2020, is aiming to deliver the most intense neutron beams for experimental research of any facility worldwide. Its long pulse time structure implies significant differences for instrumentation compared to other spallation sources which, in contrast, are all providing short neutron pulses. In order to enable the development of me

Allergic contact dermatitis (ACD) initiated by chemical sensitizers is an important public health concern. To prevent ACD, it is important to identify chemical allergens to limit the use of such compounds in various products. EU legislations, as well as increased mechanistic knowledge of skin sensitization have promoted development of non-animal based approaches for hazard classification of chemic

Extracellular vesicles (ECVs), including microparticles and exosomes, are submicrometer membrane vesicles released by diverse cell types upon activation or stress. Circulating ECVs are potential reservoirs of disease biomarkers, and the complexity of these vesicles is significantly lower compared to their source, blood plasma, which makes ECV-based biomarker studies more promising. Proteomic profi

This article identifies factors which contribute to households’ willingness to pay for improving and protecting a multiple-use water scheme in Ethiopia. It does so through descriptive statistics, a probit model and contingent valuation methods complemented with qualitative data. Estimates suggest farmers’ willingness to pay is based on gender, the prevalence of waterborne disease, the time to coll

Den boghistoriske afhandling »Den skandinaviske encyklopædi. Udgivelse og udformning af Nordisk familjebok og Salmonsens Konversationsleksikon« undersøger for første gang encyklopædiens historie og udvikling i Skandinavien. Fokus er frem for alt på de to standardsættende udgivelser Salmonsens Konversationsleksikon og Nordisk familjebok. Gennem deres position som Danmarks og Sveriges første nationa

The computing grid is a distributed parallel processing system that share and choosing resources dynamically and provide need of user operation power, cost and quality .grid management resources does as a diagnostic and assigning resources scheduling and resource monitoring in grid . Scheduling process directs tasks to suitable resources. It must take place some how that load work distributed equa

The electrophysiological effects of pentisomide upon the intact human heart were evaluated using programmed stimulation and recording of intracardiac monophasic action potentials (MAP) in 17 patients with various ventricular arrhythmias. After i.v. administration of pentisomide, 85-135 mg, the atrial-His interval increased by 8 +/- 12 ms (p less than 0.05) during sinus rhythm and by 13 +/- 21 ms (

There are important applied and theoretical reasons for research into the association between social desirability and self-reported anxiety in young people. The aim of this study was to examine the relationship between anxiety and social desirability in a large normative sample of 7- to 14- year-olds (N = 1,786). Participants Completed the Revised Children's Manifest Anxiety Scale and their teache

This study investigated the characteristics of each of the specific DSM- III-R (American Psychiatric Association, 1987) anxiety disorders in a clinic sample of 188 anxiety disordered children. Characteristics examined included sociodemographic variables (age-at-intake, gender, and race of the child, and family marital and socioeconomic status) and clinical variables (disorder age-at-onset and seve