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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and

Natur, spel, landskap

Genom jämförelser mellan beskrivningar och bilder av landskap hos Plinius d.y., Claude Lorrain, Super Mario World och Zelda Skyward Sword undersöker jag hur en serie konventioner rörande blick, avbildande och berättande tillsammans skapar en förståelse av naturen kring oss och ut ur denna producerar ett begripligt landskap.

Heterogeneous Effects of Birth Spacing on Neonatal Mortality Risks in Bangladesh

The negative relationship between birth interval length and neonatal mortality risks is well documented, but heterogeneity in this relationship has been largely ignored. Using the Bangladesh Maternal Mortality and Health Care Survey 2010, this study investigates how the effect of birth interval length on neonatal mortality risks varies by maternal age at birth and maternal education. There is sign

Anthropogenic and climatic impacts on a coastal environment in the Baltic Sea over the last 1000 years

Coastal environments have experienced large ecological changes as a result of human activities over the last 100–200 years. To understand the severity and potential consequences of such changes, paleoenvironmental records provide important contextual information. The Baltic Sea coastal zone is naturally a vulnerable system and subject to significant human-induced impacts. To put the recent environ

A new fossil evaniid wasp from Eocene Baltic amber, with highly modified compound eyes unique within the Hymenoptera

Evaniid wasps develop as solitary egg predators within the oothecae of cockroaches. Fossil evaniids are relatively common compared with most other parasitoid Hymenoptera, undoubtedly due to their searching for host cockroaches on tree trunks and thus an increased chance of being trapped in tree resin. The genus Parevania Kieffer, 1907 is widely distributed through the Old World and is also known f

Dipolar particles in a double-trap confinement : Response to tilting the dipolar orientation

We analyze the microscopic few-body properties of dipolar particles confined in two parallel quasi-one-dimensional harmonic traps. In particular, we show that an adiabatic rotation of the dipole orientation about the trap axes can drive an initially nonlocalized few-fermion state into a localized state with strong intertrap pairing. With an instant, nonadiabatic rotation, however, localization is

Multi-GEM detectors in high particle fluxes

Gaseous Electron Multipliers (GEM) are well known for stable operation at high particle fluxes. We present a study of the intrinsic limits of GEM detectors when exposed to veiy high particle fluxes of the order of MHz/mm2. We give an interpretation to the variations of the effective gain, which, as a function of the particle flux, first increases and then decreases. Wre also discuss the reduction

Biological conversion of aromatic monolignol compounds by a Pseudomonas isolate from sediments of the Baltic Sea

Bacterial strains were isolated from the sediments of the Baltic Sea using ferulic acid, guaiacol or a lignin-rich softwood waste stream as substrate. In total nine isolates were obtained, five on ferulic acid, two on guaiacol and two on a lignin-rich softwood stream as a carbon source. Three of the isolates were found to be Pseudomonas sp. based on 16S rRNA sequencing. Among them, isolate 9.1, wh

2D and 3D Nanoscale Imaging Using High Repetition Rate Laboratory-Based Soft X-Ray Sources

In this contribution, we report about tomographic nanoscale imaging using a laser-produced plasma-based laboratory transmission X-ray microscope (LTXM) in the water window. The soft X-ray radiation of the LTXM is provided by a high average power laser-produced (1.3 kHz repetition rate, 0.5 ns pulse duration, 140 W average power) plasma source, a multilayer condenser mirror, an objective zone plate

Assessment of Competence in EVAR Procedures : A Novel Rating Scale Developed by the Delphi Technique

OBJECTIVE/BACKGROUND: To develop a procedure specific global rating scale for assessment of operator competence in endovascular aortic repair (EVAR).METHODS: A Delphi approach was used to achieve expert consensus. A panel of 32 international experts (median 300 EVAR procedures, range 200-3000) from vascular surgery (n = 21) and radiology (n = 11) was established. The first Delphi round was based o

On Giddens: Interpreting Public Relations through Anthony Giddens’s Structuration and Late Modernity Theories

Public relations was historically an isolated theoretical field and an, in practice, undeveloped organizational publicity function for many years. From the perspective of strategy research, theory as well as practice has traditionally been dominated by traditional, rational, linear and functionalistic approaches (Whittington, 2000). The foundation in functionalism has led researchers to focus on e

Researchers’ online visibility : Tensions of visibility, trust and reputation

Purpose – The purpose of this article is to understand what role researchers assign to online representations on the new digital communication sites that have emerged, such as Academia, ResearchGate or Mendeley. How are researchers’ online presentations created, managed, accessed and, more generally, viewed by academic researchers themselves? And how are expectations of the academic reward system

Mapping the plastics system and its sustainability challenges

Plastics are versatile materials with environmental, technical, economical and societal benefits, however plastics also contribute negatively to the environment and climate. Put in numbers around 4% of the fossil oil and gas is used as feedstock for plastics while another 4% is used for providing energy for the manufacturing of plastics. Many initiatives on reducing the negative effects of plastic

Experimental investigations and correlation development of convective heat transfer in a rotating smooth channel

An experimental study has been carried out to investigate the effects of Coriolis force and centrifugal buoyancy force on convective heat transfer in a smooth cooling channel under rotating condition in a new rotation facility. The main motivation behind this work is to obtain required data for developing heat transfer correlations based on rotating state. In accordance with the open literature, f