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Background: Osteoarthritis (OA) and inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondylarthritis (axSpA), are leading causes of disability worldwide, significantly impacting health and quality of life. Sleep issues are highly prevalent in these populations, exacerbating pain, fatigue, and disease activity. However, there is a dearth of evi

This special issue introduction explores dialogic organizing centred on affirming public engagement for hope and solidarity. We propose ways of retheorizing and revitalizing dialogic perspectives and practices. In so doing we take our cue a Bakhtinian understanding of dialogue; however, we suggest that it is necessary to move beyond this foundational understanding. Instead, it needs to be read in

Cellular senescence, a phenomenon characterized by the accumulation of dysfunctional, metabolically active cells, is increasingly recognized to be a key player in aging-related metabolic disorders. It is accelerated by hyperglycemia through various molecular pathways, positioning it as a critical mechanism in the pathophysiology of type 2 diabetes mellitus (T2D) and a potential therapeutic target.

In this work, we explore Higgs boson decays into dark matter (DM) within the context of the freeze-in mechanism under stronger coupling scenarios. Our analysis focuses on scalar DM candidates interacting through the Higgs portal, where the coupling strength can be significant without establishing thermal equilibrium, owing to a suppressed reheating temperature. We find that for DM masses as low as

Structural optimization aims to find the geometry of the best performing design in a predefined setting, using mathematical techniques. The motivation for this study can be categorized into three main benefits: efficient material usage, enhancing existing designs and enabling new technologies. All of these benefits are crucial for solving contemporary technological and environmental challenges. An

Large amounts of dendrochronological data sets exported from the SEAD databasehave in this study been used to analyze timber trade and provenance from thethree Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburgduring the medieval and early modern era. In total, 964 dendrochronologicalsamples with a dating and provenance description were compiled in this studyand compared with wrLarge amounts of dendrochronological data sets exported from the SEAD database have in this study been used to analyze timber trade and provenance from the three Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburg during the medieval and early modern era. In total, 964 dendrochronological samples with a dating and provenance description were compiled in this study and compared wi

The end-Permian mass extinction greatly affected the sedimentary record, but the sedimentary response was not limited to the Permian-Triassic boundary interval. This transformation extended to sedimentation that spanned the entire Early Triassic. Calcimicrobialites play an important role throughout this time interval, and at least four main events of anomalous carbonate deposition can be shown. A

Star clusters stand at the crossroads between galaxies and single stars. Resolving the formation of star clusters in cosmological simulations represents an ambitious and challenging goal, since modelling their internal properties requires very high resolution. This paper is the third of a series within the SImulating the Environment where Globular clusters Emerged (SIEGE) project, where we conduct

Objective: The aim of this study was to assess the incremental cost-effectiveness of on-demand versus prophylactic hemophilia therapy in Iran from a third-party payers’ perspective.Methods: A retrospective chart review of twenty-five type A hemophiliacs who were treated in three hemophilia treatment centers was conducted. The patients were boys 0–9 years old receiving one of two treatments: (i) pr

The Permian-Triassic Boundary sequence at Çürük Dag, near Antalya, Turkey, begins with a major erosion surface interpreted as being the Late Permian lowstand, on which lies ca 0·4m of grainstone/packstone composed of ooids, peloids and bioclasts. Most ooids are superficial coats on fragments of calcite crystals presumed to be eroded from crystal fans which are no longer present. The erosion surfac

Background: The impact of surgical specialization on long-term survival in patients undergoing emergent colon cancer resections remains unclear. Method: A retrospective analysis was conducted on all patients who underwent emergent colon cancer resections at a secondary care hospital between 2010 and 2020. The most senior surgeon performing the procedures was classified as colorectal surgeon (CS) o

Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe

Background The optimal strategy for initial treatment of acute occlusion of superior mesenteric artery (SMA) is debated. The aim of the study was to compare the effectiveness, timelines and outcomes of endovascular versus open surgical treatment in patients with acute SMA occlusion. This was a preplanned substudy of the prospective observational multicenter AMESI (Acute MESenteric Ischaemia) study

Flat bands can induce strong electron correlation effects that help stabilize both magnetic and superconducting states. Here, we carry out angle-resolved photoemission spectroscopy and density functional theory calculations to study the electronic structure of the Co-pnictides CaCo2As2 and LaCo2P2. We find that the kz Fermi topology of ferromagnetic LaCo2P2 is markedly two-dimensional, while the a

β-Alanine synthase (βAS), which is a dizinc metalloenzyme, catalyzes the irreversible hydrolysis of N-carbamyl-β-alanine (NCβA) to β-alanine. This enzyme has potential applications for β-amino acid production. Understanding the reaction mechanism and selectivity of βAS at atomic details can help design and engineer the enzyme for cascade biocatalysis. Here, the protonation states of two conserved

The end Permian negative δ13C excursion is well known but its cause and chronology are still in question. In an attempt to decipher the timing and reasons for this strong decrease, we established high-resolution sedimentological, biostratigraphical and carbonate carbon isotopic studies in four sections in Iran (Abadeh, Shareeza, Zal and Djulfa) and two in Oman (Wadi Sahtan). The position of the se

One of the major recent breakthroughs has been the discovery of the last major merger to happen in the history of the Milky Way. Around 10 Gyr ago, the galaxy Gaia Enceladus with an estimated ∼10% of the Milky Way mass, fell into the potential of our Galaxy, bringing a large amount of stars that can be identified through their unique chemical and kinematic signatures. Simulations have long predict