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Activation of the complement system and resulting opsonisation with C3b are key events of the innate immune defense against infections. However, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as C4b-binding protein, factor H and vitronectin, which results in diminished opsonophagocytosis and killing of bacteria by lysis. Another widely us
While research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support has not emerged so far, and thus the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high abstraction levels makes the quality of the resulting im
The purpose of this thesis is to obtain microlocal analogues of results by L. Hörmander about inclusion relations between the ranges of first order differential operators with smooth coefficients which fail to be locally solvable. Using similar techniques, we shall study the properties of the range of classical pseudo-differential operators of principal type which fail to satisfy condition (ψ).
Natural radiative lifetimes of 20 levels (energy range between 20 000 35 000 cm(-1)) in Cd II and 5 levels (energy range between 43 000-49 000 cm(-1)) in Gd III have been measured using time-resolved laser-induced fluorescence III a laser-produced plasma.
OBJECTIVE: To study the influence of gestational age on lactate concentration in arterial and venous umbilical cord blood at birth and to define gestational age-specific reference values for lactate in vigorous newborns. DESIGN: Population-based comparative. SETTING: University hospitals. SAMPLE: Vigorous newborns with validated umbilical cord blood samples. MATERIAL AND METHODS: From 2000 to 2004
Abstract The identification of patients carrying extended-spectrum beta-lactamase (ESBL)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. The purpose of this study was to investigate the occurrence of ESBL-producing bacteria in patients with travellers' diarrhoea. Patients with travellers' diarrhoea (N = 242) ha
Constrained by national tests and the mathematics curriculum, teachers have problems finding time for exploratory and hands-on mathematical activities, especially so in classes with a reduced pace of progression, for example because of a large proportion of second-language learners. Could the leisure-time center, where time is not earmarked, provide such opportunities? The conclusion of this thesi
In this paper, we discuss common features found in what we term trade languages. Some languages change their grammatical shape dramatically after intense contacts with other languages. Pidgin and creole languages are often discussed in terms of contacts, but trade languages are slightly different from them on the following points: trade languages are normally formed with mutually intelligible lang
Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis after current clinical therapy. Although immunotherapy of experimental gliomas has been demonstrated to have the capacity to cure intracerebral tumors no convincing effects of immunotherapy have been shown in clinical trials. One reason for this could be that some of the models used do not display f
Background: In diagnosing acute pulmonary embolism (PE) in azotemic patients, scintigraphy and magnetic resonance imaging are frequently inconclusive or not available in many hospitals. Computed tomography is readily available, but relatively high doses (30-50 g I) of potentially nephrotoxic iodine contrast media (CM) are used. Purpose: To report on the diagnostic quality and possible contrast-ind
Dietary carbohydrates have been implicated in relation to prostate cancer.
Spontaneous movements are a ubiquitous phenomenon during development. Recently, we demonstrated that these movements play a key role in the functional adaptation of spinal reflex circuits. Here, we analyse the role of afferent input in the generation of spontaneous movements and characterize the occurrence of different types of spontaneous movements and their relation to the functional adaptation
GADS is a member of a family of SH2 and SH3 domain-containing adaptors that functions in tyrosine kinase-mediated signaling cascades. Its expression is largely restricted to hematopoietic tissues and cell lines. Therefore, GADS is mainly involved in leukocyte-specific protein tyrosine kinase signaling. GADS is known to interact with tyrosine-phosphorylated SHC, BCR-ABL and KIT. The SH2 domain of G
We studied the effects of the national Perinatal Patient Safety Program in Sweden, addressing local improvement measures, changes in the proportion of low Apgar Score and the number of settled injury claims due to asphyxia.
BACKGROUND: Lead time, the estimated time by which screening advances the date of diagnosis, is used to calculate the risk of overdiagnosis. We sought to describe empirically the distribution of lead times between an elevated prostate-specific antigen (PSA) and subsequent prostate cancer diagnosis. METHODS: We linked the Swedish cancer registry to two independent cohorts: 60-year-olds sampled in 1
