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Intergenerational Care in Corona times. : A Study of Relationships, Commitments, and Practices of Care in Swedish Families during a Pandemic

The corona pandemic has put intergenerational relationships in focus in ways previously never experiences. In many national contexts, lockdowns and restrictions have caused forced generational separation in families. In Sweden, the official government standpoint of generational separation – all citizens over 70 were to avoid contact with others, and especially to stay away from interactions with g

Ambiguous vitality: Gardening between desired heritage and despised invasiveness

Gardeners have always used plants of different origins, moving them around to new environments, working hard to make the plants survive and thrive under new conditions. In gardens, vitality is often regarded as an asset and a reason to cultivate certain plants. Many varieties that have spread over centuries are today regarded as ‘belonging’, as more or less ‘natural’, and even as heritage plants. Gardeners have always used plants of different origins, moving them around to new environments, working hard to make the plants survive and thrive under new conditions. In gardens, vitality is often regarded as an asset and a reason to cultivate certain plants. Many varieties that have spread over centuries are today regarded as ‘belonging’, as more or less ‘natural’, and even as heritage plants.

CYP2D6 genotype predicts tamoxifen discontinuation and drug response : a secondary analysis of the KARISMA trial

Background: Guidelines regarding whether tamoxifen should be prescribed based on women's cytochrome P450 2D6 (CYP2D6) genotypes are conflicting and have caused confusion. This study aims to investigate if CYP2D6 metabolizer status isa associated with tamoxifen-related endocrine symptoms, tamoxifen discontinuation, and mammographic density change. Patients and methods: We used data from 1440 health

Wear mechanisms of PcBN tools when machining AISI 316L

This paper investigates the machinability of AISI 316L stainless steel without and with NMI treatment, when machined with three different PcBN tool grades: low cBN content (50% vol.), medium (65% vol.) and high (90% vol.). The NMI treatment consisted of resulfurized and Ca-treated steels with two different Si/Al ratio. The tool materials were evaluated in terms of tool life, showing the best perfo

Optically stimulated luminescence dating supports pre-Eemian age for glacial ice on the Lomonosov Ridge off the East Siberian continental shelf

Establishing a solid chronological framework for Arctic marine sediments is a critical first step towards glacial and palaeoceanographic reconstructions. However, this has historically been more challenging than elsewhere in the world, and often results in core chronologies and subsequent paleoenvironmental reconstructions being questioned and overturned. Optically stimulated luminescence (OSL) da

Kan man lita på en trust?

I boken klargörs den anglosaxiska trusten struktur, funktion och rättsverkningar. I boken utreds om det finns behov av en svensk trust.

Investigation on the elimination of geyser in a cryogenic pipe by a recirculation method

A geyser elimination approach using recirculation methods is investigated in the present work, which is essential to guarantee the integrity of facilities. Both experimental and numerical methods are adopted in the investigation using LN2 as working fluids. A recirculation pipe is designed to eliminate geysers in a cryogenic vertical pipe. The performance of the recirculation method is comprehensi

Combining crystallography with quantum mechanics

In standard crystallographic refinement of biomacromolecules, the crystallographic raw data are supplemented by empirical restraints that ensure that the structure makes chemical sense. These restraints are typically accurate for amino acids and nucleic acids, but less so for cofactors, substrates, inhibitors, ligands and metal sites. In quantum refinement, this potential is replaced by more accur

Policy challenges to community energy in the EU : A systematic review of the scientific literature

In response to the ongoing climate crisis, many countries have issued policies to support the uptake of renewable energy. In the same vein, the European Union (EU) has issued a revised renewable energy directive in 2018. One of the pillars of the directive is the support for community energy initiatives, i.e. sustainable energy initiatives run by or with the participation of citizens. The concept

Shear-induced nanostructural changes in micelles formed by sugar-based surfactants with varied anomeric configuration

Hypothesis: The self-assembly of long tail sugar-based surfactants into worm-like micelles has recently been demonstrated, and the rheological properties of such systems have been shown to be tuneable through subtle modifications of the molecular characteristics of the surfactant monomer. In particular, the anomeric configuration of the hexadecylmaltoside headgroup was shown to induce profound cha

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patients exhibiting more aggressive forms of vascular disease and poorer outcomes after surgery. Kv1.3 channels are critical players in VSMC proliferation.

Target Localization and Circumnavigation with Integral Action in R2

Prior results on target localization and circumnavigation with bearing measurements in $\mathbb {R}^{2}$ are extended with integral action, resulting in a control system that is robust to bounded load disturbances on the control inputs. Such disturbances may arise in practice due to modeling errors and need to be considered to ensure small tracking errors. The control inputs are modeled as the sys

Brottslingar av en mycket speciell sort. : Spionskandalen som en maktkamp mellan visselblåsare, grävande journalister och underrättelsetjänster.

Spy scandals in Western democracies can be seen as a power battle between three actors: investigative journalists, whistleblowers and the intelligence organizations at the center of the scandal. It is a conflict played out both within and outside of the court-house as the actors try to claim the label “hero” for themselves while actively trying to repudiate other labels, such as “traitor”, “spy” o

Acceptability of a digital return-to-work intervention for common mental disorders : a qualitative study on service user perspectives

Background: There is an evident discrepancy between need and provision of evidence-based return-to-work (RTW) interventions in existing mental health services. Online dissemination of evidence-based interventions is presumed to reduce this gap. However, there is almost no knowledge available on perceived acceptability of digital RTW interventions among service users, which are factors that might i

A review of HVAC solution-sets and energy performace of nearly zero-energy multi-story apartment buildings in Nordic climates by statistical analysis of environmental performance certificates and literature review

Multi-story apartment buildings, also known as multi-family or multi-unit residential buildings, represent the largest share of newly constructed, residential floor area in Norway, Sweden and Finland. Since the start of 2021, these buildings are required to be nearly-zero-energy under the Energy Performance of Buildings Directive. However, there has been limited research into defining solution-set

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity

The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs in mouse and human, is highly and specifically expressed in late terminal erythroid differentiation (TED). In this study, we investigated the role of Ypel4 in murine erythropoiesis, providing for the f