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Tuning phase transitions of aqueous protein solutions by multivalent cations

In the presence of trivalent cations, negatively charged globular proteins show a rich phase behaviour including reentrant condensation, crystallisation, clustering and lower critical solution temperature metastable liquid–liquid phase separation (LCST–LLPS). Here, we present a systematic study on how different multivalent cations can be employed to tune the interactions and the associated phase b

Safety and Effectiveness of Vedolizumab in Patients with Steroid-Refractory GI Acute GvHD : A Retrospective Record Review

Allogeneic hematopoietic cell transplantation can be curative in patients with hematological malignancies but carries a significant risk of graft-versus-host disease (GvHD). There are no standard treatments for steroid-refractory (SR) gastrointestinal (GI) acute GvHD (aGvHD). This multicenter, international, retrospective medical record review aimed to evaluate the off-label use of vedolizumab, a

Beyond humanities qua digital : Spatial and material development for digital research infrastructures in HumlabX

Universities around the world have increasingly turned to digital infrastructures as a way to revamp the arts and humanities. This article contributes a fresh understanding by examining the material development of HumlabX, a research laboratory for digital humanities at Umea° University, Sweden. Specifically, we approach the empirical case as a timeline of research funding, projects, events, and d

Historiska perspektiv på den katolska kyrkan och demokratin

I vår tid framträder katolska kyrkan som en ivrig försvarare av mänskliga rättigheter och demokrati. Så har det inte alltid varit. I själva verket var det först med andra vatikankonciliet (1962-1965) som dessa idéer integrerades i den katolska socialdoktrinen. Erkännandet av de mänskliga rättigheterna och den liberala demokratin som ett fundament för samhällsordningen innebar en omvälvande nyorien

Development and Psychometric Exploration of the Anesthesia Surrendering Instrument (ASI)

PurposeThe aim of this study was to develop and test an instrument to measure surrendering at the time of anesthesia induction and to explore the construct validity.DesignAn instrumental cross-sectional design was used and construct validity was evaluated via psychometric testing.MethodsThe anesthesia surrendering instrument (ASI) comprised 36 items. A total of 202 adults (older than 18 years) ans

Nationwide Study on Treatment of Mycotic Thoracic Aortic Aneurysms

Objective/background: Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic aortic aneurysms (MTAAs). Methods: Patients treated in Sweden for MTAAs between 2000 and 2016 were identified in the Swedish vascular registry (2010–16) and local patient registries (2000–09). Primary outcome was survival, and second

Late mortality and morbidity among long-term leukemia survivors with Down syndrome : A nationwide population-based cohort study

Background: Late health consequences of treatment for childhood leukemia are well documented. Although individuals with Down syndrome (DS) have a substantially increased risk of leukemia, information on late effects in this group is almost nonexistent. The aim of this study was to evaluate the mortality and morbidity among 5-year leukemia survivors with DS. Procedure: We compared 5-year leukemia s

Country of ownership change in the premium segment : consequences for brand image

Purpose: This paper aims to explore how the ownership transfer from a highly industrialised country to less industrialised countries influences consumers’ brand perceptions. Design/methodology/approach: Three acquisition cases of premium car brands (Jaguar, Land Rover and Volvo) are investigated using qualitative data from online brand communities. Findings: When country of ownership (COOW) for br

Multilingualism as Problem or Resource? : Negotiating Space for Languages Other than Swedish and English in University Language Planning

In the Nordic countries, university language policy and planning centres on balancing the use of the national language(s) vis-à-vis English, whereas less attention has been paid to the roles played by other languages. This study focuses on how space was negotiated for languages other than Swedish and English during language policy negotiations at a Swedish university. Using an ethnographic discour

Non-invasive monitoring of protein adsorption and removal in a turbulent flow cell

A flow cell was designed for continuous non-invasive measurements of macromolecular adsorption and removal under well-defined flow conditions. The adsorption of the protein β-lactoglobulin to stainless steel surfaces and its subsequent detergent-induced removal were followed in the flow cell using in situ ellipsometry under both laminar and turbulent conditions. Factors varied include the cleaning

Stability of Uncertain Systems with Hysteresis Nonlinearities

Stability of systems with hysteresis nonlinearities, parametric uncertainty and finite dimensional unmodelled dynamics is considered. Conditions for exponential decay of the signals in the system to an equilibrium position are given. The equilibrium is generally not unique. The stability condition is given in terms of a frequency domain inequality, which involves the transfer function of the nomin

Implementation of concurrent Pascal on LSI—11

This paper considers the moving of the implementation of Concurrent Pascal for the PDP‐11/45 computer to the LSI‐11 computer. The resulting implementation for the LSI‐11 computer is also discussed and described

Near-haploidy in a case of plasmocytoma

Chromosome studies of a solitary plasmocytoma in the femoral bone revealed a near-haploid chromosome number of 31-32 with a loss of one homolog of each chromosome pair except #1, #7, #9, #15, #19-21, and the sex chromosomes (XY). The cytogenetic findings have been compared with 16 cases of near-haploid neoplasms from the literature studied using banding techniques. A common feature present in 13 o