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To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study.

Gel dosimetry measures the absorbed radiation dose with high spatial resolution in 3D. However, recently published data show that the response of metacrylic-based polymer gels depends on the segmented delivery pattern, which could potentially be a considerable disadvantage for measurements of modern dynamic radiotherapy techniques. The aim of this study is to design a dynamic compartment model for

The present study aimed to investigate how the impact of several factors linked to geography would shape life-history traits in a gregarious species, using the pine processionary moth (PPM) Thaumetopoea pityocampa as a model system. PPM has a wide geographical distribution over the Mediterranean Basin, and it is a strictly gregarious species throughout larval development, where the total reproduct

AIMS/HYPOTHESIS: The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS: Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (when smoking data were first registered) or later and

This article critically studies documentaries focusing on the "Islamic terrorist threat", produced in the US and in Western Europe. The particular films relate to the discourses of the growing far right political movements in liberal democracies. The article analyzes the communicational tactics deployed by the filmmakers for counter-terrorist mobilization of "Westerners". The films' producers obje

Breast cancer type 1 susceptibility protein (BRCA1) has a multitude of functions that contribute to genome integrity and tumor suppression. Its participation in the repair of DNA double-strand breaks (DSBs) during homologous recombination (HR) is well recognized, whereas its involvement in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial. Here we have st

This article builds on the life-stories of elderly Palestinian refugees, collected in the West Bank in 2003-2004. It discusses accounts about flight in 1948 (i.e. al-Nakba) and pays particular interest to stories as well as silences about dying children. The article argues that men and women remembered their flight differently and that the gendered experiences of flight influenced understandings o

We report on improved image detectability for fluorescence diffuse optical tomography using upconverting nanoparticles doped with rare-earth elements. Core-shell NaYF4 : Yb3+/Er3+ @ NaYF4 upconverting nanoparticles were synthesized through a stoichiometric method. The Yb3+/Er3+ sensitizer-activator pair yielded two anti-Stokes shifted fluorescence emission bands at 540 nm and 660 nm, here used to

First measurements of the W -> lv and Z/gamma* -> ll (l = e; mu) production cross sections in proton-proton collisions at root s = 7 TeV are presented using data recorded by the ATLAS experiment at the LHC. The results are based on 2250 W -> lv and 179 Z/gamma* -> ll candidate events selected from a data set corresponding to an integrated luminosity of approximately 320 nb(-1). The measured total

Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 interventio

Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect α-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We st

We study the induced subgraph isomorphism problem and the general subgraph isomorphism problem for small pattern graphs. We present a new general method for detecting induced subgraphs of a host graph isomorphic to a fixed pattern graph by reduction to polynomial testing for non-identity with zero over a field of finite characteristic. It yields new upper time bounds for several pattern graphs on

The Matern covariance function is a popular choice for modeling dependence in spatial environmental data. Standard Matern covariance models are, however, often computationally infeasible for large data sets. Recent results for Markov approximations of Gaussian Matern fields based on Hilbert space approximations are extended using wavelet basis functions. Using a simulation-based study, these Marko

Propionic acid was produced from glycerol using Propionibacterium acidipropionici. In this study, the impact of the concentrations of carbon and nitrogen sources, and of different modes of high cell density fermentations on process kinetics and -efficiency was investigated. Three-way ANOVA analysis and batch cultivations at varying C/N ratios at pH 6.5 revealed that propionic acid production rate

AIM: To investigate serial serum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in patients treated with mild hypothermia after cardiac arrest, and to study their association to severe infections, post cardiac arrest syndrome (PCAS) and long-term outcome. METHODS: Serum samples from cardiac arrest patients treated with mild hypothermia were collected serially at admission, 2, 6

Objective: This study evaluated the quality and readability of English-language internet information for adults with hearing impairment and their significant others. Design: Two keyword pairs (hearing loss and hearing aids) were entered into five country-specific versions of the most commonly used internet search engine in May 2011. Sample: For each of the 10 searches, the first 10 relevant websit

Abstract in UndeterminedSpatial data clearinghouses are one of the key features of a spatial data infrastructure (SDI). However, recent research indicates that few national clearinghouses function well, as the spatial data resources available cannot be satisfactorily accessed or optimally used. To improve the functionality, we propose that clearinghouses to be complemented with expert systems and

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the rat