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The direct reprogramming of adult skin fibroblasts to neurons is thought to be controlled by a small set of interacting gene regulators. Here, we investigate how the interaction dynamics between these regulating factors coordinate cellular decision making in direct neuronal reprogramming. We put forward a quantitative model of the governing gene regulatory system, supported by measurements of mRNA
Digitalisation is rapidly changing the availability of information and services online. This is accompanied by cutbacks to physical services in an attempt to save costs and increase efficiency. Digital skills have thus become critical to accessing and benefiting from developments in the digital age. This may have implications for social inclusion in geographically peripheral and sparsely populated
This paper examines how Palestinian men and women are affected by poverty related to violent conflict. By acknowledging socio-cultural understandings of gender relations, it shows how men and women become vulnerable in different ways. To counter poverty, both women and men are dependent on viable social networks. It is however clear, that females, especially those in female-headed households, have
This vital new collection presents new Marxist-Feminist analyses of Capitalism as a gendered, racialized social formation that shapes and is shaped by specific nature-labour relationships. Leaving behind former overtly structuralist thinking, Marxist-Feminist Theories and Struggles Today interweaves strands of ecofeminism and intersectional analyses to develop an understanding of the relations of
This study concerns UN Security Council’s Resolution 1325 and its relevance in the OPT. By reviewing statistics and reports as well as acknowledging socio-cultural understandings of gender relations, it shows how men and women become affected by violence in different ways. In general, women are affected more indirectly than men by violence committed by the Israeli Defence Forces. However, the viol
This article focuses on the ways in which women employed in Vietnam’s heavy industry, mitigate and cope with crises at the workplace and in social life. Drawing on ethnographic fieldwork, which I have conducted in the Industrial Zones of northern Vietnam in the international corporations called Xylan and Yate, I examine how women who are working on the floor manage crises entanglements as an under
In a crisis-ridden world, it has become increasingly pertinent to understand the breadth and depth of ‘crisis’. On a daily basis, we are alarmed by crisis reports concerning hurricanes and floods; economic and financial uncertainties; political instability; armed conflict; desperate refugees and migrants; persisting poverty; and outbreaks of aggressive global diseases such as Covid-19. This specia
ALS is characterized by the degeneration of upper and lower motor neurons. In about 70% of patients with ALS the disease has an spinal onset, while about 30% of the patients have a bulbar onset. Cognitive dysfunction and behavioral changes are seen in about 50% of the patients, and 15% develop frontotemporal dementia. There is no single test that provides the ALS diagnosis. The diagnosis is based
Huntington's disease is an autosomal dominant neurodegenerative disease that leads to premature death. The disease is caused by a pathological CAG triplet expansion in the huntingtin gene. The disease is most common in Western populations, with onset in middle age and causing progressive motor, cognitive, and psychiatric symptoms. Currently, only symptomatic treatment is provided, but new molecula
This chapter examines mobilisation around sexuality and gender identity in Southeast Asia through an examination of how the lesbian, gay, bisexual, and transgender (LGBT) movement in Vietnam has pursued full recognition and equal rights for all, regardless of sexuality and gender. As the chapter details, the Vietnamese LGBT movement is composed of informal activist groups and networks as well as f
This article reports a Swedish research project designed to study the impact of a cyclic light system, sound absorbents, and selected interior design changes in rooms within an intensive care unit. The authors describe the limitations of many previously reported intensive care unit (ICU) design research projects, and believe that much more knowledge is needed, which reflects a multidisciplinary pe
Antalet asylsökande som undantas från flyktingkonventionens skydd ökar ständigt i Sverige. Leyla Belle Drake och Amin Parsa tar sig an fallet med den 69-årige afghanske mannen som nekats asyl på grund av misstankar om folkrättsbrott i Afghanistan under 80-talet, och finner en skärningspunkt mellan flyktingrätten och straffrätten. Är det i själva verket inkluderingen av de andra i en mänsklighet so
