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Background: Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More recently, an oxidized form of 5-mC, 5-hydroxymethylcytosine (5-hmC) has gained lot of attention as a regulatory epigenetic modification with prognostic and diagnostic implications for several cancers. However, there is no global study
The inclusive top-quark pair (tt¯) production cross-section σtt¯ is measured in proton–proton collisions at a centre-of-mass energy s = 5.02 TeV, using 257 pb−1 of data collected in 2017 by the ATLAS experiment at the LHC. The tt¯ cross-section is measured in both the dilepton and single-lepton final states of the tt¯ system and then combined. The combination of the two measurements yields σtt¯=67
Gaia Data Release 3 provides novel flux-calibrated low-resolution spectrophotometry for '220 million sources in the wavelength range 330 nm ≤ λ ≤ 1050 nm (XP spectra). Synthetic photometry directly tied to a flux in physical units can be obtained from these spectra for any passband fully enclosed in this wavelength range. We describe how synthetic photometry can be obtained from XP spectra, illust
Dimensionality reduction is an Exploratory Data Analysis (EDA) approach allowing for fast visualization of high-dimensional data and the possibility of discovering hidden systematic patterns within a data set. While linear dimensionality reduction techniques, such as Principal Component Analysis (PCA), are considered the golden standard in many areas of data science, they seem to be inadequate for
This work is focused on the modelling of experimental behaviour of a bone-shape sample made of aluminium alloy AW5083 under tension. This behaviour involves propagating instabilities, namely Lueders bands and the Portevin–Le Chatelier effect. A series of experiments was performed at room temperature for three loading rates, showing the instabilities and failure. In the paper a large strain thermov
Friction characteristics and wear of sheet-bulk metal forming tools featuring microstructured surfaces are simulated on the mesoscale. Computational homogenisation is used for surface cut-outs on which the structures are geometrically resolved and where friction laws model lower scale roughness. Two approaches are presented for the modelling of wear. A dissipation based Archard model is implemente
Background and objective Low-density computed tomography (LDCT) improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data. Hence, accurate diagnosis of early-stage lung cancer remains challenging. The purpose of the study was to assess the feasibility of using circulating tumour cells (CTCs) to differentiate malignant from benign pulmonary nodules. Mate
This study explores the potential benefits of combining a wave-shaped piston geometry with post injection strategy in diesel engines. The wave piston design features evenly spaced protrusions around the piston bowl, which improve fuel-air mixing and combustion efficiency. The ‘waves’ direct the flames towards the bowl center, recirculating them and utilizing the momentum in the flame jets for more
Circular economy (CE) has been of utmost interest in the industry and research community in the preceding years. However, CE is still a nascent research field in the built environment context. As technological advances within CE are slowing, the incorporation of business models into the concept is deemed important to achieve the necessary transition. Circular business models within the built envir
En analys av intervjuer som genomförts på Statens institutionsstyrelse LVM-hem i samband med att en person tvångsomhändertagits jmf LVM. Analysen är ett vetenskapligt underlag till SOU 2023:5 Från delar till helhet. Tvångsvården som en del av en sammanhållen och personcentrerad vårdkedja.
Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological life. There are three isozymes of nitrogenase, differing in the composition of the active site, viz., Mo, V, and Fe-nitrogenase. Recently, the first crystal structure of Fe-nitrogenase was presented. We have performed the first combined quantum mechanical and molecular mechanical (
En systematisk genomgång av internationella vetenskapliga studier inom tvångsvård av personer med beroende.
This article analyses the competence shift in EU competition law, with a particular focus on the digital era and the EU’s institutional dimension. As will be argued, the latter is expanding by means of new legislation in the Digital Single Market. Particularly Article 114 TFEU is employed as a legal base for this purpose, which essentially harmonises and pre-empts Member States’ action in this are
While the role of grandparents has increasingly been explored, the position of being a grandchild is under-researched. Recognising the active role of children in intergenerational care relationships, we analyse narratives of being a grandchild in Sweden in the 1940s–1950s, the 1970s–1980s, and today. Interviews with 63 participants of both genders show how conditions for care-doings change in resp
En studie av hur föreställningsförmågan, det inre seendet, uppmuntrades av några Vadstena-predikanter på 1400-talet. Framför allt tar artikeln upp en predikan över den Apostoliska trosbekännelsen, vilken kopplas samman med ädelstenarna i den Heliga Stadens grundmurar i Uppenbarelseboken. Artikelförfattaren gör en koppling till ett unikt smycke, det s k Motalaspännet.
Research on gender-fair language aims to identify language inclusive to a multitude of individuals, for example, increasing the visibility of women by using paired pronouns (he/she) instead of generic masculine forms (he). However, binary presentations like he/she might come with unwanted side effects and evoke what we label as normative gender bias. A normative gender bias is defined as when word
Presented are the first measurements of the transverse single-spin asymmetries (AN) for neutral pions and eta mesons in p+Au and p+Al collisions at sNN=200 GeV in the pseudorapidity range |η|
In ultraperipheral collisions (UPCs) of relativistic nuclei without overlap of nuclear densities, the two nuclei are excited by the Lorentz-contracted Coulomb fields of their collision partners. In these UPCs, the typical nuclear excitation energy is below a few tens of MeV, and a small number of nucleons are emitted in electromagnetic dissociation (EMD) of primary nuclei, in contrast to complete
