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Activated protein C resistance (FVLeiden) and thrombosis: factor V mutations causing hypercoagulable states

The integrity of the vascular system is of prime importance for survival. Therefore, several emergency and repair systems safeguard the circulatory system. Multiple processes jointly limit vascular damage and blood loss. In this article, the authors focus on the protein C anticoagulant pathway and the role of activated protein C resistance in thrombotic disease, and they discuss the involvement in

Immuno-SLM—a combined sample handling and analytical technique

Immuno-supported liquid membrane (immuno-SLM) extraction is a new technique that makes use of antibody (Ab)–antigen interactions as the "extraction force" to drive the mass transfer in a selective way. In immuno-SLM, anti-analyte (Ag) Abs are introduced into the acceptor phase of the SLM unit to trap the Ag that passes from the flowing donor through the SLM into the stagnant acceptor. The amount o

Chronic illness among children in a total population. An epidemiological study in a Swedish primary health care district

The prevalence of chronic illness of all 6,080 0-15-year-old children in a defined geographical area in southern Sweden was studied. Information on the health status of the children was obtained from health and medical records, interviews with the district and school nurses and questionnaires to the parents. Chronic illness was defined as a disability interfering with normal life and/or demanding

Development and Application of Rotational Coherent Anti-Stokes Raman Spectroscopy and Laser-induced Fluorescence for Combustion Diagnostics

The thesis concerns the development and application of two laser-based methods for combustion diagnostics: dual broadband rotational coherent anti-Stokes Raman spectroscopy (CARS) and laser-induced fluorescence (LIF). In efforts to increase the usefulness of the CARS technique, the applicability of a method involving a combination of the rotational CARS technique and the closely related vibration

Intrauterine lung infection with Chlamydia trachomatis in a premature infant

The present study shows the probable intrauterine infection with Chlamydia trachomatis in a premature infant born in the 29th week of gestation. Chlamydiae were isolated from lung tissue collected at sterile autopsy and also demonstrated in sections of such tissue by immunofluorescence tests using monoclonal antibodies.

Significant impact of 5 alpha-reductase type 2 polymorphisms on sperm concentration and motility

Androgens, including 5 alpha-dihydrotestosterone (DHT), are known to play a role for spermatogenesis and accessory sex gland function. The enzyme 5 alpha-reductase (SRD5A) catalyses the conversion of testosterone to DHT. Our objective was to investigate whether polymorphisms in the SRD5A2 gene influence semen parameters in the general population. DNA from 182 Swedish military conscripts was examin

The impact of genetic, environmental and life-style factors on male reproductive function

Recent studies have indicated a decline in sperm number in the western world during the past 50 years, sperm concentration changing from 113 to 66 millions per mL. Furthermore, significant geographical differences in male reproductive function have been observed. In Finland, the sperm concentration was found to be substantially higher than in Denmark. In parallel, the incidence of testicular cance

Combining Keystroke Logging with Eye Tracking

This chapter describes the successful development of a new methodology for studying on-line writing. The text-logging tool ScriptLog has been combined with the eyetracking technology iView X HED HT, in order to enhance the study of the interplay between writing, monitoring and revision. Data on the distribution of visual attention during writing help determining to what extent pauses are used for

Von Willebrand's disease caused by compound heterozygosity for a substitution mutation (T1156M) in the D3 domain of the von Willebrand factor and a stop mutation (Q2470X).

Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involved in the intracellular multimerization of pro-VWF dimers. A VWD patient withseve

Wrist-bridging versus non-bridging external fixation for displaced distal radius fractures: a randomized assessor-blind clinical trial of 38 patients followed for 1 year

BACKGROUND: Non-bridging external fixation has been introduced to achieve better fracture fixation and functional outcomes in distal radius fractures, but has not been specifically evaluated in a randomized study in the elderly. The purpose of this trial was to compare wrist-bridging and non-bridging external fixation for displaced distal radius fractures. METHOD: The inclusion criteria were women

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Anaesthesia with closed anaesthetic systems demands knowledge of the physiology of the patients and of how the various anaesthetic gases behave in the organism as only the gases which the patients produces and absorbs are eliminated and replaced. The system is educational as it provides knowledge of the genuine absorption of oxygen and anaesthetic gases. The method is favourable to the environment

Restless legs - vanligt sjukdomstillstånd som ofta missas. Möjligheter till framgångsrik behandling finns idag

Restless legs syndrome (RLS) is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs. The symptoms appear when the limbs are at rest and are worst in the evening and at night. They force the patients to keep moving their legs, and sometimes to get out of bed and wander about. Periodic limb movements of the extremities (PLM) are common during sleep thu

Hankel operators and atomic decompositions in vector-valued Bergman spaces

Abstract This thesis consists of the following three papers Paper I. Hankel operators on Bergman spaces and similarity to contractions. In this paper we consider Foguel-Hankel operators on vector-valued Bergman spaces. Such operators defined on Hardy spaces play a central role in the famous example by Pisier of a polynomially bounded operator which is not similar to a contraction. On Bergman sp