The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Recruitment of these signal t

1.INTRODUCTIONBefore the phase-out of incandescent lamps in the EU, interior lighting was responsible for approximately 20% of average household electricity use in Sweden. To save energy and reduce greenhouse gas emissions, a major societal goal is to switch from light sources with low lm/W to ones with higher luminous efficacy and to reduce wasteful energy behaviour, while still meeting end user

1. Motivation, specific objectiveTo evaluate the first prototype of a home lighting system, we used a full-scale model of a studio apartment in the laboratory of the School of Architecture at Lund University. The personalised home lighting system is based on LEDs, wearable sensors and a mobile phone app to produce lighting tailored to the individual’s needs. Drawing on participant interviews (n =

Introduction: Preoperative smoking intervention programmes reduce post‐operative complications in smokers. Little is known about the long‐term effect upon smoking cessation. Aim: To discover long‐term quit rates and the reasons behind successful cessation. Materials and Methods: 101 one of 120 smokers, randomised to smoking intervention or no intervention before hip and knee surgery, completed que

While the contemporary academic discourse regards innovation as an inherent feature of infrastructure public‒private partnerships (PPPs), the conceptual link between infrastructure PPPs and innovation is narrowly understood. While most existing studies conceptualize the innovation processes and effects within the context of PPP projects, we argue that the relevance of innovation in infrastructure

An experimental setup for microwave stimulation of a turbulent flame is presented. A low-swirl flame is being exposed to continuous microwave irradiation inside an aluminum cavity. The cavity is designed with inlets for laser beams and a viewport for optical access. The aluminum cavity is operated as a resonator where the microwave mode pattern is matched to the position of the flame. Two metal me

The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe

In transportation planning, solutions designed to meet objectives of equity and social inclusion have to be achieved. From this standpoint, most of Network Design Problem (NDP) models aim at identifying the optimal layout of transportation networks by deterministic bi-level problems formulation to reflect the different goals of at least two decision makers (the network users and the planner). Cons

Knowledge development and paradigm shift for peptic ulcer disease is described over a fifty-year period using four levels of knowledge that place demands on the healthcare organization. When medical knowledge reached a healing level, continuity became subordinate. However, accessibility to treatment became more important. An important task for future healthcare will be to define and create broader

For the purpose of functionalizing III-V semiconductor nanowires using n-doping, Sn-doped GaAs zincblende nanowires are produced, using the growth method of Aerotaxy. The growth conditions used are such that Ga droplets, formed on the nanowire surface, increase in number and concentrations when the Sn-precursor concentration is increased. Droplet-covered wires grown with varying Sn concentrations