The major aim of our current work is to develop a deep understanding of biological effects of nanoparticles and how these effects are mediated by proteins that are adsorbed on the nanoparticles under different biological circumstances. Due to their small size, nanoparticles have distinct properties compared to the bulk form of the same materials, and these properties are rapidly revolutionizing ma

The FFT processor is used for OFDM-based UWB wireless communication system. 64/128 points FFT is employed in the processor by using mixed-radix algorithm to meet the requirement of different UWB systems. The FFT processor, using the pipelined parallel structure, the register reusing architecture and the shift-add algorithm, can reach a device utilization of 100% and a 500MS/s throughput rate(FPGA

The effect of photodynamic therapy on tape-stripped normal human skin was explored ultrastructurally. Back skin areas of 3 healthy Caucasian volunteers, 2 men and 1 woman, were tape-stripped 10 consecutive times followed by topical treatment with 5-aminolevulinic acid (20%, w/w) for 4 hours under occlusion (Tegaderm(R)). Then the areas were irradiated for 30 minutes with Waldman PDT 1200 lamp (570

The small heat shock proteins (sHsps) possess a chaperone-like activity which prevents aggregation of other proteins during transient heat or oxidative stress. The sHsps bind, onto their surface, molten globule forms of other proteins, thereby keeping them in a refolding competent state. In Hsp21, a chloroplast-located sHsp in all higher plants, there is a highly conserved region forming an amphip

Amperometric biosensors based on corresponding dehydrogenases have been developed for the determination of ethanol, glucose and glycerol. The enzymes have been integrated in redox hydrogels using an Os complex-modified non-conducting polymer employed as the electrochemical mediator and poly(ethyleneglycol)-diglycidyl ether (PEGDGE) as the cross-linking agent. The developed biosensors showed a sens

A method for analysis of urinary methylhexahydrophthalic acid (MHHP acid), a metabolite of the highly sensitising methylhexahydrophthalic anhydride, is described. The method is based on a double liquid-solid extraction of the MHHP acid from urine, esterification with methanol and boron trifluoride catalysis, and analysis with gas chromatography-mass spectrometry in the electron impact mode. The de

Popular Abstract in Swedish Denna avhandling behandlar utvecklingen av den norsk-svenska freden mellan 1905-1940. Efterhand kom denna relation att närma sig Stabil Fred—ett förhållande karaktäriserat av avsaknaden av militärt våld, hot om militärt våld, och förväntningar på hot om militärt våld. Utvecklingen mot Stabil Fred smammanfaller delvis med den svenska demokratiseringen, och författaren uThis study concerns the development of Stable Peace between states in the modern anarchical international system. As a starting point for the inquiry the author argues that the prevalence of this type of interstate relationships—characterized by the mutual expectations that neither military violence nor threats thereof will be employed—may be seen as a fundamental challenge to the validity of prev

Mixtures of an amphiphilic graft copolymer in water/sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/cyclohexane oil-continuous microemulsions are studied by the PGSE NMR technique and by viscometry. The graft copolymer has an oil-soluble poly(dodecyl methacrylate) backbone and water-soluble poly(ethylene glycol) side chains. Water, surfactant, and polymer self-diffusion coefficients can be measured

Popular Abstract in Swedish Varje år nydiagnostiseras cirka 2 000 personer med blåscancer i Sverige. Blåscancer drabbar främst män och är för närvarande den femte vanligaste cancerformen bland män efter prostata-, hud,- lung- och koloncancer. Risken att insjukna i blåscancer ökar med ålder och merparten av nydiagnostiserade patienter är över 60 år. Blåscancer är en heterogen sjukdom med avseende pThe general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. We also investig

Aim: To analyse incidences and find risk groups in children hospitalized with hand injuries in a national retrospective study. Methods: All children with a primary hand or forearm injury admitted to Swedish hospitals during 1987 - 2001 were retrieved from the Swedish Hospital Discharge Register and analysed as to incidence and characteristics. Results: Among 9855 children included, the median age

Three types of estimator of the second spectral moment of a stationary Gaussian process are considered. The integral estimator is based on the integral of the squared derivative of the process, while crossing estimators make use of the number of upcrossings of zero or nonzero levels. It is shown that the zero-crossing estimator can often compete with the integral estimator in efficiency and that i

Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH pa

Bacterial diversity of the mucosal biopsies from human jejunum, distal ileum, ascending colon and rectum were compared by analysis of PCR-amplified 16S rDNA clone libraries. A total of 347 clones from the mucosal biopsies were partially sequenced and assigned to six phylogenctic phyla of the domain Bacteria: Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, Verrucomicrobia, and Actinobacter