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Both in the humanities and in the sciences, researchers make mistakes, and this is an essential part of the creative process. In a wider historical perspective, dead-ends can turn out to be the way forward. Two fathers of scientific systems, Aristotle and Carl Linnaeus, serve as an argument for the thesis that errors, or what we later label as such, are a necessary element of scientific work. In
I kapitlet resoneras utifrån ett rättssociologiskt perspektiv, kring vilka möjligheter barnkonventionen som lag har att förändra yrkesverksammas arbete i praktiken, med poliser som exempel. Poliser kan, liksom flera andra offentligt anställda tjänstepersoner, ses som ”gräsrotsbyråkrater” vars handlingsutrymme påverkas och styrs av en mängd andra faktorer förutom lagstiftning. I kapitlet diskuteras
I denna antologi fokuseras och diskuteras barnkonventionen som rättligt och praktiskt verktyg utifrån olika forskningsområden och praktiska verksamheter. Bokens författare är forskare tillhörande olika vetenskapliga discipliner, varmed barnkonventionens praktiska innebörd relateras till forskning inom ämnena: offentlig rätt, civilrätt, socialt arbete, rättssociologi, folkhälsovetenskap, socialmedi
This article describes field monitoring and supplementary simulations of an existing daylighting and electric lighting integrated design for a furniture store. First in its type, the store includes several areas of the showroom provided with abundant daylighting. For the monitoring, the areas of the living rooms and the home decoration exhibitions were selected. They include wide glazed areas, day
The recently launched IEA SHC Task 61 aims at fostering the integration of daylighting and electric lighting solutions for the benefit of higher user satisfaction and energy savings at the same time. In order to drastically reduce the energy use of buildings daylighting, electric lighting and associated controls must be integrated, and the role of the user should be considered in the integration p
This article evaluates students’ expectations and feelings of a short bi-directional International Credit Mobility (ICM) teaching exchange between Lund University, Sweden and the Royal University of Bhutan. The teaching exchange regarded two courses on fundamentals of energy production from PV and fundamentals of daylighting. The evaluation was carried out via focus groups. The results suggest tha
PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.METHODS: We id
In this Article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS product to the open-source platform. The paper initially describes the technical details of the new software development platform. This is followe
Creating efficient public transport systems that attract users is a challenging task in contexts where the control of public transport is divided between various actors. Recent research on public transport has therefore seen increasing focus on issues like coordination, collaboration and steering in complex governance settings. However, more is known about what needs to be done than how to impleme
Objectives: We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate whether the treatment of this patient group is in accordance with the EPOS recommendations. Design, settings and participants: Adult patients with a diagnosis of CRSwNP, and a history of at least t
Objectives: A substantial proportion of individuals with stroke are of working age. After stroke, it is important to return to work (RTW), both for the individual's satisfaction with life and economically for society. The current comprehensive, long-term study aimed at investigating in what time period the RTW continues after stroke and what factors could predict RTW. Materials and methods: All in
Erlotinib (Tarceva) targets the epidermal growth factor receptor (EGFR), which is commonly overexpressed in human cancers, including lung cancer. We show that erlotinib can be labeled with [(11)C] by reacting the normethyl precursor with [(11)C]-methyl iodide. By using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide proliferation assay, two lung cancer cell lines (A549 and NCI358)
Bladder cancer tumors expressing human epidermal growth factor receptor 4 (HER4) demonstrate improved patient survival. HER4 isoforms and estrogen receptor alpha (ER-α) can form chaperone complexes causing cell-proliferation. We wanted to explore if HER4 isoforms and ER-α could correlate to poor prognosis in bladder cancers. We developed mRNA assays for HER4 isoforms (JM-a, JM-b, CYT1, and CYT2) a
BACKGROUND: The epidermal growth factor (EGF) receptors HER2 and HER4 and the ligands HB-EGF and NRG1 are crucial for heart development. The purpose of our study was to investigate the role of the complete EGF system in relation to hypoxia of the heart.METHODOLOGY/PRINCIPAL FINDINGS: We examined the mRNA expression by real time PCR of the 4 receptors and 12 ligands from the EGF-system in paired no
BACKGROUND: We have previously developed (11)C-erlotinib as a new positron emission tomography (PET) tracer and shown that it accumulates in epidermal growth factor receptor (EGFR)-positive lung cancer xenografts in mice. Here, we present a study in patients with non-small cell lung cancer (NSCLC) investigating the feasibility of (11)C-erlotinib PET as a potential method for the identification of
The level of extracellular calcium has been demonstrated to regulate important physiological processes like cell growth and apoptosis. We demonstrate that in the bladder cancer cell line RT4, an increased extracellular calcium level induces apoptosis and that the HER1 receptor functions as a cell survival factor and delays apoptosis. After 12 h of calcium treatment (10 mM) apoptosis was detected i
The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. It has been speculated that the RAI product induces apoptosis by blocking NF-kappaB or inhibits apoptosis by blocking p53. Either way the gene could influence the survival of precancerous lesions. Here we re
OBJECTIVE: To investigate the effect of the epidermal growth factor receptor (EGFR) on the induction of apoptosis by the chemotherapeutic agent etoposide (VP16), and to examine the effect of combining VP16 with gefitinib to see if the cell-survival mechanism can be prevented.MATERIALS AND METHODS: The bladder cancer cell lines RT4 and T24, representing low- and high-malignancy grades respectively,
Increased expression of the epidermal growth factor (EGF) receptors, HER1 and HER2 are related to poor prognosis in most cancers studied. Recently, a high expression of the two remaining receptors of the EGF system, HER3 and HER4 has been related to a favourable prognosis. However, prognostic significance of HER1 and HER2 receptors in bladder cancer is controversial and the effect of the expressio
PURPOSE: The goal of this study was to identify proteins down-regulated during bladder cancer progression.EXPERIMENTAL DESIGN: By using comparative proteome analysis and measurement of mRNA, we found a significant down-regulation of S100C, a member of the S100 family of proteins, in T24 (grade 3) as compared with RT4 (grade 1) bladder cancer cell lines. Moreover, quantification of the mRNA level r
