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Gaia on-board metrology: basic angle and best focus

The Gala payload ensures maximum passive stability using a single material, SiC, for most of its elements. Dedicated metrology instruments are, however, required to carry out two functions: monitoring the basic angle and refocusing the telescope. Two interferometers fed by the same laser are used to measure the basic angle changes at the level of pas (prad, micropixel), which is the highest level

MAPK/NF-kappa B-dependent upregulation of kinin receptors mediates airway hyperreactivity: A new perspective for the treatment

Airway hyperreactivity (AHR) is a major feature of asthmatic and inflammatory airways. Cigarette smoke exposure, and bacterial and viral infections are well-known environmental risk factors for AHR, but knowledge about the underlying molecular mechanisms on how these risk factors lead to the development of AHR is limited. Activation of intracellular mitogen-activated protein kinase (MAPK)/nuclear

Systematic evaluation of observational methods assessing biomechanical exposures at work

Objectives This systematic review aimed to identify published observational methods assessing biomechanical exposures in occupational settings and evaluate them with reference to the needs of different users. Methods We searched scientific databases and the internet for material from 1965 to September 2008. Methods were included if they were primarily based on the systematic observation of work, t

Socio-cultural retailing: What can marketing learn from this interdisciplinary field?

Purpose – The purpose of this paper is to contribute to the on-going cultural turn in retail marketing by offering an overview of the interdisciplinary field of socio-cultural retailing and discussing how this body of work can contribute conceptually, methodologically and substantively to the field of retail marketing.Design/methodology/approach – This paper is based on a literature review of soci

Docetaxel-Loaded Fluorescent Liquid-Crystalline Nanoparticles for Cancer Theranostics.

Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess targ

Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.

Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age

DO3SE modelling of soil moisture to determine ozone flux to forest trees

The DO3SE (Deposition of O-3 for Stomatal Exchange) model is an established tool for estimating ozone (O-3) deposition, stomatal flux and impacts to a variety of vegetation types across Europe. It has been embedded within the EMEP (European Monitoring and Evaluation Programme) photochemical model to provide a policy tool capable of relating the flux-based risk of vegetation damage to O-3 precursor

Neuromuscular exercise as treatment of degenerative knee disease.

Exercise is recommended as first-line treatment of degenerative knee disease. Our hypothesis is that neuromuscular exercise is feasible and at least as effective as tradionally used strength or aerobic training, but aims to more closely target the sensorimotor deficiencies and functional instability associated with the degenerative knee disease than traditionally used training methods.SUMMARY FOR

Stability of Negatively Charged Platelets in Calcium-Rich Anionic Copolymer Solutions

Controlling the stability of anisotropic particles is key to the development of advanced materials. Here, we report an investigation, by means of mesoscale molecular dynamics simulations, of the stability and structural change of calcium-rich dispersions containing negatively charged nanoplatelets, neutralized by calcium counterions, in the presence of either comb copolymers composed of anionic ba

Measuring Structural Inhomogeneity of Conjugated Polymer at High Pressures up to 30 GPa

We present X-ray scattering data from helical poly[9,9-bis(2-ethylhexyl)-fluorene-2,7-diyl] by mapping the sample with 10 mu m spatial resolution at pressures up to 31 GPa. Neon is used as pressure transmitting medium. Reduction of torsion angle between adjacent repeats is observed during compression and found to be reversible upon decompression. Chain conformation does not depend on lateral posit

Detection of flow direction in high-flying insect and songbird migrants

Goal-oriented migrants travelling through the sea or air must cope with the effect of cross-flows during their journeys if they are to reach their destination [1–3] . In order to counteract flow-induced drift from their preferred course, migrants must detect the mean flow direction, and integrate this information with output from their internal compass, to compensate for the deflection. Animals ca

Pancreatic cancer - cost for overtreatment with gemcitabine.

Gemcitabine has been the standard chemotherapeutic agent in pancreatic cancer. However, two-thirds of pancreatic tumors display low expression of human equilibrative nucleoside transporter 1 (hENT1), which mediates cellular entry of the drug, and do not respond to gemcitabine therapy. The objective was to determine the costs of gemcitabine overtreatment and the cost-effectiveness of hENT1 testing

The genus Manota Williston (Diptera, Mycetophilidae) in Japan, with a key to the Palaearctic species of the genus

The Japanese fauna of Manota comprises of 11 out of 14 Palaearctic species with a strong influence of Oriental elements in the southern subtropical parts of the country. The following five new species are described: M. curvistylus, M. kyushuensis, M. omotoensis, M. tripectinata, and M. yaeyamaensis. Three species are recorded for first time from Japan: M. bilobata Papp, 2004, M. epigrata Hippa, 20

Headgroup Effects on the Unusual Lamellar-Lamellar Coexistence and Vesicle-to-Micelle Transition of Salt-Free Catanionic Amphiphiles

Salt-free ion-paired catanionic amphiphiles of the C-m(+) C-n(-) type, with a high solubility mismatch (n >> m or m >> n) display a remarkable phase behavior in water. A temperature-driven vesicle-to-micelle transition in the dilute side together with a coexistence of two lamellar phases oil the concentrated side is one of the peculiar effects that have been reported for the hexadecyltrimethylammo

Fördjupad analys av Skånes Flora – 2. Indikatorvärden

In this second article in a series based on various analyses of data from the survey of the vascular flora of the province of Skåne, southern-most Sweden, completed 1987–2007, the geographic distribution of mean indicator values are mapped and discussed. The Ellenberg indicator values are applied and found to correlate well with actual conditions as far as light, temperature and soil reaction (pH)

Regulation of SERCA2 activity by PDE3A in human myocardium: Phosphorylation-dependent interaction of PDE3A1 with SERCA2.

PDE3 regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for these inotropic effects, and that murine PDE3A1 associates with SERCA2, PLB and AKAP18 in a multi-protein signalosome in human SR. Immunohistochemical staining demonstrated that PDE3A co-localiz

Tactoid Formation in Montmorillonite

Aqueous dispersions of Ca montmorillonite contain small clusters of clay platelets, often named "tactoids". In these tactoids, the platelets are arranged parallel to each other with a constant spacing of 1 nm. We have used small-angle X-ray scattering (SAXS) to determine the average number of platelets per tactoid, < N >. We found that this number depends on the platelet size, with larger platelet

A Digitally Assisted Non-Linearity Mitigation System for Tunable Channel Select Filters

This brief presents a low-complexity system for digitally assisting a channel select filter (CSF) to mitigate both even- and odd-order nonlinearities. The proposed solution is scalable and can be utilized for nonlinearity mitigation in different analog transceiver blocks. The system consists of an auxiliary path with a low-resolution analog to digital converter (ADC) enabling digital recreation an